Job offers

Platform engineer : Conformational stability of proteins and protein ligands interactions

The Platform Interactome Timone of the Institute of Neurophysiopathology (INP) located at the Medical Faculty of AMU at Timone campus (Marseille) is seeking a dynamic and talented engineer with strong background in biophysical methods and protein biochemistry for participation in several interdisciplinary projects. Our unit uses biophysical techniques (Isothermal titration calorimetry, differential scanning calorimetry, differential scanning fluorimetry, dynamic light scattering, surface plasmon resonance etc.) to study the molecular mechanisms implicated in neurodegeneration and to develop new diagnostic methods.

The engineer will be involved in developing a novel universal diagnostic method based on denaturation profiles of human plasma samples that will be analyzed with the help of machine learning algorithms. Also, he/she will participate in the screening of a large library of inhibitors of protein-protein interactions to find new compounds that impact microtubular cytoskeleton.

The ideal candidate must have skills in biophysical methods, molecular biology, and biochemistry.
The position is opened for one year, renewable up to 2 years starting  from september 2021. Net wage : 1500-1800 net
Address : Plateforme PINT, Institut de NeuroPhsyiopathology, UMR 7051, Faculté des Sciences Médicales et Paramédicales, 27 Bd Jean Moulin, 13005 Marseille
website : https://inp.univ-amu.fr/en/facilities/pint

Applicants must email a CV, a statement of interest and contact details for 2-3 references to francois.devred@univ-amu.fr

Relevant publications:

2020     An AI-powered blood test to detect cancer using nanoDSF

2020     In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor

2019     Plasmatic Signature of Disease by Differential Scanning Calorimetry (DSC)

2018     Differential scanning calorimetry of plasma in glioblastoma: toward a new prognostic/monitoring tool

The Institute of NeuroPhysiopathology (INP) in Marseille is recruiting a research engineer to study subcellular relations between APP and MT5-MMP in Alzheimer's disease

Beginning June 2021; duration 2 years; funded by the Vaincre Alzheimer Foundation

A two-year position as a research engineer is available from June 1, 2021 at the Institute of Neurophysiopathology (INP, University of Aix-Marseille/CNRS) in the team of Dr. Santiago Rivera who studies the physiopathological mechanisms of Alzheimer's disease. The project is developed in collaboration with the NeuroCyto team of Dr Christophe Leterrier also at INP.
The candidate will be involved in a project aimed at elucidating the molecular and subcellular relationships between the MT5-MMP protease and the amyloid precursor protein (APP) in neurons. For this, different approaches will be used, with protein expression by viral vectors in cultured neurons followed by live-cell, super-resolution and HCS microscopy as well as biochemical studies. Experience in one or more of these techniques, especially microscopy, will be appreciated. In addition, experience in molecular biology or data analysis with bioinformatics tools could be useful.
The candidate should have a master's degree or engineering degree in biomedical or biotechnological sciences, be enthusiastic and well-organized, have a taste for detail, a good analytical and learning capacity, be willing to work in a team and have good interpersonal and communication skills.
Applications must be written in French or English and contain: 1) A curriculum vitae. 2) A coverletter. 3) Two letters of reference.
Please send applications no later than March 10 to Dr. Santiago Rivera and Dr. Christophe Leterrier at the following e-mail addresses: santiago.rivera@univ-amu.fr / christophe.leterrier@univ-amu.fr.

Postdoctoral position at the Institute of Neurophysiopathology (INP) Marseille

A 3-year full-time postdoc position is open at the Institute of Neuropathophysiology (INP), CNRS/Aix-Marseille University to study pathogenic mechanisms of Alzheimer’s disease. The project should start in spring 2021.

The pioneering work from Dr. Rivera and Dr. Khrestchatisky’s teams suggests that metalloproteinase MT5-MMP could be a novel target in Alzheimer’s disease. The project includes the study of the mechanisms of action involved in the detrimental effects action of MT5-MMP and the identification of molecules that may antagonize such effects in cells and mice. We will use heterologous cells, iPS-derived neural cells and transgenic Alzheimer mice, as well as AAVs, conjugated peptide vectors/biomolecules and phenotypic cell/tissue analysis, using approaches of molecular and cell biology, biochemistry, advanced microscopy and histopathology.

Requirements:

  • Hold a PhD in neuroscience, biotechnology or pharmacological sciences.
  • Be highly motivated and qualified, with skills in cell and molecular biology, biochemistry and imaging analysis. Complementary knowledge in neurodegenerative diseases and skills in data management will be also appreciated.
  • Excellent oral and written communication skills in English.
  • Leadership, organizational and social skills to work in groups and independently.

The INP offers an internationally competitive environment with state-of-the-art facilities shared with the biotechnology company Vect-Horus. The postdoc will be co-supervised by Dr. Santiago Rivera and Dr. Michel Khrestchatisky and will also work in interaction with the scientific and technical staff of Vect-Horus. The project will be developed at the Faculty of Medicine, a few kilometres from the Calanques National Park and the charms of Provence.
Salary & benefits: between 24 and 30 k€/year depending on experience; full health and social coverage.
Please, send a PDF file with a CV, a cover letter indicating major interests and research experience, a list of publications and 3 reference letters or contact information of former supervisors to Dr. Santiago Rivera santiago.rivera@univ-amu.fr.
 

Deadline: March 20th.