NeuroTimone Facility (PFNT)

The PFNT Facility is a coherent set of exploration tools in neurobiology allowing research at the molecular, cellular and integrated levels.

NCIS / PImaNT

PETRA“TECH”

PINT

qPCR

SCeNT

News

  1. New publication for the Neuro-inflammation and Multiple Sclerosis team (INP team 5) in Cytokine about the immunomonitoring of infliximab biotherapies

    From Tue. Nov 26 2019 to Thu. Dec 26 2019

    In this paper, Daniel Bertin evaluated the immunological follow-up of patients suffering from chronic inflammatory diseases and receiving anti-TNF biotherapy. Three commercial ELISA assays for monitoring soluble through levels of infliximab and anti-infliximab antibodies in serum showed a good global correlation of results. However, some quantitative discrepancies could change clinical decision. As a consequence, Daniel Bertin recommended to keep the same kit to perform a longitudinal follow-up of patients.
  2. Aurélie Tchoghandjian-Auphan, CRCN CNRS from the GlioME team, was recently granted by ARC fondation for her project "Effects of Smac mimetics treatment on glioblastomas immune response" .

    Wed. Nov 20 2019

    Aurélie Tchoghandjian-Auphan, CRCN CNRS from the GlioME team, in the Insitute of NeuroPhysiopathology, UMR CNRS 7051, was recently granted by ARC fondation for her project "Effects of Smac mimetics treatment on glioblastomas immune response".

    Subsequently she was interviewed by :
    - France 3  (JT 19/20 PACA diffusion du 15/11: 7'09 à 9'45) ; 
    - Provence Azur (18/11/2019) ;
    - 20 Minutes Marseille (18/11/2019)
    - La Provence

     
  3. DESU « Exploration et traitement des maladies auto-immunes »

    From Fri. Nov 15 2019 to Sat. Nov 30 2019

    Vous êtes médecin, pharmacien, interne en médecine ou biologie médicale et intéressé par les maladies auto-immunes et inflammatoires chroniques ?

    Dépêchez-vous, il ne reste que quelques places pour la session 2019-2020 du DESU « Exploration et traitement des maladies auto-immunes » (coordination : Dr Sophie Desplat-Jégo – Faculté de Médecine de Marseille). Inscriptions jusqu'au 30 novembre 2019.

  4. GlioME team in collaboration with INT (Institute of Neurosciences Timone) published a new study in Journal of Neuroinflammation on the effect of Bevacizumab on glioblastoma-bearing mice, using 2-photon imaging

    Thu. Nov 14 2019

    Our data show that VEGF blockade leads to an increased recruitment of monocytes and to an adjustment of dendritic cell subsets’ profiles, differing in their ability to induce an adaptive immune response. Altogether, they provide important new insights into the effects of Bevacizumab at the cellular level and into the spatio-temporal evolution of intra-tumoral innate immune cell densities.
  5. Pr Hervé Kovacic joins the editorial board of Antioxidant Redox Signaling

    Thu. Nov 07 2019

    The leading peer-reviewed journal dedicated to understanding of the vital impact of oxygen and oxidation-reduction (redox) processes on human health and disease, exploring key issues in genetic, pharmaceutical, and nutritional redox-based therapeutics.

    For more information, head to the ARS website.

  6. Marseille - Cassis 2019

    Sun. Oct 27 2019

    Congratulations to all the CNRS team for running the Marseille-Cassis race two weekends ago, and especially to Claude Villard (7th from the left, top row), INP team 9 and PINT facility member who ran this semi-marathon in 1 hour and 48 minutes.

    Next year, let's make a whole INP team (as usual, the race will take place on the last Sunday of October)!

    For more information, head to the race's official website.

  7. Anne-Marie François Bellan
    Listening to our molecular clocks

    Mon. Oct 07 2019

    During the NeuroStories event, held on Monday October 7 at the Faculty of Medicine, Anne-Marie François Bellan gave a remarkable stand up on how our body vibrates to the rhythm of internal chronometers called circadian clocks. She also explained how the molecular clock uses small corpuscles and cell space to make our genes rhythm.

