New publication in Frontiers in Oncology
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The Institute of NeuroPhysiopathology (INP) is a training and research centre of excellence that combines basic and translational research to study neural cell organisation, function and interaction, the molecular and cellular bases of major brain diseases, and to develop innovative cellular and molecular therapeutic strategies.
Teams
NeuroTimone Facility (PFNT)
The PFNT Facility is a coherent set of exploration tools in neurobiology allowing research at the molecular, cellular and integrated levels.
News
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Michel KHRESTCHATISKY invited to the third edition of “Translational neuroscience Day: challenges and opportunities” co-organized by DHUNE and NeurATRISMichel KHRESTCHATISKY, Director of the UMR7051 Institute of Neurophysiopathology at Aix-Marseille University / CNRS and co-founder of VECT-HORUS was invited at the third edition of “Translational neuroscience Day: challenges and opportunities” co-organized by DHUNE and NeurATRIS and hosted by BioFIT on December 10, 2019 (https://www.biofit-event.com/translational-neuroscience).
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Maeva MONTALEYTANG and Noé DUMAS from the GlioME team presented their research on nanoparticles at the SFNano C'Nano congressMaeva and Noé presented their poster at the SFNano C'Nano conference entitled "Preclinical evaluation of a paclitaxel nanoprodrug for glioblastoma therapy".
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Un nouvel arrivant dans l'équipe 5L'équipe 5 a le plaisir d'accueillir en stage du 1er décembre 2019 au 31 mars 2020, Théo Loignon étudiant à l'école d'ingénieur de Bordeaux ei.cesi. Théo travaillera avec Jean-Philippe Dales sur l'imagerie chimique du tissu nerveux au cours de la neuroinflammation.
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New publication for the Neuro-inflammation and Multiple Sclerosis team (INP team 5) in Cytokine about the immunomonitoring of infliximab biotherapiesIn this paper, Daniel Bertin evaluated the immunological follow-up of patients suffering from chronic inflammatory diseases and receiving anti-TNF biotherapy. Three commercial ELISA assays for monitoring soluble through levels of infliximab and anti-infliximab antibodies in serum showed a good global correlation of results. However, some quantitative discrepancies could change clinical decision. As a consequence, Daniel Bertin recommended to keep the same kit to perform a longitudinal follow-up of patients.
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Aurélie Tchoghandjian-Auphan, CRCN CNRS from the GlioME team, was recently granted by ARC fondation for her project "Effects of Smac mimetics treatment on glioblastomas immune response" .Aurélie Tchoghandjian-Auphan, CRCN CNRS from the GlioME team, in the Insitute of NeuroPhysiopathology, UMR CNRS 7051, was recently granted by ARC fondation for her project "Effects of Smac mimetics treatment on glioblastomas immune response".
Subsequently she was interviewed by :
- France 3 (JT 19/20 PACA diffusion du 15/11: 7'09 à 9'45) ;
- Provence Azur (18/11/2019) ;
- 20 Minutes Marseille (18/11/2019)
- La Provence -
DESU « Exploration et traitement des maladies auto-immunes »Vous êtes médecin, pharmacien, interne en médecine ou biologie médicale et intéressé par les maladies auto-immunes et inflammatoires chroniques ?
Dépêchez-vous, il ne reste que quelques places pour la session 2019-2020 du DESU « Exploration et traitement des maladies auto-immunes » (coordination : Dr Sophie Desplat-Jégo – Faculté de Médecine de Marseille). Inscriptions jusqu'au 30 novembre 2019.
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GlioME team in collaboration with INT (Institute of Neurosciences Timone) published a new study in Journal of Neuroinflammation on the effect of Bevacizumab on glioblastoma-bearing mice, using 2-photon imagingOur data show that VEGF blockade leads to an increased recruitment of monocytes and to an adjustment of dendritic cell subsets’ profiles, differing in their ability to induce an adaptive immune response. Altogether, they provide important new insights into the effects of Bevacizumab at the cellular level and into the spatio-temporal evolution of intra-tumoral innate immune cell densities.
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Pr Hervé Kovacic joins the editorial board of Antioxidant Redox SignalingThe leading peer-reviewed journal dedicated to understanding of the vital impact of oxygen and oxidation-reduction (redox) processes on human health and disease, exploring key issues in genetic, pharmaceutical, and nutritional redox-based therapeutics.
