The Institute of NeuroPhysiopathology (INP) is a training and research centre of excellence that combines basic and translational research to study neural cell organisation, function and interaction, the molecular and cellular bases of major brain diseases, and to develop innovative cellular and molecular therapeutic strategies.
The PFNT Facility is a coherent set of exploration tools in neurobiology allowing research at the molecular, cellular and integrated levels.
In a large cohort of 911 high-grade IDH-mutant gliomas from the French national POLA network, we investigated the prognostic value of the CDKN2A gene homozygous deletion as well as WHO grading criteria (mitoses, microvascular proliferation, and necrosis).
We showed that:
- CDKN2A homozygous deletion characterizes diffuse malignant IDH-mutant gliomas with worst outcome.
- Microvascular proliferation stratifies IDH-mutant gliomas lacking CDKN2A homozygous deletion.
On thursday december the 12th, most of INP and Vect-Horus members got together and spent a day in the Black Stone pub, Marseille, to celebrate the fact that nearly two years after its creation, the Institute of NeuroPhysiopathology is finally located on Tmone Campus.
Michel KHRESTCHATISKY, Director of the UMR7051 Institute of Neurophysiopathology at Aix-Marseille University / CNRS and co-founder of VECT-HORUS was invited at the third edition of “Translational neuroscience Day: challenges and opportunities” co-organized by DHUNE and NeurATRIS and hosted by BioFIT on December 10, 2019 (https://www.biofit-event.com/translational-neuroscience).
Maeva and Noé presented their poster at the SFNano C'Nano conference entitled "Preclinical evaluation of a paclitaxel nanoprodrug for glioblastoma therapy".
L'équipe 5 a le plaisir d'accueillir en stage du 1er décembre 2019 au 31 mars 2020, Théo Loignon étudiant à l'école d'ingénieur de Bordeaux ei.cesi. Théo travaillera avec Jean-Philippe Dales sur l'imagerie chimique du tissu nerveux au cours de la neuroinflammation.
In this paper, Daniel Bertin evaluated the immunological follow-up of patients suffering from chronic inflammatory diseases and receiving anti-TNF biotherapy. Three commercial ELISA assays for monitoring soluble through levels of infliximab and anti-infliximab antibodies in serum showed a good global correlation of results. However, some quantitative discrepancies could change clinical decision. As a consequence, Daniel Bertin recommended to keep the same kit to perform a longitudinal follow-up of patients.
Aurélie Tchoghandjian-Auphan, CRCN CNRS from the GlioME team, in the Insitute of NeuroPhysiopathology, UMR CNRS 7051, was recently granted by ARC fondation for her project "Effects of Smac mimetics treatment on glioblastomas immune response".
Subsequently she was interviewed by :
- France 3 (JT 19/20 PACA diffusion du 15/11: 7'09 à 9'45) ;
- Provence Azur (18/11/2019) ;
- 20 Minutes Marseille (18/11/2019)
- La Provence
Vous êtes médecin, pharmacien, interne en médecine ou biologie médicale et intéressé par les maladies auto-immunes et inflammatoires chroniques ?
Dépêchez-vous, il ne reste que quelques places pour la session 2019-2020 du DESU « Exploration et traitement des maladies auto-immunes » (coordination : Dr Sophie Desplat-Jégo – Faculté de Médecine de Marseille). Inscriptions jusqu'au 30 novembre 2019.
This paper entitled "SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution" presents a new technique to study the metabolic responses in multiple cell types in parallel by flow cytometry.
A successful partnership between the APHM Pathology department / the GlioME team and ID-Solutions industrial society (https://www.id-solutions.fr/fr/), has led to the developement of ready-to-use kits for the detection and quantification by digital PCR of key genetic alterations of brain tumours, specifically gliomas.
The Institute of NeuroPhysiopathology (INP) is a new laboratory of the CNRS/Aix-Marseille University created in 2018 that combines fundamental and translational research in a stimulating and friendly working environment (https://inp.univ-amu.fr). The INP is located on the Health Sciences Campus of La Timone, which is home to other leading neuroscience laboratories, bringing together more than 400 people covering a wide range of topics.
Dr. Emeline Tabouret (MCU-PH) and Dr. Chiara Bastiancich (Post-doc) from the GlioME team received the "Emergence" grant co-funded by the Canceropôle PACA and the Association pour la Recherche sur les Tumeurs Cérébrales (ARTC-Sud).
Le label « Plateforme Technologique Aix-Marseille » de la PlateForme NeuroTimone PFNT a été renouvelé pour une nouvelle période de 3 ans par AMU, l’Inserm et le CNRS. Pour mémoire rappelons que la PFNT est constituée des plateformes NCIS, PINT et SCeNT de l’INP et de INPHIM de l’INT. La PFNT offre un éventail de prestations technologiques en neurobiologie au niveau local pour les équipes de recherche et start up de Marseille mais aussi au niveau régional et national.
Une production théâtrale et une performance artistique qui auront lieu le 8 décembre à 19h30 (suite au confinement, la performance a été reportée pour la prochaine saison). Cette représentation, produite par Nadia Merad Coliac, est une œuvre inédite. Elle aura lieu à Paris au théatre Reine Blanche, scène des arts et des sciences. C'est la première fois qu'elle travaille pour un théâtre.
The Platform INteractome Timone - PINT is pleased to announce the arrival of a brand new Surface Plasmon Resonance Biacore T200 (Cytiva, ex GE Healthcare) designed to follow in real time interactions between free-labeled biomolecules from ions to viruses. The use of real-time measurement allows to provide association (kon) and dissociation (koff) rate constant of the interaction and to deduce its affinity (KD).
In this review, we focused on the most widely used 3D human glioblastoma models: spheroids, tumorospheres, organotypic slices, explants, tumoroids and glioblastoma-derived from cerebral organoids. We discuss their history, development and especially their usefulness.
We are very excited to announce that our project "Artificial Intelligence for Onco-Plasma" carried out by Remi Eyraud from QARMA team of LIS in collaboration with team 8, team 9, team 10, and
INP platform PINT together with AFMB and IMM are glad to announce their first inter-platform interactome workshop entitled "Methods to study Molecular Interactions (Biomedical applications)" that will take place from monday december 7th to friday 11th 2020.
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