NeuroTimone Facility (PFNT)

The PFNT Facility is a coherent set of exploration tools in neurobiology allowing research at the molecular, cellular and integrated levels.

News

  1. 1st Congress of the 7 CoENs (International Network of Centers of Excellence in Neurodegeneration)

    Santiago Rivera represented the INP on the 1st Congress of the 7 CoENs (International Neetwork of Centers of Excellence in Neurodegeneration) held in Montpellier on October 18 and 19, 2018, endorsed by AVIESAN: Bordeaux, Grenoble, Lille, Montpellier, Marseille, Paris and Toulouse. He gave a lecture in the CoEN Pathfinder laureates’ session entitled MT-MMPs at the crossroads of amyloidogenesis and neuroinflammation in Alzheimer's disease.

  2. Ludovic Leloup (team cytoskeleton & neurophysiopathology) received a 30 000 € grant from the GEFLUC

    The Emergence project entitled “Tau, from Alzheimer disease to glioblastoma, evolution of a prognostic marker” was selected by the Canceropole PACA to be founded by the GEFLUC (groupement des entreprises françaises dans la lutte contre le cancer). Team 9 has a long-time expertise on Tau and this grant will be used to complete the identification of the kinases responsible for Tau phosphorylation in glioblastoma.

    Photo from the GEFLUC

  3. NeuroSchool: a School of Neuroscience for and by AMU students

    On September 12, over 300 students, teachers, researchers, clinicians and entrepreneurs participated in the launch of NeuroSchool, the school that unifies and harmonizes the teachings of the third year of the bachelor's degree (Neuroscience path), the master's degree and the PhD program in neuroscience. Funded by the National Research Agency and the A*Midex Foundation, NeuroSchool will benefit from a funding of approximately 10 million euros (over 10 years).

  4. Michel Khrestchatisky and Grigorios Kyriatzis (Early Stage Researcher, ESR), both members of the ITN Marie Curie project ECMED participated in the ECMED EU-GliaPhD international conference organized in Malta

    Michel Khrestchatisky gave a talk on the ongoing projects of his group and biotechnology partner Vect-Horus, also member of the ECMED consortium, while Grigorios Kyriatzis presented results of his ongoing PhD project.       

  5. François Devred gave one of the 38 selected talks in EUROTAU 2018

    #EUROTAU 2018 - European scientists involved in Tau research met in Lille to exchange new ideas and hypotheses on physiological and pathological roles of tau proteins (26-27th April 2018). François Devred gave one of the 38 selected talks in which he presented a new reversible oligomerization of tau protein evidenced in INP team 9, which could have a protective physiological role and prevent pathological aggregation of tau in neurodegenerative diseases. Next edition of EuroTau will be in 2020.

    Photo © Valérie Buée Scherrer

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INP in numbers

  • 126 members
  • 44 researchers
  • 48 research assistants
  • 12 post-docs
  • 11 PhD

 

INP team 8 and 9 and PINT members presented their work at the 4th French Microtubule Network

INP team 8 and 9 and PINT members being part of the French Microtubule Network, several members presented their work at the 4th French Microtubule Network gathering in Rennes on the 1srt and 2nd july 2019, in the  "Microtubules and their regulators : new therapeutic targets" session and the "Microtubules, assembly and regulation" session.

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CNRS and Aix-Marseille University sign Agreement with the SME Vect-Horus on the intellectual property

An article entitled "Le CNRS et Aix-Marseille Université signent un accord avec la PME Vect-Horus sur la propriété intellectuelle",  published in the CNRS Innovation Letter of 20 June 2019 and relayed by the INSB site, features the agreement signed by CNRS, AMU and Vect-Horus establishing the intellectual property rights regime and the exploitation of patents.

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The GlioME team published a new article in Stem Cells and one eye-catch figure of their paper was selected for the cover image of the June journal issue!

Our last work on IAPs : "Inhibitor of Apoptosis Proteins (IAPs) Determines Glioblastoma Stem‐Like Cell Fate in an Oxygen‐Dependent Manner" is now published in Stem Cells. We highlighted that pharmacological inhibition of IAPs by Smac mimetic GDC-0152 was able to decrease glioblastoma stem-like cells viability in hypoxia by decreasing cell proliferation and increasing apoptosis through ATR and TNFα pathways

English

INP researchers and students massively attended NeuroFrance 2019

During the last NeuroFrance congress held from May 22 to 24, 2019 at the Palais des Congrès in Marseille, the INP distinguished itself through 20 posters, 4 oral communications, and 1 symposium moderation, not to mention the organization of the "Art in Mind" exhibition, showing not only the richness and quality of his research but also his open-mindedness. 

English

New publication from the NeuroCyto team in Nature Communications: Perform advanced microscopy experiments thanks to NanoJ-Fluidics

The LEGO Pumpy (or more officially NanoJ-Fluidics) paper is out in Nature Communications! A joint venture between the INP NeuroCyto team and the Henriques lab, this article (previously available as a preprint on bioRxiv) details how to build a fully open-source multi-channel syringe pumps with LEGO and Arduino.

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New preprint from the NeuroCyto team: tips and tricks for super-resolution microscopy

We have a new preprint out! Want to do good super-resolution images? We have put together all our single molecule localization microscopy (SMLM) tips and tricks. This is a methods paper that describes our SMLM workflow, using benchmark samples such as microtubules and clathrin-coated pits. 

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New publication from the NeuroCyto team in the Journal of Cell Biology: Slow axonal transport of actin via hotspots and trails

Our latest work (previously on bioRxiv) is now published in the Journal of Cell Biology. We collaborated with the Roy lab (UW Madison, USA) and the Jung lab (Ohio University, USA) to reveal a new mechanism of slow axonal transport, based on our previous discovery of actin hotspots and trails

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Hotspots seen by STORM

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