NeuroTimone Facility (PFNT)

The PFNT Facility is a coherent set of exploration tools in neurobiology allowing research at the molecular, cellular and integrated levels.


  1. GlioME team in collaboration with INT (Institute of Neurosciences Timone) published a new study in Journal of Neuroinflammation on the effect of Bevacizumab on glioblastoma-bearing mice, using 2-photon imaging

    Our data show that VEGF blockade leads to an increased recruitment of monocytes and to an adjustment of dendritic cell subsets’ profiles, differing in their ability to induce an adaptive immune response. Altogether, they provide important new insights into the effects of Bevacizumab at the cellular level and into the spatio-temporal evolution of intra-tumoral innate immune cell densities.

  2. Pr Hervé Kovacic joins the editorial board of Antioxidant Redox Signaling
  3. Marseille - Cassis 2019
  4. Anne-Marie François Bellan
    Listening to our molecular clocks

    During the NeuroStories event, held on Monday October 7 at the Faculty of Medicine, Anne-Marie François Bellan gave a remarkable stand up on how our body vibrates to the rhythm of internal chronometers called circadian clocks. She also explained how the molecular clock uses small corpuscles and cell space to make our genes rhythm.

    Click on the news to  see the video of her brilliant speech.





  5. Prof. D. Figarella-Branger, who belongs to the cIMPACT-NOW Working Committee, attended to the last meeting of the consortium in Utrecht (16-17 september).

    The cIMPACT-NOW Working Committee is the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy. cIMPACT-NOW  was created in late 2016 —following publication of the 2016 Updated 4th Edition of the World Health Organization (WHO) Classification of Tumours of the Central Nervous System— to provide a forum to evaluate and recommend proposed changes to future CNS tumor classifications.

  6. Three members of INP presented their work on Glioma during the 14th EANO annual meeting held in Lyon (19 - 22 September, 2019)

    During the 14th EANO annual meeting 3 members of INP team #8 presented their work on Glioma in a plenary conference «CDKN2A homozygous deletion is a strong adverse prognosis factor in diffuse malignant IDHmutant gliomas» Dominique Figarella Branger, a short talk «Plasmatic differential scanning fluorimetry profiles discriminate glioma patients from healthy controls» Emeline Tabouret and two posters «P11.06: Non epigenetic effect of vorinostat in glioblastoma cells» and «EB1-dependant long survival of glioblastoma cancer stem-like cells tumor

  7. Nadia Merad Coliac and Maxime Bonnet joined the NOSE team

    Nadia Merad Coliac, plastic designer, joined the NOSE (Nasal Olfactory Stemness and Epigenesis) team, as an Associate researcher. At the crossroads of several disciplines, she develops an experimental work of art and science, in the field of bioluminescence. She is considering a therapeutic application in patients with autism spectrum disorders (ASD). Recently, Nadia published Lumière vivante - Théorie et pratique de la bioluminescence (Living light - theory and use of bioluminescence) - L’Harmattan eds.

  8. New publication from the GlioME Team (INP team 8) in Cancers pointing at A2B5 as an attractive therapeutic target for glioblastomas.


INP in numbers

  • 126 members
  • 44 researchers
  • 48 research assistants
  • 12 post-docs
  • 11 PhD


MedIM 2020 : First inter-platform Interactome workshop

INP platform PINT together with AFMB and IMM are glad to announce their first inter-platform interactome workshop entitled "Methods to study Molecular Interactions (Biomedical applications)" that will take place from monday december 7th to friday 11th 2020. 

Looking to confirm the interaction between a drug and its target?
Wanting to characterize the interaction between a receptor and its ligand?


New publication of the GlioME team.

In this paper we reported two uncommon adult cases of Diffuse Leptomeningeal Glioneuronal Tumors (DLGNTs) diagnosed after DNA-methylation profiling. This study enlarges the clinical and molecular spectrum of DLGNTs which encompass a wide spectrum of tumors that has yet to be fully clarified, and suggest that this terminology appears unsuitable in some cases.


Nanotemper Technologies 1st Virtual Symposium 

Romain La Rocca, third year PhD student in INP team 9 (Cytoskeleton and Neurophysiopathology), will present a part of his thesis work during the 1st NanoTemper Virtual Symposium on June 30th from 9 to 12h30. NanoTemper annual seminars bring together the researchers using NanoTemper instruments, or eager to discover new technologies and in different fields of research. During this event, Romain will show how to use the nanoDSF technology to study the quaternary structure of tubulin. 


PINT new acquisition: Tycho™ NT.6 for instant protein quality control

The Platform INteractome Timone - PINT is pleased to announce the arrival of the Tycho™ NT.6, the new nanoDSF instrument by Nanotemper. The Tycho is designed to characterize the quality of any protein within minutes, using only 10 µL of sample. This fast analysis is critical for choosing the batches, buffers, or conditions by comparing the relative stability of each sample along every step of an experiment, thus allowing an efficient assay and purification workflow development.


PRA - Plan de Reprise des Activités - INP / VECT-Horus

Après près de 2 mois de fermeture du laboratoire, un plan de reprise des activité vient d'être mis en place pour une sortie de confinement progressive et évolutive en toute sécurité. La reprise de nos activités au laboratoire va se concrétiser à partir du 12/05 mais seulement de manière partielle. Il s’agit d’une part de respecter les recommandations de nos tutelles, d’autre part de travailler dans les meilleures conditions possibles sur le plan de notre sécurité qui reste notre première priorité. 

Réouverture du Campus Timone

CNRS - Amélioration de la Qualité de Vie au Travail

Le projet « 80 plantes pour les 80 ans du CNRS » avance : la liste des plantes à commander a été établie. Les commandes seront passées dès que les jardineries pourront vendre les plantes ornementales. En effet, l’Etat a autorisé, en avril, la réouverture des jardineries et pépinières, pour vendre des graines, bulbes, plantes aromatiques et plants à vocation alimentaire. Les plantes décoratives ne sont pas remises à la vente, pour de meilleures conditions sanitaires d’achat.


l'INP se mobilise contre le COVID-19

Dans le cadre des actions de la lutte contre le COVID-19, conformement aux dispositions prises par Aix Marseille Université en concertation étroite avec le CNRS, CEA, INRAE, INRIA et INSERM, l'INP comme la plupart des laboratoires de recherche a fait don d'une grande partie de ses kits et consommables pouvant servir à prévenir, dépister et soigner dans le cadre de la lutte contre le COVID-19. Un grand merci à toutes celles et tous ceux qui ont participé au recensement et à la collecte de ces masques, gants, reactifs, etc ...

collecte consommables