The PFNT Facility is a coherent set of exploration tools in neurobiology allowing research at the molecular, cellular and integrated levels.
The NeuroCyto team has a new publication out! Published on November 5th in Science, this article elucidates how adenosine A2A receptors drive removal of inhibitory synapses depending on their activity. This is a fruitful collaboration with the labs of Sabine Lévi at Institut du Fer à Moulin (IFM) in Paris and Christophe Bernard at Institut de Neuroscience des Systèmes (INS) in Marseille. Read the article here: https://www.science.org/doi/10.1126/science.abk2055
The NeuroCyto team has a new publication out! Published on Sep. 15 in Neuron, this article reveals how clathrin is slowly transported along axons by forming transport packets that are then docked at presynapses where they can dynamically supply clathrin for synaptic function. This is another episode of the long-standing collaboration between the NeuroCyto team and the lab of Subhojit Roy at UCSD. Read the article here: https://doi.org/10.1016/j.neuron.2021.08.016
Nadia Coliac a été l’auteure, metteuse en scène et scénographe d’une expérience théâtrale bioluminescente qui a eu lieu le 19 octobre dernier à Paris sur la scène des arts et des sciences du théâtre de la Reine Blanche. Une expérience grandeur nature d'éclairer tout un théâtre uniquement avec la lumière vivante qui a captivé le public, ce fut un moment magique !
Cette production artistique et scientifique fait partie de ses recherches dans le domaine de l'histoire des sciences pour réhabiliter la mémoire de " Raphaël Dubois génie de la lampe vivante".
PINT platform recently acquired the NT.Robotic Autosampler that complemented the existing Prometheus NT.Plex nanoDSF instrument which is already equipped with aggregation detection optics to get complete stability characterization.
NT.Robotic Autosampler is a stand-alone, all-inclusive system with robotic arm, computer, and monitor. PINT is now able to analyze up to 1,536 samples for hands-free characterization of thermal unfolding and chemical denaturation in a single experiment. Incorporate plate temperature control to keep your samples at 4 to 20 °C while they wait in the queue.
This will permit to scale up the existing applications of the Prometheus :
Romain La Rocca, former member of INP team 9, shared the stage of EuroTau meeting in Lille's Grand Palais with Illana Gozes (Israel), Cláudio M. Gomes (Portugal), Amandine Grimm (Switzerland), Yann Fichou (France), Marina Rierola (Germany), Laura Vallés Saiz (Spain), Marie Galas (France) and Mahmoud Maina (UK / USA) during Session #3 chaired by Isabelle Landrieu & Yann Fichou.
He presented his PhD work on the Three zinc binding sites of Tau and their role in tau aggregation and little bit of the perspectives Dahbia Yatoui is currently working on right now.
On October, the 21st, Emmanuel was invited to give a talk during the 2021 meeting organized by the French Club of Glial Cells. Emmanuel had the chance to present the latest and exciting results of the NIVET team by giving a talk during a symposium dedicated on Glial cells in Brain diseases. Emmanuel's talk was entitled: "Human-iPSC-astrocytes reveal a pro-inflammatory axis under the control of the APOE4 genetic risk factor in Alzheimer's disease".
Félicitations à Chiara Bastiancich, post-doctorante dans l'équipe GlioME qui a obtenu la bourse de recherche fondamentale Élie Bzoura 2021, délivrée par la Société Française de Pharmacie Oncologique et à l' Académie nationale de Pharmacie pour son projet GlioRET.
Congratulations to Chiara Bastiancich, post-doctoral fellow in the GlioME team who has been awarded the Élie Bzoura research grant by the French Society of Oncology Pharmacy and the French National Academy of Pharmacy for her GlioRET project.
