The Institute of NeuroPhysiopathology (INP) is a training and research centre of excellence that combines basic and translational research to study neural cell organisation, function and interaction, the molecular and cellular bases of major brain diseases, and to develop innovative cellular and molecular therapeutic strategies.
The PFNT Facility is a coherent set of exploration tools in neurobiology allowing research at the molecular, cellular and integrated levels.
In collaboration with other teams, the glioME team participated in two new scientific publications:
"Deciphering the heterogeneity of the Lyve1+ perivascular macrophages in the mouse brain": https://www.nature.com/articles/s41467-022-35166-9
"Challenges in glioblastoma research: focus on the tumor microenvironment": https://pubmed.ncbi.nlm.nih.gov/36400694/
Our team is pleased to welcome Mensah Loko for a 6 months Master internship (from November 2022) in Integrative Biology and Physiology: Integrative approach to the functions of life: from gene to pathology. The subject of his internship is the role of Adrenomedullin expressed by glioblastoma-associated endothelial cells in promoting a stable and functional angiogenesis.
We are happy to celebrate the release of 3 first author papers on Myotoxin-3 from a snake venom as a new microtubule targeting agent, on the mechanism of action of Zinc induced aggregation of tau, and a review article on tau as a therapeutic target for cancer, for team 9 three PhD students : Cecilia, Dahbia and Rayane, this month :
Clara Camilla, PhD student, Biology-Health - Oncology speciality, is starting her thesis on the theme: "Evaluation of Longitudinal Genomic Alterations in Diffuse Low Grade Gliomas in Adults".
Emeline Tabouret and Aurélie Tchoghandjian, in collaboration with Thierry Virolle's team at the l'Institut de Biologie Valrose in Nice, are among the two winners to have obtained "Action structurante" funding from the Cancéropôle PACA.
This funding aims to structure the neuro-oncology at the preclinical and translational level in the region (between Marseille and Nice) and will be used to create the PETRA (PrEclinical and TRAnslational Research) platform on these two sites.
Chiara Bastiancich published the last article of her first postdoc on GRAVITY project 🎉
The challenging goal was: delivering to the brain metallic nanoparticles via focused ultrasound-mediated blood-brain barrier (BBB) permeabilization, to heat them using lasers for glioblastoma photothermal therapy! In this paper she shows one of the steps to reach this daunting task.
Géraldine Ferracci (Study Engineer on the PINT platform) participated in the publication entitled "Molecular landscape of BoNT/B bound to a membrane inserted synaptotagmin/ganglioside complex" which appeared on August 25, 2022 in Cellular and Molecular Life Sciences.
Abstract :
Après une période transitoire où il est resté sur le site de la faculté Nord, le spectromètre de masse de l'INP (Thermo Scientific Q-exactive) est arrivé sur le site Timone cet été. Maya Belghazi ayant quitté l'INP pour rejoindre l'IMM, Claude Villard est dorénavant votre seul interlocuteur pour les projets en lien avec cet appareil.
Team 8 has recently obtained a CMA-CGM funding in the framework of the call for projects "Programme d'équipement et de recherche clinique" 2022
The project title is "Program of Precision RAdioTherapy to Improve patient Cancer treatment" and aims to participate in the purchase of a small animal irradiator "SARRP" that will complement the pre-clinical offerings of the PETRA network.
Team 9 represented by José Luis and team 8 represented by Aurélie Tchoghandjian have obtained Amidex Blanc funding for the project: "Bioinspired cytotoxic copper complexes: deciphering their mechanism of action in cancer cells to develop efficient therapeutic agents (CytoCu4Cancer)".
This project is led by a chemist, Olga Iranzo of the Institute of Molecular Sciences of Marseille (iSm2).
Depuis lundi 3 Avril, l'INP participe à une opération inter-laboratoires de quantification de déchets recyclables professionnels (et ménagers) sur le campus Timone.
Pour cela, chaque aile a été aménagée avec des points de collecte et de tri sélectif. Chaque semaine, les différentes catégories seront pesées puis emmenées au recyclage pour valorisation.
Comme chaque année les membres de l'INP participent à la semaine du cerveau. Parmi les actions de cette année on peut citer l'intervention de Cynthia et Charbel deux doctorants de l'équipe 9 qui sont allés rendre visite à l'école primaire du Pharo Catalans
In collaboration with the Holtzman lab., Maud Gratuze, with her colleagues Monica Xiong and Chao Wang, published an article on a project developed during her postdoc in the USA. In this study, entitled "Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy" and recently published in Molecular Neurodegeneration, they reduced ApoE4, the strongest genetic risk factor in Alzheimer’s disease, specifically derived from astrocytes in a mouse model of cerebral amyloid angiopathy.
RESEARCH FIELD(S) AND DISCIPLINES
Neurosciences
Biological sciences
JOB /OFFER DESCRIPTION
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