NeuroTimone Facility (PFNT)

The PFNT Facility is a coherent set of exploration tools in neurobiology allowing research at the molecular, cellular and integrated levels.

News

  1. Semaine du cerveau 2021 : Notre cerveau : des neurones… et quoi d’autre ?  

    La 22ème édition de la « Semaine du Cerveau » s’adapte à la pandémie ! Plusieurs chercheurs de l’INP (Caroline Strube, Olivier Bosler et Anne-Marie François-Bellan) membres de l’association « cerveau point comm » participent à l’organisation au niveau régional de la Semaine du Cerveau, une manifestation internationale grand public coordonnée en France par la Société des Neurosciences.

  2. L'équipe GlioME fière de la nomination de Chiara Bastiancich au Prix Départemental pour la recherche, section Jeune Chercheur

    Mardi 16 février 2021, Chiara Bastiancich, Post-doc dans l'équipe GlioME faisait partie des 3 nominés en lice pour le prix "Jeune Chercheur" au 5ème Prix Départemental de la recherche en Provence organisé par le Département des Bouches du Rhône.

  3. Dominic Bingham (NeuroCyto team) at Neurobinar #5

    On February 18 at 4 pm, come and discover the work of Pierre-Yves Jacob (LNC), Lucas Goirand-Lopez (INMED) and Dominic Bingham (INP, NeuroCyto team). Dominic Bingham and Lucas Goirand-Lopez will introduce their respective PhD in a cross-presentation. After a question session for PhD students, Pierre-Yves Jacob will share with us his research on the brain network underlying spatial navigation (displacement, orientation) in complex environments.

  4. De "nouvelles têtes" dans l'équipe GlioME !

    L'équipe GlioME a le plaisir d'accueillir actuellement 3 nouveaux étudiants (de gauche à droite sur la photo):

    - Victoria Hein, doctorante en 1ère année, qui débute sa thèse sur le thème "Cellules souches de glioblastome et gangliosides : vers de nouvelles approches thérapeutiques", co-encadrée par Emeline Tabouret et Dominique Figarella-Branger.

  5. Christophe Leterrier (NeuroCyto team) in Nature Materials

    Christophe Leterrier from the NeuroCyto team just published a study in collaboration with the Cytomorpho lab  - Manuel Théry & Laurent Blanchoin, CEA Paris/Grenoble. Entitled “Self-repair protects microtubules from destruction by molecular motors”, this work demonstrates how motor proteins kinesins and dynein can damage microtubule while walking on them, triggering repair by incorporation of new tubulin monomers inside the microtubule lattice. It was published on Jan.

  6. Dominika Pilat (Team 1) on the Neurobinar #4 (NeuroMarseille) !

    Dominika Pilat will be presenting on the Neurobinar #4 on January 21 at 4 pm on Zoom.

    For this fourth edition, NeuroMarseille is pleased to welcome Cédric Maurange (IBDM), Dominika Pilat (INP) and Borloz Émilie (MMG). Dominika Pilat and Borloz Émilie will introduce their respective theses in a cross presentation. After a question session, Cédric Maurange (IBDM) will explain his research on genetic programmes modifying the properties of neural stem cells during development.

  7. INP goes green !

    When you say New Year, you say new resolutions! 
    Increasingly present at the heart of debates and minds, ecology is part of our daily lives and it is our duty to do everything we can to reduce our ecological footprint. The INP has decided to be mobilized for ecology, at its own level. 

    To begin with, we have set up a plastic bottle collection system to recycle our bottles in a short circuit. This is done via the collection system proposed by the company Yoyo, which guarantees delivery to the nearest recycling plant for 100% recycling! We have three collection points on our premises (salle de convivialité R+3, R+1 et R+2 vert). 

  8. Christophe Leterrier (NeuroCyto team) in the Journal of Neuroscience: “A Pictorial History of the Neuronal Cytoskeleton”

    Christophe Leterrier, leader of the NeuroCyto team, just published a special review for the 40th anniversary issue of the Journal of Neuroscience. Entitled “A Pictorial History of the Neuronal Cytoskeleton”, it is a journey through the history of the neuronal cytoskeleton in pictures.

Pages

INP in numbers

  • 126 members
  • 44 researchers
  • 48 research assistants
  • 12 post-docs
  • 11 PhD

 

Semaine du cerveau 2021 : Notre cerveau : des neurones… et quoi d’autre ?  

La 22ème édition de la « Semaine du Cerveau » s’adapte à la pandémie ! Plusieurs chercheurs de l’INP (Caroline Strube, Olivier Bosler et Anne-Marie François-Bellan) membres de l’association « cerveau point comm » participent à l’organisation au niveau régional de la Semaine du Cerveau, une manifestation internationale grand public coordonnée en France par la Société des Neurosciences.

