Plateforme NeuroTimone (PFNT)

La PFNT (Plateforme NeuroTimone) est un ensemble cohérent d'outils d'exploration en neurobiologie permettant des investigations aux échelles moléculaires, cellulaires et intégrées.

A la Une

  1. 3 doctorants de l'INP à la FENS 2024

    Sofia (doctorante équipe 7), Charbel (doctorant équipes 3 et 9) et Jehanne (doctorante équipe 5) ont participé et présenté des posters à FENS 2024 à Vienne (Autriche). Ce fut une expérience enrichissante de discuter de leurs travaux avec leurs pairs, d'assister à des présentations sur des recherches novatrices dans nos domaines respectifs, et de déguster des plats typiques autrichiens avec d'autres membres de NeuroMarseille et d’ailleurs. 

  2. New master student in team 1

    Rafael Godoy, recipient of the prestigious Eiffel Excellence Scholarship, recently started a two-month internship in the Neural Plasticity and Degeneration team. Originally from João Pessoa, Brazil, he is currently pursuing a Master's degree in Neurosciences at the Aix-Marseille University.

    During his internship, he will be working on the effects of MT5-MMP on neuroinflammation and intracellular trafficking.

  3. couverture la provence 31 mai 2024
    l'INP à l'honneur dans la Provence

    Dans son édition du vendredi 31 mai 2024, La Provence mettait l'INP à l'honneur dans son dossier sur la maladie d'Alzheimer. Le Pr Mathieu Ceccaldi (Service de Neurologie et Neuropsychologie Adultes & équipe 9) était interrogé sur les nouveaux traitements, pendant que François Devred (équipe 9) et Santiago Rivera (équipe 1) étaient eux interrogés sur les travaux des "six équipes qui bossent à temps plein dans ce "gros" laboratoire français de recherche sur Alzheimer"

  4. New trainee - Team 4

    Carla Djian joined our team for her 1-month M1 internship. Carla is a neuroscience master student at AMU.

    Welcome!

  5. APP at the INP

    The last 2 weeks, several INP teams hosted M1 students for their APP (Apprentissage Par Projet). For many, it was a first experience in a research lab! Each APP is organized around a larger project (Alzheimer's Disease, Myelin, Functional imaging) and students rotate between different labs of NeuroMarseille.

    Thanks to Laurence, Christine (Team 1), Theresa, Fanny (Team 7), Naz and Marine (Team 4) for mentoring all these students!

  6. MEDIM 2024 - retour d'expérience

    Du lundi 15 au vendredi 19 avril 2024 s'est tenue, toujours avec succès, la troisième édition de la formation MedIM (Méthodes d'étude des Interactions Moléculaires) co-organisée par la Plateforme INteractome Timone (PINT) de l’INP, la plateforme de Biologie Structurale de l’AFMB et les plateformes de l’IMM, toutes trois labellisées "Plateformes Technologiques Aix-Marseille".

  7. Ma Terre en 180 Minutes workshop at the annual seminar for DR12 laboratory directors of the CNRS

    Louise (our sustainable development referent) led a Ma Terre en 180 Minutes workshop at the annual seminar for laboratory directors (DU) at DR12 of the CNRS in Saint-Raphaël, on April 18. 

    40 laboratory directors from the Provence and Corsica regions were able to experience the workshop developed by colleagues from the Observatoire des Sciences de l'Univers de Grenoble (OSUG). These directors had to collectively identify the levers of action for a research team in order to reduce their annual greenhouse gas emissions by 50% in a very short space of time.

  8. 5th Scientific Annual Conference - Institut Cancer et Immunologie (ICI)

    On 4 April, Nora Essakhi, Roberta Stacchini and Alexandre Bertucci, PhD students in the GlioME team, presented their poster at the 5th Scientific Annual Conference - Institut Cancer et Immunologie (ICI) on the theme of "CAR T cells, advances in cellular engineering and future challenges in cancer therapy".

    Nora's work on "GD3, a promising therapeutic target for CAR-T cells against glioblastoma stem cells", was recognised by the scientific committee, which awarded her the prize for best poster. Well done Nora!

     

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L'INP en chiffres

  • 126 membres
  • 44 chercheurs
  • 48 chercheurs assistants
  • 12 post-doctorants
  • 11 doctorants

 

3 doctorants de l'INP à la FENS 2024

Sofia (doctorante équipe 7), Charbel (doctorant équipes 3 et 9) et Jehanne (doctorante équipe 5) ont participé et présenté des posters à FENS 2024 à Vienne (Autriche). Ce fut une expérience enrichissante de discuter de leurs travaux avec leurs pairs, d'assister à des présentations sur des recherches novatrices dans nos domaines respectifs, et de déguster des plats typiques autrichiens avec d'autres membres de NeuroMarseille et d’ailleurs. 