    Click on the news to  see the video of her brilliant speech.

     

     

     

     

  8. Prof. D. Figarella-Branger, who belongs to the cIMPACT-NOW Working Committee, attended to the last meeting of the consortium in Utrecht (16-17 september).

    Tue. Sep 24 2019

    The cIMPACT-NOW Working Committee is the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy. cIMPACT-NOW  was created in late 2016 —following publication of the 2016 Updated 4th Edition of the World Health Organization (WHO) Classification of Tumours of the Central Nervous System— to provide a forum to evaluate and recommend proposed changes to future CNS tumor classifications.

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INP in numbers

  • 126 members
  • 44 researchers
  • 48 research assistants
  • 12 post-docs
  • 11 PhD

 

Poste pourvu : The Institute of NeuroPhysiopathology (INP) welcomes tenured researchers/lecturers, and junior researchers to lead or strengthen its research programmes

The Institute of NeuroPhysiopathology (INP) is a new laboratory of the CNRS/Aix-Marseille University created in 2018 that combines fundamental and translational research in a stimulating and friendly working environment (https://inp.univ-amu.fr). The INP is located on the Health Sciences Campus of La Timone, which is home to other leading neuroscience laboratories, bringing together more than 400 people covering a wide range of topics.

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Le label « Plateforme Technologique Aix-Marseille » de la PlateForme NeuroTimone PFNT a été renouvelé

Le label « Plateforme Technologique Aix-Marseille » de la PlateForme NeuroTimone PFNT a été renouvelé pour une nouvelle période de 3 ans par AMU, l’Inserm et le CNRS. Pour mémoire rappelons que la PFNT est constituée des plateformes NCIS, PINT et SCeNT de l’INP et de INPHIM de l’INT. La PFNT offre un éventail de prestations technologiques en neurobiologie au niveau local pour les équipes de recherche et start up de Marseille mais aussi au niveau régional et national.

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Performance théatralisée en hommage à Raphaël Dubois

Une production théâtrale et une performance artistique qui auront lieu le 8 décembre à 19h30 (suite au confinement, la performance a été reportée pour la prochaine saison). Cette représentation, produite par Nadia Merad Coliac, est une œuvre inédite. Elle aura lieu à Paris au théatre Reine Blanche, scène des arts et des sciences. C'est la première fois qu'elle travaille pour un théâtre.

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PINT new acquisitions: Biacore T200 & AKTA pure

The Platform INteractome Timone - PINT is pleased to announce the arrival of a brand new Surface Plasmon Resonance Biacore T200 (Cytiva, ex GE Healthcare) designed to follow in real time interactions between free-labeled biomolecules from ions to viruses. The use of real-time measurement allows to provide association (kon) and dissociation (koff) rate constant of the interaction and to deduce its affinity (KD).

English
dianette akta Geraldine biacore

MedIM 2020 : First inter-platform Interactome workshop

INP platform PINT together with AFMB and IMM are glad to announce their first inter-platform interactome workshop entitled "Methods to study Molecular Interactions (Biomedical applications)" that will take place from monday december 7th to friday 11th 2020. 

Looking to confirm the interaction between a drug and its target?
Wanting to characterize the interaction between a receptor and its ligand?

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New publication of the GlioME team.

In this paper we reported two uncommon adult cases of Diffuse Leptomeningeal Glioneuronal Tumors (DLGNTs) diagnosed after DNA-methylation profiling. This study enlarges the clinical and molecular spectrum of DLGNTs which encompass a wide spectrum of tumors that has yet to be fully clarified, and suggest that this terminology appears unsuitable in some cases.

English

Nanotemper Technologies 1st Virtual Symposium 

Romain La Rocca, third year PhD student in INP team 9 (Cytoskeleton and Neurophysiopathology), will present a part of his thesis work during the 1st NanoTemper Virtual Symposium on June 30th from 9 to 12h30. NanoTemper annual seminars bring together the researchers using NanoTemper instruments, or eager to discover new technologies and in different fields of research. During this event, Romain will show how to use the nanoDSF technology to study the quaternary structure of tubulin. 

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