NeuroTimone Facility (PFNT)

The PFNT Facility is a coherent set of exploration tools in neurobiology allowing research at the molecular, cellular and integrated levels.

News

  1. New publication from the GlioME Team (INP team 8) in Cancers pointing at A2B5 as an attractive therapeutic target for glioblastomas.
  2. F. Devred and E. Tabouret presented their research work at the annual Canceropole PACA meeting
  3. INP team 8 and 9 and PINT members presented their work at the 4th French Microtubule Network

    INP team 8 and 9 and PINT members being part of the French Microtubule Network, several members presented their work at the 4th French Microtubule Network gathering in Rennes on the 1srt and 2nd july 2019, in the  "Microtubules and their regulators : new therapeutic targets" session and the "Microtubules, assembly and regulation" session. Pascale Barbier presented her work "", Raphael Berges his work "Proscillaridin A exerts anti-tumor effects through"GSK3 activation and alteration of microtubule dynamics in glioblastoma" and François Devred a new method of "Functional screening of therapeutic agents and targets using nanoDSF "

  4. CNRS and Aix-Marseille University sign Agreement with the SME Vect-Horus on the intellectual property

    An article entitled "Le CNRS et Aix-Marseille Université signent un accord avec la PME Vect-Horus sur la propriété intellectuelle",  published in the CNRS Innovation Letter of 20 June 2019 and relayed by the INSB site, features the agreement signed by CNRS, AMU and Vect-Horus establishing the intellectual property rights regime and the exploitation of patents.

  5. The GlioME team published a new article in Stem Cells and one eye-catch figure of their paper was selected for the cover image of the June journal issue!

    Our last work on IAPs : "Inhibitor of Apoptosis Proteins (IAPs) Determines Glioblastoma Stem‐Like Cell Fate in an Oxygen‐Dependent Manner" is now published in Stem Cells. We highlighted that pharmacological inhibition of IAPs by Smac mimetic GDC-0152 was able to decrease glioblastoma stem-like cells viability in hypoxia by decreasing cell proliferation and increasing apoptosis through ATR and TNFα pathways

  6. INP researchers and students massively attended NeuroFrance 2019

    During the last NeuroFrance congress held from May 22 to 24, 2019 at the Palais des Congrès in Marseille, the INP distinguished itself through 20 posters, 4 oral communications, and 1 symposium moderation, not to mention the organization of the "Art in Mind" exhibition, showing not only the richness and quality of his research but also his open-mindedness. 

  7. The CNRS features Vect-Horus and the INP in the Innovation Letter of April

    In the CNRS Innovation Letter of April, there is an article entitled "Des molécules vectorisées pour cibler les maladies neurodégénératives" featuring the research collaboration agreement signed by Vect-Horus and Johnson & Johnson subsidiary Janssen Pharmaceuticals for treating neurodegenerative diseases.

  8. INP students presented their research work at the 14th International Conference on Alzheimer's and Parkinson's Diseases (ADPD)

    On the 26-31st March, the 14th International Conference on Alzheimer's and Parkinson's Diseases (ADPD) and related neurological disorders was held in Lisbon, Portugal. This year, almost the entire team 1 and team 6 went to this major event and our students: Laurie Arnaud, Laura García González and Dominika Pilat took the opportunity to present their work on a poster.

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INP in numbers

  • 126 members
  • 44 researchers
  • 48 research assistants
  • 12 post-docs
  • 11 PhD

 

New publication from the NeuroCyto team in Nature Communications: Perform advanced microscopy experiments thanks to NanoJ-Fluidics

The LEGO Pumpy (or more officially NanoJ-Fluidics) paper is out in Nature Communications! A joint venture between the INP NeuroCyto team and the Henriques lab, this article (previously available as a preprint on bioRxiv) details how to build a fully open-source multi-channel syringe pumps with LEGO and Arduino.

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New preprint from the NeuroCyto team: tips and tricks for super-resolution microscopy

We have a new preprint out! Want to do good super-resolution images? We have put together all our single molecule localization microscopy (SMLM) tips and tricks. This is a methods paper that describes our SMLM workflow, using benchmark samples such as microtubules and clathrin-coated pits. 

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New publication from the NeuroCyto team in the Journal of Cell Biology: Slow axonal transport of actin via hotspots and trails

Our latest work (previously on bioRxiv) is now published in the Journal of Cell Biology. We collaborated with the Roy lab (UW Madison, USA) and the Jung lab (Ohio University, USA) to reveal a new mechanism of slow axonal transport, based on our previous discovery of actin hotspots and trails

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Hotspots seen by STORM

The GlioME team has popularized a scientific article to make its research accessible to the general public.

The popularization of science is one of the missions of academic research. This article authored by Aurélie Soubéran is intended for children aged 12-13 years and more broadly for the general public, and focuses on a preclinical study on glioblastoma model.

To access it, please download the pdf version.

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Vect-Horus and RadioMedix announce signing of a Letter of Intent to co-develop a radio-theranostic agent for Glioblastoma

This partnership will marry the expertise of Vect-Horus in targeting tumors with its technology VECTrans® and the know-how of RadioMedix in developing and conducting pre-clinical evaluation and clinical trials with radiopharmaceuticals.

For more information, please follow this link or download the pdf version.

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Michel Khrestchatisky gives a talk at the « Nanomedicine for treating cancer and brain diseases » symposium

In the context of the Euronanomed projects for Action on Nanomedicine under Horizon 2020, a Symposium will be held at the Luminy campus in Marseille on March 8, 2019. Dr. Khrestchatisky will give a talk titled "Molecular vectors for drug delivery into the brain and tumors".

For more information, please visit the symposium website or download the pdf version of the program.

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Yvon Berland mentions Vect-Horus as one of the three 3 AMU biotech success stories

In an interview published by "La Provence" on November 30, 2018 Yvon Bertrand, President of Aix-Marseille University, explains that AMU is very proud of its contribution to the field of Artificial Intelligence but also to the development of companies such as "First Light Imaging", VECT-HORUS or Innate-Pharma. They are real success stories from public research.

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INP Team 9 participated in a joint review on Tau molecular structures

INP Cytoskeleton and Neurophysiopathology team, together with several leading groups in tau biology, has participated in a joint review of the field that just came out in Acta Neuropathologica Communications. This review summarizes the recent breakthroughs in deciphering the molecular structures, both physiological and pathological, of the elusive protein tau. 

Read online (open access) : https://link.springer.com/article/10.1186/s40478-019-0682-x

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