Aurélie Tchoghandjian (équipe 8 - GlioME) a obtenu un financement "Emergence" pour son projet intitulé "Création d’une lignée syngénique murine de cellules souches de glioblastome reproduisant l’hétérogénéité moléculaire et cellulaire des glioblastomes pour combattre la résistance thérapeutique" et Gilles Breuzard (équipe 9 - Cytosquelette et Physiopathologie) pour son projet intitulé "La protéine Tau comme nouvelle cible thérapeutique des glioblastomes : focus sur de nouveaux dérivés des thiazoloflavones "
The Cytoskeleton & Neurophysiopathology team and the GlioME team have a new publication out! Published on November 19th in Cancers, this article gives insights into how Tau regulates glioblastoma progression, via the PI3K-AKT signaling pathway.
Read the article here: https://www.mdpi.com/2072-6694/13/22/5818
On November 25 and 26, the conference "Digital Sciences and Artificial Intelligence for Health at Aix-Marseille University" was held in the Grisoli amphitheater & the Great Hall of the Faculty of Medical and Paramedical Sciences - Timone.
The aim of this conference was to formally bring together for the first time all the actors of Aix-Marseille University and the University Hospital Center involved in the digital and AI/health field, whether they are clinicians or theoreticians.
Plusieurs chercheurs de la communauté marseillaise des neurosciences, notamment l’équipe d’Agnès Trébuchon, mènent des recherches sur les fondamentaux et les effets thérapeutiques de la transe cognitive auto-induite. Tout comme l’hypnose ou la méditation, il s’agit d’un état modifié de conscience, induit par la seule volonté de chacun.
Neural Plasticity and Degeneration team has recently welcomed Shweta SONAWANE.
Shweta is from Mumbai (India) she did her Ph.D. at the Biochemical sciences division of CSIR - National Chemical Laboratory in Pune (India).
Her doctoral research was largely focused on Tau pathology in Alzheimer’s disease studying in particular the effect of glycated and phosphorylated Tau on cytoskeleton integrity as well as aggregation propensity in order to find small molecules that could attenuate Tau aggregation and prevent its glycation.
The NeuroCyto lab is looking to hire a postdoctoral fellow for an exciting project bridging the nanoscale architecture of axons and their cellular functioning!
About the position and project
The NeuroCyto team has a new publication out! Published on November 5th in Science, this article elucidates how adenosine A2A receptors drive removal of inhibitory synapses depending on their activity. This is a fruitful collaboration with the labs of Sabine Lévi at Institut du Fer à Moulin (IFM) in Paris and Christophe Bernard at Institut de Neuroscience des Systèmes (INS) in Marseille.
The NeuroCyto team has a new publication out! Published on Sep. 15 in Neuron, this article reveals how clathrin is slowly transported along axons by forming transport packets that are then docked at presynapses where they can dynamically supply clathrin for synaptic function. This is another episode of the long-standing collaboration between the NeuroCyto team and the lab of Subhojit Roy at UCSD. Read the article here: https://doi.org/10.1016/j.neuron.2021.08.016
L’institut de NeuroPhysiopathologie (INP) CNRS UMR_7051 est un centre d’excellence de formation et de recherche au sein de Aix-Marseille Université (site Timone) qui combine la recherche fondamentale et translationnelle pour étudier l’organisation, la fonction et l’interaction des cellules neuronales, ainsi que les bases moléculaires et cellulaires des principales maladies du cerveau.
La force de l’INP
Développer des stratégies thérapeutiques cellulaires et moléculaires innovantes.
Rejoignez-nous !
Nadia Coliac a été l’auteure, metteuse en scène et scénographe d’une expérience théâtrale bioluminescente qui a eu lieu le 19 octobre dernier à Paris sur la scène des arts et des sciences du théâtre de la Reine Blanche. Une expérience grandeur nature d'éclairer tout un théâtre uniquement avec la lumière vivante qui a captivé le public, ce fut un moment magique !
PINT platform recently acquired the NT.Robotic Autosampler that complemented the existing Prometheus NT.Plex nanoDSF instrument which is already equipped with aggregation detection optics to get complete stability characterization.
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