Français

New master student in team 1

Rafael Godoy, recipient of the prestigious Eiffel Excellence Scholarship, recently started a two-month internship in the Neural Plasticity and Degeneration team. Originally from João Pessoa, Brazil, he is currently pursuing a Master's degree in Neurosciences at the Aix-Marseille University.

During his internship, he will be working on the effects of MT5-MMP on neuroinflammation and intracellular trafficking.

Indéfini

l'INP à l'honneur dans la Provence

Dans son édition du vendredi 31 mai 2024, La Provence mettait l'INP à l'honneur dans son dossier sur la maladie d'Alzheimer. Le Pr Mathieu Ceccaldi (Service de Neurologie et Neuropsychologie Adultes & équipe 9) était interrogé sur les nouveaux traitements, pendant que François Devred (équipe 9) et Santiago Rivera (équipe 1) étaient eux interrogés sur les travaux des "six équipes qui bossent à temps plein dans ce "gros" laboratoire français de recherche sur Alzheimer"

Indéfini
couverture la provence 31 mai 2024

APP at the INP

The last 2 weeks, several INP teams hosted M1 students for their APP (Apprentissage Par Projet). For many, it was a first experience in a research lab! Each APP is organized around a larger project (Alzheimer's Disease, Myelin, Functional imaging) and students rotate between different labs of NeuroMarseille.

Thanks to Laurence, Christine (Team 1), Theresa, Fanny (Team 7), Naz and Marine (Team 4) for mentoring all these students!

Indéfini

MEDIM 2024 - retour d'expérience

Du lundi 15 au vendredi 19 avril 2024 s'est tenue, toujours avec succès, la troisième édition de la formation MedIM (Méthodes d'étude des Interactions Moléculaires) co-organisée par la Plateforme INteractome Timone (PINT) de l’INP, la plateforme de Biologie Structurale de l’AFMB et les plateformes de l’IMM, toutes trois labellisées "Plateformes Technologiques Aix-Marseille".

Indéfini

Ma Terre en 180 Minutes workshop at the annual seminar for DR12 laboratory directors of the CNRS

Louise (our sustainable development referent) led a Ma Terre en 180 Minutes workshop at the annual seminar for laboratory directors (DU) at DR12 of the CNRS in Saint-Raphaël, on April 18. 

40 laboratory directors from the Provence and Corsica regions were able to experience the workshop developed by colleagues from the Observatoire des Sciences de l'Univers de Grenoble (OSUG). These directors had to collectively identify the levers of action for a research team in order to reduce their annual greenhouse gas emissions by 50% in a very short space of time.

Indéfini

Agenda

13 sep 2024 10:00

Team 1: Guest seminar: Dr. Nicolas Sergeant

 

Nicolas SERGEANT is an Inserm Research Director who, from the natural history of Alzheimer’s disease (AD), the development of cell drug-screening models against AD and Tauopathies, and also thanks to a long-term collaboration with the organic chemistry laboratory of Pr. Patricia Melnyk has co-developed small anti-Alzheimer’s drugs that mitigate the pathophysiology of Alzheimer’s disease. One of these is currently in clinical phase II by a PharmD Company. He is also delighted to identify and validate biomarkers to assess neurodegenerative processes in neurological disorders and develop gene therapy using a molecular decoy strategy.

Seminar title: Bio-orthogonal chemistry as a tool for biological target identification and deciphering the mechanism of action of small anti-Alzheimer drug candidates

 

Abstract:

      Our research has the potential to significantly impact the development of Alzheimer’s disease (AD) modifying drugs. Targeting amyloid deposition and neurofibrillary degeneration, along with neuroinflammation, is a challenging pharmacological strategy. We have synthesized five families of drugs, originally derived from chloroquine or amodiaquine and computer-assisted pharmacophore design, to achieve this goal (Sergeant et al., 2019; Tautou et al., 2021). Among these, novel polyaminobiaryl compounds, including PEL24-199, were produced and shown to repress amyloid production in vitro. In vivo, this water-soluble drug led to the recovery of short and long-term memory in transgenic animal models of both pathological processes of AD. This recovery was associated with a reduced Tau and amyloid pathology and the reduction of astrogliosis and neuroinflammation in both models. The drugs’ target is unknown, and based on the pharmacophore chemical structure, bioorthogonal chemistry was used to covalently couple the drug to the biological target and click-chemistry to isolate, purify, and identify the target of our drugs. This strategy thus enables, based on a phenotyping hit-screening, the identification of potent novel drug-directed development of anti-Alzheimer disease strategies, offering hope for the future of AD treatment.

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