Offres d'emploi

The Institute of NeuroPhysiopathology (INP) in Marseille is recruiting a research engineer to study subcellular relations between APP and MT5-MMP in Alzheimer's disease

Beginning June 2021; duration 2 years; funded by the Vaincre Alzheimer Foundation

A two-year position as a research engineer is available from June 1, 2021 at the Institute of Neurophysiopathology (INP, University of Aix-Marseille/CNRS) in the team of Dr. Santiago Rivera who studies the physiopathological mechanisms of Alzheimer's disease. The project is developed in collaboration with the NeuroCyto team of Dr Christophe Leterrier also at INP.
The candidate will be involved in a project aimed at elucidating the molecular and subcellular relationships between the MT5-MMP protease and the amyloid precursor protein (APP) in neurons. For this, different approaches will be used, with protein expression by viral vectors in cultured neurons followed by live-cell, super-resolution and HCS microscopy as well as biochemical studies. Experience in one or more of these techniques, especially microscopy, will be appreciated. In addition, experience in molecular biology or data analysis with bioinformatics tools could be useful.
The candidate should have a master's degree or engineering degree in biomedical or biotechnological sciences, be enthusiastic and well-organized, have a taste for detail, a good analytical and learning capacity, be willing to work in a team and have good interpersonal and communication skills.
Applications must be written in French or English and contain: 1) A curriculum vitae. 2) A coverletter. 3) Two letters of reference.
Please send applications no later than March 10 to Dr. Santiago Rivera and Dr. Christophe Leterrier at the following e-mail addresses: santiago.rivera@univ-amu.fr / christophe.leterrier@univ-amu.fr.

L’institut de NeuroPhysiopathologie (INP) à Marseille recrute un ingénieur d’études pour étudier les relations subcellulaires entre APP et MT5-MMP dans la maladie d'Alzheimer

Début Juin 2021 ; durée 2 ans ; financement Fondation Vaincre Alzheimer

Un poste d'ingénieur d'études pendant deux ans est disponible à partir du 1er juin 2021 à l'Institut de Neurophysiopathologie (INP, Universitéd'Aix-Marseille/CNRS) dans l’équipe du Dr Santiago Rivera qui étudie les mécanismes physiopathologiques de la maladie d'Alzheimer. Le projet est développé en collaboration avec l'équipe NeuroCyto du Dr Christophe Leterrier également au sein de l’INP.
Le candidat sera impliqué dans un projet visant à élucider les relations moléculaires et subcellulaires entre la protéase MT5-MMP et la protéine précurseur amyloïde (APP) dans les neurones. Pour cela, différentes approches seront utilisées, avec l’expression de protéines par vecteurs viraux dans des neurones en culture suivi d’observations en microscopie live-cell, super-résolution et HCS ainsi que d’études biochimiques. Une expérience dans une ou plusieurs de ces techniques, en particulier la microscopie, sera appréciée. En complément, une expérience en biologie moléculaire ou en analyse de données avec des outils bio-informatiques pourrait être utile.
Le candidat doit être titulaire d’un master ou d'un diplôme d'ingénieur en sciences biomédicales ou biotechnologiques, être enthousiaste et bien organisé, avoir le goût du détail, une bonne capacité d’analyse et d’apprentissage, être disposé à travailler en équipe et avoir de bonnes capacités relationnelles et de communication.
Les candidatures doivent être rédigées en français ou en anglais et contenir : 1) Un curriculum vitae. 2) Une lettre de motivation. 3) Deux lettres de référence.
Veuillez envoyer les candidatures au plus tard le 10 mars au Dr Santiago Rivera et au Dr Christophe Leterrier aux adresses électroniques suivantes : santiago.rivera@univ-amu.fr / .

Postdoctoral position at the Institute of Neurophysiopathology (INP) Marseille

A 3-year full-time postdoc position is open at the Institute of Neuropathophysiology (INP), CNRS/Aix-Marseille University to study pathogenic mechanisms of Alzheimer’s disease. The project should start in spring 2021.

The pioneering work from Dr. Rivera and Dr. Khrestchatisky’s teams suggests that metalloproteinase MT5-MMP could be a novel target in Alzheimer’s disease. The project includes the study of the mechanisms of action involved in the detrimental effects action of MT5-MMP and the identification of molecules that may antagonize such effects in cells and mice. We will use heterologous cells, iPS-derived neural cells and transgenic Alzheimer mice, as well as AAVs, conjugated peptide vectors/biomolecules and phenotypic cell/tissue analysis, using approaches of molecular and cell biology, biochemistry, advanced microscopy and histopathology.

Requirements:

  • Hold a PhD in neuroscience, biotechnology or pharmacological sciences.
  • Be highly motivated and qualified, with skills in cell and molecular biology, biochemistry and imaging analysis. Complementary knowledge in neurodegenerative diseases and skills in data management will be also appreciated.
  • Excellent oral and written communication skills in English.
  • Leadership, organizational and social skills to work in groups and independently.

The INP offers an internationally competitive environment with state-of-the-art facilities shared with the biotechnology company Vect-Horus. The postdoc will be co-supervised by Dr. Santiago Rivera and Dr. Michel Khrestchatisky and will also work in interaction with the scientific and technical staff of Vect-Horus. The project will be developed at the Faculty of Medicine, a few kilometres from the Calanques National Park and the charms of Provence.
Salary & benefits: between 24 and 30 k€/year depending on experience; full health and social coverage.
Please, send a PDF file with a CV, a cover letter indicating major interests and research experience, a list of publications and 3 reference letters or contact information of former supervisors to Dr. Santiago Rivera santiago.rivera@univ-amu.fr.
 