Undefined

L'équipe GlioME fière de la nomination de Chiara Bastiancich au Prix Départemental pour la recherche, section Jeune Chercheur

Mardi 16 février 2021, Chiara Bastiancich, Post-doc dans l'équipe GlioME faisait partie des 3 nominés en lice pour le prix "Jeune Chercheur" au 5ème Prix Départemental de la recherche en Provence organisé par le Département des Bouches du Rhône.

Undefined

Dominic Bingham (NeuroCyto team) at Neurobinar #5

On February 18 at 4 pm, come and discover the work of Pierre-Yves Jacob (LNC), Lucas Goirand-Lopez (INMED) and Dominic Bingham (INP, NeuroCyto team). Dominic Bingham and Lucas Goirand-Lopez will introduce their respective PhD in a cross-presentation. After a question session for PhD students, Pierre-Yves Jacob will share with us his research on the brain network underlying spatial navigation (displacement, orientation) in complex environments.

Undefined

Dominika Pilat (Team 1) on the Neurobinar #4 (NeuroMarseille) !

Dominika Pilat will be presenting on the Neurobinar #4 on January 21 at 4 pm on Zoom.

For this fourth edition, NeuroMarseille is pleased to welcome Cédric Maurange (IBDM), Dominika Pilat (INP) and Borloz Émilie (MMG). Dominika Pilat and Borloz Émilie will introduce their respective theses in a cross presentation. After a question session, Cédric Maurange (IBDM) will explain his research on genetic programmes modifying the properties of neural stem cells during development.

Undefined

INP goes green !

When you say New Year, you say new resolutions! 
Increasingly present at the heart of debates and minds, ecology is part of our daily lives and it is our duty to do everything we can to reduce our ecological footprint. The INP has decided to be mobilized for ecology, at its own level. 

English

Next seminars

5 Mar 2021 14:30

INP external seminar : Jeffrey Lopez-Rojas (Columbia University)

Dr Jeffrey Lopez-Rojas will give a seminar entitled "Entorhinal Cortex input to the Hippocampus: hearing the news from a faraway place" friday 5th march at 14h30 via  Zoom 

Dr. Lopez-Rojas received his Bachelor's degree in Biochemistry from Havanna University. He received his Ph.D. in Neuroscience from the Otto von Guericke University in Germany, under Prof. Julietta U. Frey's supervision. During his Ph.D., he worked on the mechanisms of functional plasticity in the Entorhinal Cortex-Dentate Gyrus synapses. He found that activity-dependent changes in the Dentate Gyrus are largely related to modifications in neuronal excitability. Since 2019 he has been an Associate Research Scientist at Steve Sigelbaum's laboratory at Columbia University, where he studies the contribution of the Entorhinal input to CA2 in the ability of an animal to recognize and remember a conspecific. Overall, Dr. Lopez-Rojas's main research interest is on understanding how the functional dialogue between the Entorhinal Cortex, the Hippocampus and the Prefrontal Cortex supports the formation and storage of declarative memories.

12 Mar 2021 14:00

Audrey Jacq PhD defense

No seminar this afternoon since Audrey Jacq will defend her PhD (behind closed door)

19 Mar 2021 14:30

INP external seminar : André Steinecke (Max Planck Florida Institute)

Dr André Steinecke, Ph.D. Research Fellow Dr. Hiroki Taniguchi’s Laboratory – Development and Function of Inhibitory Neural Circuits, will give a seminar entitled "Neuromodulatory Control of Network Arborization in the Developing Neocortex.” friday 19th march at 14h30 via  Zoom

RESEARCH STATEMENT

My broad research interest is to study the development of inhibitory cortical circuits from migration and integration of interneurons to plasticity and function. During my current project, I discovered a mechanism by which acetylcholinergic neuromodulation shapes the integration of Cortical Chandelier cells through activation of voltage-gated calcium channels. My long-term goal is to understand principles of the self-organization of inhibitory neural circuits in health and disease.       

EDUCATION

  • 2013 – Present Research Fellow at Max Planck Florida Institute    Jupiter, FL

Dr. Hiroki Taniguchi’s Laboratory - Development and Function of Inhibitory Neural Circuit       
“Activity-Dependent development of Cortical Interneurons with a special focus on the Neuromodulatory Control of the postnatal Network Integration of Cortical Chandelier Cells.”

  • 2009-2013 PhD, Neuroscience      

Dissertation: “The role of the gene Disrupted-in-Schizophrenia-1 (DISC1) during the tangential migration of cortical interneurons in mice.”
Supervisor: Prof. Dr. Jurgen Bolz, Institute for general zoology and animal physiology, Friedrich-Schiller-University, Jena, Germany
High honors.

