The Institute of NeuroPhysiopathology (INP) is a training and research centre of excellence that combines basic and translational research to study neural cell organisation, function and interaction, the molecular and cellular bases of major brain diseases, and to develop innovative cellular and molecular therapeutic strategies.
The PFNT Facility is a coherent set of exploration tools in neurobiology allowing research at the molecular, cellular and integrated levels.
In collaboration with the Holtzman lab., Maud Gratuze, with her colleagues Monica Xiong and Chao Wang, published an article on a project developed during her postdoc in the USA. In this study, entitled "Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy" and recently published in Molecular Neurodegeneration, they reduced ApoE4, the strongest genetic risk factor in Alzheimer’s disease, specifically derived from astrocytes in a mouse model of cerebral amyloid angiopathy.
INP and C2VN are organizing the next seminar in the framework of the seminar series of the Institute of Cancer and Immunology (ICI). This day will take place on Tuesday March 7th, 2023 on the Timone campus (Faculté des Sciences Médicales et Paramédicales, amphi 4). We will have the pleasure to welcome Pr Etienne Meylan (PhD, Belgium) who will be giving a seminar entitled "Tumor-associated neutrophils in the immunotherapy era". His research work focuses on neutrophils and lung cancer.
INP, more precisely PINT platform, along with 13 laboratories and institutes affiliated with AMU (*) is co-organizing the 3rd Integrative Structural Biology meeting (BSI 2023) with the Association Française de Cristallographie (AFC) and the Société Française de Biophysique (SFB). The meeting will take place in Marseille in the Faculty of Medical Sciences on the Timone Campus on November 13-17, 2023.
Save the date and follow us on Twitter (@BSI2023) for updated information!
INP, Molecular Interaction & Pharmacology (team 9) and GlioME: Gliomagenesis and MicroEnvironment (team 8) are glad to share the release of their new work "Plasma nanoDSF Denaturation Profile at Baseline Is Predictive of Glioblastoma EGFR Status" which was done in collaboration with data scientists from Laboratoire Hubert Curien, UJM-Saint-Etienne and Laborat
On december 10th 2022, PINT INP and Vect-Horus members met in the Hippodrome Borély for the "Course des Lumières" organized by Foundation Recherche Alzheimer. It was freezing but together with 600 or something others, they walked 5 km or ran 8 km, to light up the night against Alzheimer's disease and for all patients, carrying a luminous object. See a few pictures below
Simple Summary
The Cancéropole PACA has created a web page for the PETRA platform with all the necessary information and the contact form: PETRA web page.
In collaboration with other teams, the glioME team participated in two new scientific publications:
"Deciphering the heterogeneity of the Lyve1+ perivascular macrophages in the mouse brain": https://www.nature.com/articles/s41467-022-35166-9
"Challenges in glioblastoma research: focus on the tumor microenvironment": https://pubmed.ncbi.nlm.nih.gov/36400694/
Team 8 has recently obtained a CMA-CGM funding in the framework of the call for projects "Programme d'équipement et de recherche clinique" 2022
The project title is "Program of Precision RAdioTherapy to Improve patient Cancer treatment" and aims to participate in the purchase of a small animal irradiator "SARRP" that will complement the pre-clinical offerings of the PETRA network.
Team 9 represented by José Luis and team 8 represented by Aurélie Tchoghandjian have obtained Amidex Blanc funding for the project: "Bioinspired cytotoxic copper complexes: deciphering their mechanism of action in cancer cells to develop efficient therapeutic agents (CytoCu4Cancer)".
This project is led by a chemist, Olga Iranzo of the Institute of Molecular Sciences of Marseille (iSm2).
RESEARCH FIELD(S)
Depuis lundi 3 Avril, l'INP participe à une opération inter-laboratoires de quantification de déchets recyclables professionnels (et ménagers) sur le campus Timone.
Pour cela, chaque aile a été aménagée avec des points de collecte et de tri sélectif. Chaque semaine, les différentes catégories seront pesées puis emmenées au recyclage pour valorisation.
Comme chaque année les membres de l'INP participent à la semaine du cerveau. Parmi les actions de cette année on peut citer l'intervention de Cynthia et Charbel deux doctorants de l'équipe 9 qui sont allés rendre visite à l'école primaire du Pharo Catalans
In collaboration with the Holtzman lab., Maud Gratuze, with her colleagues Monica Xiong and Chao Wang, published an article on a project developed during her postdoc in the USA. In this study, entitled "Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy" and recently published in Molecular Neurodegeneration, they reduced ApoE4, the strongest genetic risk factor in Alzheimer’s disease, specifically derived from astrocytes in a mouse model of cerebral amyloid angiopathy.
RESEARCH FIELD(S) AND DISCIPLINES
Neurosciences
Biological sciences
JOB /OFFER DESCRIPTION
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