Deadline: March 20th.

The Institute of NeuroPhysiopathology (INP) welcomes tenured researchers/lecturers, and junior researchers to lead or strengthen its research programmes

The Institute of NeuroPhysiopathology (INP) is a new laboratory of the CNRS/Aix-Marseille University created in 2018 that combines fundamental and translational research in a stimulating and friendly working environment (https://inp.univ-amu.fr). The INP is located on the Health Sciences Campus of La Timone, which is home to other leading neuroscience laboratories, bringing together more than 400 people covering a wide range of topics.

The INP seeks to attract the next generation of neuroscientists to explore new frontiers in human brain diseases (e.g., neurodegenerative diseases, brain cancer), the organisation of the neuronal cytoskeleton, cell reprogramming and disease modelling, brain-immune system crosstalk, neuron-glia interactions, blood brain barrier dysfunctions and the basis of cognition and circadian rhythms.

The INP is looking for two types of profiles:

1) Researchers and university lecturers holding a permanent position in France, interested in leading an independent research team or wishing to join existing teams.

2) Junior researchers looking for a permanent position in France to lead independent and innovative research programmes. We strongly encourage applications from candidates meeting the criteria to apply for ATIP-Avenir or European funded (e.g., ERC) programmes. We offer support and guidance in preparing applications for grants and permanent positions.

Candidates should send their application before 15 January 2021 in a single PDF file to the director of the laboratory, Dr Michel Khrestchatisky ( ) and to the deputy director, Dr Santiago Rivera ( ). Applications must include a CV and a cover letter describing current and future scientific endeavours.

The INP is a Laboratoire Commun de Recherche (Labcom) that offers an internationally competitive research environment in partnership with the biotechnology spin-off company Vect-Horus (https://www.vect-horus.com). The state-of-the-art technological facilities include super/high resolution and high throughput AI-based microscopy (STORM, SIM, SoRa, HCS), an iPS cell platform, and a biophysical platform specialized in molecular interactions (SPR, DSC, DSF, ITC, AUC and mass spectrometry). INP staff also have access to other cutting edge facilities on campus, including live 2-photon and electron microscopy, virus production and utilization facilities (A2-A3), functional imaging (MRI) and a brand new SPF rodent facility with space for surgery and animal behaviour studies. Hospital centres located near the campus facilitate interactions with clinicians, notably through the DHUNE federation of laboratories associated with the Centre of Excellence in Neurodegeneration (CoEN) (https://www.coen.org), of which the INP is a member.

The INP is a member of NeuroMarseille (https://neuro-marseille.org), a network of excellence that brings together scientists, clinicians and entrepreneurs, representing the 2nd largest neuroscience community in France. Within the framework of Aix-Marseille University, the INP is integrated into the new European University, CIVIS (https://civis.eu/fr), thus promoting scientific and training synergies in a rich and dynamic international environment. The INP is also part of the Institute of Oncology and Immunology and the Imaging Institute for Biology and Medicine of Marseille, which underlines its interdisciplinary character.

INP staff is actively involved in undergraduate teaching, as well as in the international PhD program through NeuroSchool, the Graduate School of Neuroscience (https://neuro-marseille.org/en/training/), which offers scholarships to foreign master and PhD students wishing to work in a NeuroMarseille laboratory.

Finally, the INP is located in the centre of Marseille, a few kilometres from the magnificent Parc National des Calanques and the scenic and cultural charms of Provence, a perfect complement to the dynamism of Marseille and its region as a place to live and do science.

 

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Platform engineer : Conformational stability of proteins and protein ligands interactions

The Platform Interactome Timone of the Institute of Neurophysiopathology (INP) located at the Medical Faculty of AMU at Timone campus (Marseille) is seeking a dynamic and talented engineer with strong background in biophysical methods and protein biochemistry for participation in several interdisciplinary projects. Our unit uses biophysical techniques (Isothermal titration calorimetry, differential scanning calorimetry, differential scanning fluorimetry, dynamic light scattering, surface plasmon resonance etc.) to study the molecular mechanisms implicated in neurodegeneration and to develop new diagnostic methods.

The engineer will be involved in developing a novel universal diagnostic method based on denaturation profiles of human plasma samples that will be analyzed with the help of machine learning algorithms. Also, he/she will participate in the screening of a large library of inhibitors of protein-protein interactions to find new compounds that impact microtubular cytoskeleton.

The ideal candidate must have skills in biophysical methods, molecular biology, and biochemistry.
The position is opened for one year, renewable up to 3 years starting as early as January 2021. Net wage : 1500-1800 net
Address : Plateforme PINT, Institut de NeuroPhsyiopathology, UMR 7051, Faculté des Sciences Médicales et Paramédicales, 27 Bd Jean Moulin, 13005 Marseille
website : https://inp.univ-amu.fr/en/facilities/pint

Applicants must email a CV, a statement of interest and contact details for 2-3 references to francois.devred@univ-amu.fr

Relevant publications:

2020     An AI-powered blood test to detect cancer using nanoDSF

2020     In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor

2019     Plasmatic Signature of Disease by Differential Scanning Calorimetry (DSC)

2018     Differential scanning calorimetry of plasma in glioblastoma: toward a new prognostic/monitoring tool