Dr André Steinecke, Ph.D. Research Fellow Dr. Hiroki Taniguchi’s Laboratory – Development and Function of Inhibitory Neural Circuits, will give a seminar entitled "Neuromodulatory Control of Network Arborization in the Developing Neocortex.” friday 19th march at 14h30 via  Zoom

RESEARCH STATEMENT

My broad research interest is to study the development of inhibitory cortical circuits from migration and integration of interneurons to plasticity and function. During my current project, I discovered a mechanism by which acetylcholinergic neuromodulation shapes the integration of Cortical Chandelier cells through activation of voltage-gated calcium channels. My long-term goal is to understand principles of the self-organization of inhibitory neural circuits in health and disease.       

EDUCATION

• 2013 – Present Research Fellow at Max Planck Florida Institute    Jupiter, FL

Dr. Hiroki Taniguchi’s Laboratory - Development and Function of Inhibitory Neural Circuit       
“Activity-Dependent development of Cortical Interneurons with a special focus on the Neuromodulatory Control of the postnatal Network Integration of Cortical Chandelier Cells.”

• 2009-2013 PhD, Neuroscience      

Dissertation: “The role of the gene Disrupted-in-Schizophrenia-1 (DISC1) during the tangential migration of cortical interneurons in mice.”
Supervisor: Prof. Dr. Jurgen Bolz, Institute for general zoology and animal physiology, Friedrich-Schiller-University, Jena, Germany
High honors.

• 2004-2009 Diploma in Biology       

Diploma thesis: “Functional analysis of the Ephrin/Eph system during the tangential migration of cortical interneurons.”
Supervisor: Prof. Dr. Jurgen Bolz, Institute for general zoology and animal physiology, Friedrich-Schiller-University, Jena, Germany

GRANTS

2018 Brain Behavior Research foundation - Young investigator award (70,000 $ for 2 years)
Title: “Calcium-dependent axon development in cortical Chandelier cells”

2012 Participation award for the “Neurodevelopmental practical course”
Organizer: David VanVector, PhD, Harvard Medical school of Cell Biology 
Okinawa Institute for Science and Technology, Japan

2010 DAAD travel grant 40th annual meeting of the society for neuroscience, San Diego (2,000 €)                     

since 2010 3-years PhD grant of the Graduate academy of the Federal state (1,100 € / month)                      

PUBLICATIONS

1. Steinecke A and Taniguchi H (2021) Neuromodulatory control of inhibitory network arborization in the nascent neocortex, Science advances, revision submitted
2. Hayano Y, Ishino Y, Hyun J*, Orozco CG*, Steinecke A*, Potts E, Oisi Y, Thomas CI, Guerrero-Given D, Kim E, Kwon H, Kamasawa N, and Taniguchi H (2021) IgSF11 promotes layer-specific synaptic assembly of the cortical interneuron subtype, Science advances, in revision
3. Jung K., Steinecke A., Oisi Y., Fitzpatrick D., Taniguchi H., and Kwon H. B. (2021) Chandelier cells shape flexible cortical coding of action through detailed balance control, Nature, submitted
4. Steinecke A*, Kurabayashi N*, Hayano Y*, Ishino Y, and Taniguchi H (2019) In vivo single cell genotyping of mouse cortical neurons transduced with CRISPR/Cas9, Cell Reports 28, 325 - 331
5. Ishino Y *, Yetman M J *, Sossi S M, Steinecke A, Hayano Y, and Taniguchi H (2017) Regional Cellular Environment Shapes Phenotypic Variations of Hippocampal and Neocortical Chandelier Cells. The Journal of Neuroscience, 2017, 0047-17
6. Steinecke A, Hozhabri E, Tapanes S, Ishino Y, Zeng H, Kmasawa N and Taniguchi, H (2017) Neocortical Chandelier Cells Developmentally Shape Axonal Arbors through Reorganization but Establish Subcellular Synapses Specifically without Refinement. eNeuro 4 (3) ENEURO. 0057-17. 2017
7. Rudolph J, Gerstmann K, Zimmer G, Steinecke A, Döding A, and Bolz J (2014) A dual role for EphB1/ephrin-B3 reverse signaling on migrating striatal and cortical neurons originating in the preoptic area: should I stay or go away? Frontiers in cellular neuroscience, 8: 185
8. Steinecke A *, Gampe C *, Nitzsche F, and Bolz J (2014) DISC1 knockdown impairs the tangential migration of cortical interneurons by affecting the actin cytoskeleton. Frontiers in cellular neuroscience, 8: 190
9. Steinecke A, Gampe C, Zimmer G, Rudolph J, and Bolz J (2014) EphA/ephrin-A reverse signaling promotes the migration of cortical interneurons from the medial ganglionic eminence. Development, 141(2):460-71.
10. Steinecke A *, Gampe C *, Valkova C, Kaether C, and Bolz J (2012) Disrupted-in-Schizophrenia 1 (DISC1) is Necessary for the Correct Migration of Cortical Interneurons. The Journal of Neuroscience, 2012, 32:738-745, Including Cover-Illustration, listed as key-research-article in Psychology Progress
11. Lehmann K, Steinecke A, and Bolz J (2012) GABA through the ages: Regulation of cortical function and plasticity by inhibitory interneurons. Neuronal Plasticity, 2012:892784
12. Zimmer G, Rudolph J, Landmann J, Gerstmann K, Steinecke A, Gampe C, and Bolz J (2011) Bidirectional ephrinB3/EphA4 signaling mediates the segregation of MGE- and POA-derived interneurons in the deep and superficial migratory stream. The Journal of Neuroscience, 31:18364-18380 
13. Zimmer G, Menezes S, Bürger S, Weth F, Steinecke A, Bolz J, and Lent R (2010) The role of Chondroitin sulfate/Sema3A interactions during tangential migration of cortical interneurons. Cerebral Cortex, 10:2411-22
14. Rudolph J, Zimmer G, Steinecke A, Barchmann S, and Bolz J (2010) Ephrins guide migrating cortical interneurons in the basal telencephalon. Cell Adhesion and Migration, 4:400-408

* equal contribution