  • 2004-2009 Diploma in Biology       

Diploma thesis: “Functional analysis of the Ephrin/Eph system during the tangential migration of cortical interneurons.”
Supervisor: Prof. Dr. Jurgen Bolz, Institute for general zoology and animal physiology, Friedrich-Schiller-University, Jena, Germany

GRANTS

2018 Brain Behavior Research foundation - Young investigator award (70,000 $ for 2 years)
Title: “Calcium-dependent axon development in cortical Chandelier cells”

2012 Participation award for the “Neurodevelopmental practical course”
Organizer: David VanVector, PhD, Harvard Medical school of Cell Biology 
Okinawa Institute for Science and Technology, Japan

2010 DAAD travel grant 40th annual meeting of the society for neuroscience, San Diego (2,000 €)                     

since 2010 3-years PhD grant of the Graduate academy of the Federal state (1,100 € / month)                      

PUBLICATIONS

  1. Steinecke A and Taniguchi H (2021) Neuromodulatory control of inhibitory network arborization in the nascent neocortex, Science advances, revision submitted
  2. Hayano Y, Ishino Y, Hyun J*, Orozco CG*, Steinecke A*, Potts E, Oisi Y, Thomas CI, Guerrero-Given D, Kim E, Kwon H, Kamasawa N, and Taniguchi H (2021) IgSF11 promotes layer-specific synaptic assembly of the cortical interneuron subtype, Science advances, in revision
  3. Jung K., Steinecke A., Oisi Y., Fitzpatrick D., Taniguchi H., and Kwon H. B. (2021) Chandelier cells shape flexible cortical coding of action through detailed balance control, Nature, submitted
  4. Steinecke A*, Kurabayashi N*, Hayano Y*, Ishino Y, and Taniguchi H (2019) In vivo single cell genotyping of mouse cortical neurons transduced with CRISPR/Cas9, Cell Reports 28, 325 - 331
  5. Ishino Y *, Yetman M J *, Sossi S M, Steinecke A, Hayano Y, and Taniguchi H (2017) Regional Cellular Environment Shapes Phenotypic Variations of Hippocampal and Neocortical Chandelier Cells. The Journal of Neuroscience, 2017, 0047-17
  6. Steinecke A, Hozhabri E, Tapanes S, Ishino Y, Zeng H, Kmasawa N and Taniguchi, H (2017) Neocortical Chandelier Cells Developmentally Shape Axonal Arbors through Reorganization but Establish Subcellular Synapses Specifically without Refinement. eNeuro 4 (3) ENEURO. 0057-17. 2017
  7. Rudolph J, Gerstmann K, Zimmer G, Steinecke A, Döding A, and Bolz J (2014) A dual role for EphB1/ephrin-B3 reverse signaling on migrating striatal and cortical neurons originating in the preoptic area: should I stay or go away? Frontiers in cellular neuroscience, 8: 185
  8. Steinecke A *, Gampe C *, Nitzsche F, and Bolz J (2014) DISC1 knockdown impairs the tangential migration of cortical interneurons by affecting the actin cytoskeleton. Frontiers in cellular neuroscience, 8: 190
  9. Steinecke A, Gampe C, Zimmer G, Rudolph J, and Bolz J (2014) EphA/ephrin-A reverse signaling promotes the migration of cortical interneurons from the medial ganglionic eminence. Development, 141(2):460-71.
  10. Steinecke A *, Gampe C *, Valkova C, Kaether C, and Bolz J (2012) Disrupted-in-Schizophrenia 1 (DISC1) is Necessary for the Correct Migration of Cortical Interneurons. The Journal of Neuroscience, 2012, 32:738-745, Including Cover-Illustration, listed as key-research-article in Psychology Progress
  11. Lehmann K, Steinecke A, and Bolz J (2012) GABA through the ages: Regulation of cortical function and plasticity by inhibitory interneurons. Neuronal Plasticity, 2012:892784
  12. Zimmer G, Rudolph J, Landmann J, Gerstmann K, Steinecke A, Gampe C, and Bolz J (2011) Bidirectional ephrinB3/EphA4 signaling mediates the segregation of MGE- and POA-derived interneurons in the deep and superficial migratory stream. The Journal of Neuroscience, 31:18364-18380 
  13. Zimmer G, Menezes S, Bürger S, Weth F, Steinecke A, Bolz J, and Lent R (2010) The role of Chondroitin sulfate/Sema3A interactions during tangential migration of cortical interneurons. Cerebral Cortex, 10:2411-22
  14. Rudolph J, Zimmer G, Steinecke A, Barchmann S, and Bolz J (2010) Ephrins guide migrating cortical interneurons in the basal telencephalon. Cell Adhesion and Migration, 4:400-408

* equal contribution

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