NeuroCyto: the neuronal cytoskeleton in health and disease

The last 2 weeks, several INP teams hosted M1 students for their APP (Apprentissage Par Projet). For many, it was a first experience in a research lab! Each APP is organized around a larger project (Alzheimer's Disease, Myelin, Functional imaging) and students rotate between different labs of NeuroMarseille.

Thanks to Laurence, Christine (Team 1), Theresa, Fanny (Team 7), Naz and Marine (Team 4) for mentoring all these students!

The latest collaboration from the NeuroCyto team was just published in the Journal of Cell Science, and asks a simple question: how do microtubule and actin fight or cooperate with each other? The CytoMorpho lab of Manuel Théry and Laurent Blanchoin in Paris and Grenoble used complex in-vitro reconstitution to show how dense actin networks can stop microtubule growth.

Super-resolution microscopy is super-nice, but it can also be super-expensive or super-complicated. But now it's super-simple to get nanoscale details of your favorite cells with any kind of microscope, thanks to the enhanced version of the SRRF algorithm just published in Nature Methods!

The NeuroCyto team published their latest work in the Journal of Cell Biology (article is available here), where they reveal the presence of distinct actin nanostructures within presynapses. The article is featured in the October issue of the journal, and made it to the cover that shows a nice picture of a neuron endogenously tagged for actin using CRISPR/Cas9.

The NeuroCyto team published a new article in Cell Reports Methods. This is the work of PhD student Karoline Friedl in collaboration with the Abbelight company: we thoroughly characterized two different modalities of simultaneous multicolor Single Molecule Localization Microscopy using a two-camera module. The article can be found here (open access).

The NeuroCyto team has a new publication out! Published on November 5th in Science, this article elucidates how adenosine A2A receptors drive removal of inhibitory synapses depending on their activity. This is a fruitful collaboration with the labs of Sabine Lévi at Institut du Fer à Moulin (IFM) in Paris and Christophe Bernard at Institut de Neuroscience des Systèmes (INS) in Marseille.

The NeuroCyto team has a new publication out! Published on Sep. 15 in Neuron, this article reveals how clathrin is slowly transported along axons by forming transport packets that are then docked at presynapses where they can dynamically supply clathrin for synaptic function. This is another episode of the long-standing collaboration between the NeuroCyto team and the lab of Subhojit Roy at UCSD. Read the article here: https://doi.org/10.1016/j.neuron.2021.08.016

Each week-end the local newspaper La Marseillaise puts the spotligh on a scientific topic and on a team of research in a scientific page called "Provence Terre de Science". After the page about Alzheimer disease last year (see here), INP research has been highligthed with the interview of Jean Marc Sabatier (Cytoskeleton and Neurophysiopathology team) for his work on venoms, and then Christophe Letterier (NeuroCyto team) for his work on sup

The NeuroCyto team has two new articles just out in Nature Communications! Click for more details >>

The NeuroCyto team was awarded an “Équipe” grant from the Fondation pour la Recherche Médicale. With more than 400,000 euros over three years, it will allow the team to investigate the organization and role of actin at presynapses using advanced micromanipulation and cutting edge super-resolution microscopy.