The Institute of NeuroPhysiopathology (INP) is a training and research centre of excellence that combines basic and translational research to study neural cell organisation, function and interaction, the molecular and cellular bases of major brain diseases, and to develop innovative cellular and molecular therapeutic strategies.
The PFNT Facility is a coherent set of exploration tools in neurobiology allowing research at the molecular, cellular and integrated levels.
Christophe Leterrier from the NeuroCyto team just published a study in collaboration with the Cytomorpho lab - Manuel Théry & Laurent Blanchoin, CEA Paris/Grenoble. Entitled “Self-repair protects microtubules from destruction by molecular motors”, this work demonstrates how motor proteins kinesins and dynein can damage microtubule while walking on them, triggering repair by incorporation of new tubulin monomers inside the microtubule lattice. It was published on Jan.
Dominika Pilat will be presenting on the Neurobinar #4 on January 21 at 4 pm on Zoom.
For this fourth edition, NeuroMarseille is pleased to welcome Cédric Maurange (IBDM), Dominika Pilat (INP) and Borloz Émilie (MMG). Dominika Pilat and Borloz Émilie will introduce their respective theses in a cross presentation. After a question session, Cédric Maurange (IBDM) will explain his research on genetic programmes modifying the properties of neural stem cells during development.
When you say New Year, you say new resolutions!
Increasingly present at the heart of debates and minds, ecology is part of our daily lives and it is our duty to do everything we can to reduce our ecological footprint. The INP has decided to be mobilized for ecology, at its own level.
To begin with, we have set up a plastic bottle collection system to recycle our bottles in a short circuit. This is done via the collection system proposed by the company Yoyo, which guarantees delivery to the nearest recycling plant for 100% recycling! We have three collection points on our premises (salle de convivialité R+3, R+1 et R+2 vert).
Christophe Leterrier, leader of the NeuroCyto team, just published a special review for the 40th anniversary issue of the Journal of Neuroscience. Entitled “A Pictorial History of the Neuronal Cytoskeleton”, it is a journey through the history of the neuronal cytoskeleton in pictures.
A few weeks ago, the Vaincre Alzheimer Foundation came to visit the Institute of NeuroPhysiopathology and made a short documentary on the team Neural Plasticity and Degeneration (Team 1), led by Santiago Rivera who was recently funded by the Foundation. It was an opportunity for him to thank Vaincre Alzheimer and the donors and talk about the importance of MT5-MMP, a protease that contributes to the pathophysiological mechanisms of Alzheimer’s disease and may become a potential new target.
Dans la semaine du lundi 07 décembre au vendredi 11 décembre s'est tenue avec succès la première édition de l'atelier MedIM (Methodes d'étude des Interactions Moléculaires) co-organisé par la Plateforme INteractome Timone (PINT) de l’INP, la plateforme de Biologie Structurale de l’AFMB et les plateformes de l’IMM, toutes trois labellisées "Plateformes Technologiques du site d'Aix-Marseille".
The NeuroCyto team led by Christophe Leterrier was awarded two collaborative ANR grants in the 2020 call. The first project, “How actin/spectrin scaffold shapes axonal physiology” (ASHA), is coordinated by C. Leterrier in collaboration with the teams of Stéphane Vassilopoulos (Institut de Myologie, Paris) and Emmanuel Nivet at INP.
Plusieurs chercheurs de la communauté marseillaise des neurosciences, notamment l’équipe d’Agnès Trébuchon, mènent des recherches sur les fondamentaux et les effets thérapeutiques de la transe cognitive auto-induite. Tout comme l’hypnose ou la méditation, il s’agit d’un état modifié de conscience, induit par la seule volonté de chacun.
Neural Plasticity and Degeneration team has recently welcomed Shweta SONAWANE.
Shweta is from Mumbai (India) she did her Ph.D. at the Biochemical sciences division of CSIR - National Chemical Laboratory in Pune (India).
Her doctoral research was largely focused on Tau pathology in Alzheimer’s disease studying in particular the effect of glycated and phosphorylated Tau on cytoskeleton integrity as well as aggregation propensity in order to find small molecules that could attenuate Tau aggregation and prevent its glycation.
The NeuroCyto team has a new publication out! Published on November 5th in Science, this article elucidates how adenosine A2A receptors drive removal of inhibitory synapses depending on their activity. This is a fruitful collaboration with the labs of Sabine Lévi at Institut du Fer à Moulin (IFM) in Paris and Christophe Bernard at Institut de Neuroscience des Systèmes (INS) in Marseille.
The NeuroCyto team has a new publication out! Published on Sep. 15 in Neuron, this article reveals how clathrin is slowly transported along axons by forming transport packets that are then docked at presynapses where they can dynamically supply clathrin for synaptic function. This is another episode of the long-standing collaboration between the NeuroCyto team and the lab of Subhojit Roy at UCSD. Read the article here: https://doi.org/10.1016/j.neuron.2021.08.016
L’institut de NeuroPhysiopathologie (INP) CNRS UMR_7051 est un centre d’excellence de formation et de recherche au sein de Aix-Marseille Université (site Timone) qui combine la recherche fondamentale et translationnelle pour étudier l’organisation, la fonction et l’interaction des cellules neuronales, ainsi que les bases moléculaires et cellulaires des principales maladies du cerveau.
La force de l’INP
Développer des stratégies thérapeutiques cellulaires et moléculaires innovantes.
Rejoignez-nous !
Nadia Coliac a été l’auteure, metteuse en scène et scénographe d’une expérience théâtrale bioluminescente qui a eu lieu le 19 octobre dernier à Paris sur la scène des arts et des sciences du théâtre de la Reine Blanche. Une expérience grandeur nature d'éclairer tout un théâtre uniquement avec la lumière vivante qui a captivé le public, ce fut un moment magique !
PINT platform recently acquired the NT.Robotic Autosampler that complemented the existing Prometheus NT.Plex nanoDSF instrument which is already equipped with aggregation detection optics to get complete stability characterization.
Romain La Rocca, former member of INP team 9, shared the stage of EuroTau meeting in Lille's Grand Palais with Illana Gozes (Israel), Cláudio M. Gomes (Portugal), Amandine Grimm (Switzerland), Yann Fichou (France), Marina Rierola (Germany), Laura Vallés Saiz (Spain), Marie Galas (France) and Mahmoud Maina (UK / USA) during Session #3 chaired by Isabelle Landrieu & Yann Fichou.
He presented his PhD work on the Three zinc binding sites of Tau and their role in tau aggregation and little bit of the perspectives Dahbia Yatoui is currently working on right now.
On October, the 21st, Emmanuel was invited to give a talk during the 2021 meeting organized by the French Club of Glial Cells. Emmanuel had the chance to present the latest and exciting results of the NIVET team by giving a talk during a symposium dedicated on Glial cells in Brain diseases. Emmanuel's talk was entitled: "Human-iPSC-astrocytes reveal a pro-inflammatory axis under the control of the APOE4 genetic risk factor in Alzheimer's disease".
Félicitations à Chiara Bastiancich, post-doctorante dans l'équipe GlioME qui a obtenu la bourse de recherche fondamentale Élie Bzoura 2021, délivrée par la Société Française de Pharmacie Oncologique et à l' Académie nationale de Pharmacie pour son projet GlioRET.
Congratulations to Chiara Bastiancich, post-doctoral fellow in the GlioME team who has been awarded the Élie Bzoura research grant by the French Society of Oncology Pharmacy and the French National Academy of Pharmacy for her GlioRET project.
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