Semaine du Cerveau : Causerie de Michel Khrestchatisky (INP) sur le Campus de la Timone
En raison des mesures prises pour freiner l'épidémie COVID-19, cette causerie est bien évidemment annulée ...
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The Institute of NeuroPhysiopathology (INP) is a training and research centre of excellence that combines basic and translational research to study neural cell organisation, function and interaction, the molecular and cellular bases of major brain diseases, and to develop innovative cellular and molecular therapeutic strategies.
Teams
NeuroTimone Facility (PFNT)
The PFNT Facility is a coherent set of exploration tools in neurobiology allowing research at the molecular, cellular and integrated levels.
News
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INP students presented their research work at the 14th International Conference on Alzheimer's and Parkinson's Diseases (ADPD)On the 26-31st March, the 14th International Conference on Alzheimer's and Parkinson's Diseases (ADPD) and related neurological disorders was held in Lisbon, Portugal. This year, almost the entire team 1 and team 6 went to this major event and our students: Laurie Arnaud, Laura García González and Dominika Pilat took the opportunity to present their work on a poster.
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New publication from the NeuroCyto team in Nature Communications: Perform advanced microscopy experiments thanks to NanoJ-FluidicsThe LEGO Pumpy (or more officially NanoJ-Fluidics) paper is out in Nature Communications! A joint venture between the INP NeuroCyto team and the Henriques lab, this article (previously available as a preprint on bioRxiv) details how to build a fully open-source multi-channel syringe pumps with LEGO and Arduino.
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New preprint from the NeuroCyto team: tips and tricks for super-resolution microscopyWe have a new preprint out! Want to do good super-resolution images? We have put together all our single molecule localization microscopy (SMLM) tips and tricks. This is a methods paper that describes our SMLM workflow, using benchmark samples such as microtubules and clathrin-coated pits.
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New publication from the NeuroCyto team in the Journal of Cell Biology: Slow axonal transport of actin via hotspots and trailsOur latest work (previously on bioRxiv) is now published in the Journal of Cell Biology. We collaborated with the Roy lab (UW Madison, USA) and the Jung lab (Ohio University, USA) to reveal a new mechanism of slow axonal transport, based on our previous discovery of actin hotspots and trails.
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Christophe from the NeuroCyto team delivers plenary lecture at MiFoBio 2018Christophe was lucky to spend a whole week at the “Microscopie Fonctionnelle en Biologie” aka MiFoBio workshop. Lots of fun attending dozens of cutting-edge workshops, trying super-resolution microscopes, discussing, DJing (!), and presenting the latest work from the lab.
More on Twitter: #MiFoBio2018
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The GlioME team has popularized a scientific article to make its research accessible to the general public.The popularization of science is one of the missions of academic research. This article authored by Aurélie Soubéran is intended for children aged 12-13 years and more broadly for the general public, and focuses on a preclinical study on glioblastoma model.
To access it, please download the pdf version.
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F. Devred presented PINT / INP work on a non-conventional use of nanoDSF at the ARBRE MOBIEU meetingFrançois Devred has presented his PINT/INP work on non-conventional use of nanoDSF in less than 180 seconds at the 3rd Arbre Mobieu plenary meeting in Zagreb.
See his flash presentation here and the meeting program on Arbre Mobieu website.
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Vect-Horus and RadioMedix announce signing of a Letter of Intent to co-develop a radio-theranostic agent for GlioblastomaThis partnership will marry the expertise of Vect-Horus in targeting tumors with its technology VECTrans® and the know-how of RadioMedix in developing and conducting pre-clinical evaluation and clinical trials with radiopharmaceuticals.
For more information, please follow this link or download the pdf version.
Pages
INP in numbers
- 126 members
- 44 researchers
- 48 research assistants
- 12 post-docs
- 11 PhD
Romain La Rocca won best poster prize at ARBRE-MOBIEU 4th plenary meeting in Prague
Romain La Rocca, third year PhD student in INP team 9 (Cytoskeleton and Neurophysiopathology), recently won the the best poster prize at the 4th ARBRE-MOBIEU pleanry meeting in Prague on February 24, 25 and 26.
English
The GlioME team published a new article in Oncotarget journal: EB1-dependent long survival of glioblastoma-grafted mice with the oral tubulin-binder BAL101553 is associated with inhibition of tumor angiogenesis.
Our study shows that a treatment with the microtubule-destabilizing agent BAL101553 counteracts tumor angiogenesis by acting on glioblastoma stem-like cells, in an EB1-dependent manner. This work provides new insights into the therapeutic targeting of cancer stem-like cells.
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CNRS - Amélioration de la Qualité de Vie au Travail
Au printemps 2019, le CNRS a lancé un appel à projets, pour la 3e année consécutive, dans l’optique de l’amélioration de la Qualité de Vie au Travail (QVT)...
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Philipp Tsvetkov received a 29 000 € grant from the GEFLUC
- The Emergence project entitled “New high throughput screening method for anticancer agents” carried out by Philipp Tsvetkov (first from the right) was selected by the Canceropole PACA to be funded by the GEFLUC (groupement des entreprises françaises dans la lutte contre le cancer).
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Aurélie Tchoghandjian, jeune chercheur dans l'équipe GlioME a brillament obtenu son Habilitation à Diriger les Recherches (HDR)
Aurélie Tchoghandjian a soutenu son Habilitation à Diriger les Recherches (HDR) devant un jury d'experts composé de cliniciens : Pr. Nicolas André, Pr. François Ducray, Pr. Dominique Figarella-Branger; et de chercheurs : Dr. Emmanuelle Huillard et Dr. Monique Dontenwill.
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New publication from Sylvie Carmona (Neuro-inflammation and Multiple Sclerosis team - INP team 5)
As part of her PhD, Sylvie Carmona investigated the beneficial effects of NV669, an aminosterol derived from squalamine on human pancreatic and hepatic cancer models. In vitro results exposed in this paper showed that NV669 inhibited the proliferation of cancer cells, induced cell cycle arrest and subsequent apoptosis. Moreover, NV669 inhibited PTP1B activity and impacted adhesion molecules expression. This suggests that NV669 by inhibiting PTP1B would affect cell contacts and would induce apoptosis.
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L'équipe NeuroCyto dans La Provence
Les travaux récents de l'équipe NeuroCyto pour dévoiler l'architecture des des axones font l'objet d'un article dans l'édition du vendredi 17 Janvier de La Provence.
Voir l'article de La Provence dans son intégralité ici ou ci-dessous.
Plus d'information dans l'article scientifique publié recemment dans la revue Nature Communications :
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Deux nouveaux arrivants dans l'équipe GlioME
L'équipe 8 (GlioME) a le plaisir d'accueillir deux étudiants en Master 2, Anaïs Arathni étudiante en Master Biologie Santé et Emmanuel Snacel-Fazy étudiant en Master Neurosciences. Anaïs travaillera avec Aurélie Tchoghandjian sur la caractérisation des cellules immunitaires recrutées sur le site tumoral suite au traitement par mimétiques de Smac. Emmanuel travaillera avec Chiara Bastiancich sur le microenvironnement de la résection tumorale du glioblastome.
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A commentary from Christophe Leterrier in the Journal of Cell Biology
Christophe Leterrier, leader of the NeuroCyto ATIP team, wrote a Spotlight in the Journal of Cell Biology highlighting a nice recent paper from the group of Pei-Lin Cheng in Taiwan. In this article, Lee et al. showed how degradation of the chloride transporter NKCC1 by proteasomes anchored at the AIS have a key role in lowering the intracellular chloride concentration, leading to the perinatal reversal of GABA effect from excitatory to inhibitory.
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