For more information, head to the ARS website.
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INP in numbers
- 126 members
- 44 researchers
- 48 research assistants
- 12 post-docs
- 11 PhD
The NeuroCyto team receives two ANR grants in 2020
The NeuroCyto team led by Christophe Leterrier was awarded two collaborative ANR grants in the 2020 call. The first project, “How actin/spectrin scaffold shapes axonal physiology” (ASHA), is coordinated by C. Leterrier in collaboration with the teams of Stéphane Vassilopoulos (Institut de Myologie, Paris) and Emmanuel Nivet at INP.
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Laurie Arnaud (Team6) on the Neurobinar #3 (NeuroMarseille) !
Laurie Arnaud will be presenting on the Neurobinar #3 on December 17 at 4 pm on Zoom.
For this third edition, NeuroMarseille is pleased to welcome Christelle Baunez (INT), Laurie Arnaud (INP) and Nada El Mahmoudi (LNSC/LNC). Laurie Arnaud and Nada El Mahmoudi will introduce their respective theses in a cross presentation. After a question and answer session, Christelle Baunez (INT) will explain her research on the role of basal ganglia (GB) in motivation and reward processes.
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Dr. Emeline Tabouret (GlioME team) in collaboration with Dr. Rafael Arguello (CIML Institute) published a new paper in Cell metabolism journal
This paper entitled "SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution" presents a new technique to study the metabolic responses in multiple cell types in parallel by flow cytometry.
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A successful partnership between the APHM Pathology department / the GlioME team and ID-Solutions industrial society.
A successful partnership between the APHM Pathology department / the GlioME team and ID-Solutions industrial society (https://www.id-solutions.fr/fr/), has led to the developement of ready-to-use kits for the detection and quantification by digital PCR of key genetic alterations of brain tumours, specifically gliomas.
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Poste pourvu : The Institute of NeuroPhysiopathology (INP) welcomes tenured researchers/lecturers, and junior researchers to lead or strengthen its research programmes
The Institute of NeuroPhysiopathology (INP) is a new laboratory of the CNRS/Aix-Marseille University created in 2018 that combines fundamental and translational research in a stimulating and friendly working environment (https://inp.univ-amu.fr). The INP is located on the Health Sciences Campus of La Timone, which is home to other leading neuroscience laboratories, bringing together more than 400 people covering a wide range of topics.
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Emeline TABOURET and Chiara BASTIANCICH recieved a grant of 30 000€ each
Dr. Emeline Tabouret (MCU-PH) and Dr. Chiara Bastiancich (Post-doc) from the GlioME team received the "Emergence" grant co-funded by the Canceropôle PACA and the Association pour la Recherche sur les Tumeurs Cérébrales (ARTC-Sud).
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Le label « Plateforme Technologique Aix-Marseille » de la PlateForme NeuroTimone PFNT a été renouvelé
Le label « Plateforme Technologique Aix-Marseille » de la PlateForme NeuroTimone PFNT a été renouvelé pour une nouvelle période de 3 ans par AMU, l’Inserm et le CNRS. Pour mémoire rappelons que la PFNT est constituée des plateformes NCIS, PINT et SCeNT de l’INP et de INPHIM de l’INT. La PFNT offre un éventail de prestations technologiques en neurobiologie au niveau local pour les équipes de recherche et start up de Marseille mais aussi au niveau régional et national.
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Performance théatralisée en hommage à Raphaël Dubois
Une production théâtrale et une performance artistique qui auront lieu le 8 décembre à 19h30 (suite au confinement, la performance a été reportée pour la prochaine saison). Cette représentation, produite par Nadia Merad Coliac, est une œuvre inédite. Elle aura lieu à Paris au théatre Reine Blanche, scène des arts et des sciences. C'est la première fois qu'elle travaille pour un théâtre.
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PINT new acquisitions: Biacore T200 & AKTA pure
The Platform INteractome Timone - PINT is pleased to announce the arrival of a brand new Surface Plasmon Resonance Biacore T200 (Cytiva, ex GE Healthcare) designed to follow in real time interactions between free-labeled biomolecules from ions to viruses. The use of real-time measurement allows to provide association (kon) and dissociation (koff) rate constant of the interaction and to deduce its affinity (KD).
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