L'Institut de NeuroPhysiopathologie (INP) est un centre d'excellence pour la formation et la recherche qui allie la recherche fondamentale et translationnelle pour étudier l'organisation, la fonction et l'interaction des cellules neurales, les bases moléculaires et cellulaires des principales maladies du cerveau, et développer des stratégies de thérapies cellulaires et moléculaires innovantes.
Equipes de recherche
Plateforme NeuroTimone (PFNT)
La PFNT (Plateforme NeuroTimone) est un ensemble cohérent d'outils d'exploration en neurobiologie permettant des investigations aux échelles moléculaires, cellulaires et intégrées.
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A commentary from Christophe Leterrier in the Journal of Cell BiologyChristophe Leterrier, leader of the NeuroCyto ATIP team, wrote a Spotlight in the Journal of Cell Biology highlighting a nice recent paper from the group of Pei-Lin Cheng in Taiwan. In this article, Lee et al. showed how degradation of the chloride transporter NKCC1 by proteasomes anchored at the AIS have a key role in lowering the intracellular chloride concentration, leading to the perinatal reversal of GABA effect from excitatory to inhibitory.
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2019 Retrospective: D. Figarella-Branger from the GlioME team was involved in 5 reference articles on pediatric brain tumoursThanks to her expertise in the diagnosis of central nervous system tumours arising in children and young adults, Dominique Figarella-Branger from the GlioME team (Team 8) was involved last year in 5 articles published in high-impact factor journals (>18). These articles are becoming references in this field:
- The molecular landscape of ETMR at diagnosis and relapse. Nature. 2019 Dec;576(7786):274-280. PMID: 31802000
- EANO-EURACAN clinical practice guideline for diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma. Lancet Oncol. 2019 Dec;20(12):e715-e728.PMID: 31797797
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"Alzheimer's disease: a year of hope" (La Marseillaise - January 2020)Maladie d'Alzheimer : une nouvelle année pleine d'espoir.
In its week-end edition (january the 4th & 5th 2020), the daily newspaper La Marseillaise devoted its "Provence Terre de Science" page to Alzheimer's disease reserach.
On this occasion François Devred (INP team 9 / PINT platform) answered a few questions on the molecular characterization of this complex protein (to be downloaded by clicking here )
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New publication of the NeuroCyto teamFirst work of 2020 work is out for the NeuroCyto team! A collaboration with Matt Rasband’s lab in Nature Communications. This is a significant paper for the axon initial segment field: Matt’s lab used BioID of key AIS proteins for mapping AIS components. Dozens of new candidates for future studies! We performed super-resolution microscopy of several of the newly identified AIS components. IN particular, we showed that Mical3, a protein linking microtubules and actin, forms clusters along the AIS that are not periodically organized along the actin/spectrin scaffold.
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France Culture highlights the recent article from the NeuroCyto teamIf you speak French, you can listen to “La Méthode Scientifique”, a program on the France Culture radio which highlighted the recent Nature Communications article from the NeuroCyto team.
You can go to the audio clip by following this link and learn more on the France Culture website.
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Just out from the NeuroCyto team: the ultrastructure of actin rings revealedOur work on the ultrastructure of the periodic actin/spectrin scaffold along axons is out in Nature Communications.
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INP & Vect-Horus first day off in Black Stone pubOn thursday december the 12th, most of INP and Vect-Horus members got together and spent a day in the Black Stone pub, Marseille, to celebrate the fact that nearly two years after its creation, the Institute of NeuroPhysiopathology is finally located on Tmone Campus.
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Michel KHRESTCHATISKY invited to the third edition of “Translational neuroscience Day: challenges and opportunities” co-organized by DHUNE and NeurATRISMichel KHRESTCHATISKY, Director of the UMR7051 Institute of Neurophysiopathology at Aix-Marseille University / CNRS and co-founder of VECT-HORUS was invited at the third edition of “Translational neuroscience Day: challenges and opportunities” co-organized by DHUNE and NeurATRIS and hosted by BioFIT on December 10, 2019 (https://www.biofit-event.com/translational-neuroscience).
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L'INP en chiffres
- 126 membres
- 44 chercheurs
- 48 chercheurs assistants
- 12 post-doctorants
- 11 doctorants
Laurie Arnaud from Team 1&6 has won the "Young Researcher Prize" for her poster presentation at the 4th edition of CALM 2020, organized by the Club Alzheimer de Montpellier
We are proud to announce that Laurie Arnaud, the third year PhD student in INP's Teams 1 and 6 (Neural Plasticity and Degeneration & Stem cells, Disease modeling and Neuroregeneration), recently won the Best Poster presentation prize at CALM 2020, the 4th edition, organized by the Club Alzheimer de Montpellier on the 17 and 18 of November 2020. She presented her work intitulated "Regulation of astrocyte inflammation by Apolipoprotein E (APOE): demonstration of an NF-kB-dependent mechanism mediated by a newly identified partner".
Semaine du cerveau 2021 : Notre cerveau : des neurones… et quoi d’autre ?
La 22ème édition de la « Semaine du Cerveau » s’adapte à la pandémie ! Plusieurs chercheurs de l’INP (Caroline Strube, Olivier Bosler et Anne-Marie François-Bellan) membres de l’association « cerveau point comm » participent à l’organisation au niveau régional de la Semaine du Cerveau, une manifestation internationale grand public coordonnée en France par la Société des Neurosciences.
L'équipe GlioME fière de la nomination de Chiara Bastiancich au Prix Départemental pour la recherche, section Jeune Chercheur
Mardi 16 février 2021, Chiara Bastiancich, Post-doc dans l'équipe GlioME faisait partie des 3 nominés en lice pour le prix "Jeune Chercheur" au 5ème Prix Départemental de la recherche en Provence organisé par le Département des Bouches du Rhône.
Poste pourvu : L’institut de NeuroPhysiopathologie (INP) à Marseille recrute un ingénieur d’études pour étudier les relations subcellulaires entre APP et MT5-MMP dans la maladie d'Alzheimer
Début Juin 2021 ; durée 2 ans ; financement Fondation Vaincre Alzheimer
Poste pourvu : Postdoctoral position at the Institute of Neurophysiopathology (INP) Marseille
A 3-year full-time postdoc position is open at the Institute of Neuropathophysiology (INP), CNRS/Aix-Marseille University to study pathogenic mechanisms of Alzheimer’s disease. The project should start in spring 2021.
Dominic Bingham (NeuroCyto team) at Neurobinar #5
On February 18 at 4 pm, come and discover the work of Pierre-Yves Jacob (LNC), Lucas Goirand-Lopez (INMED) and Dominic Bingham (INP, NeuroCyto team). Dominic Bingham and Lucas Goirand-Lopez will introduce their respective PhD in a cross-presentation. After a question session for PhD students, Pierre-Yves Jacob will share with us his research on the brain network underlying spatial navigation (displacement, orientation) in complex environments.
De "nouvelles têtes" dans l'équipe GlioME !
L'équipe GlioME a le plaisir d'accueillir actuellement 3 nouveaux étudiants (de gauche à droite sur la photo):
- Victoria Hein, doctorante en 1ère année, qui débute sa thèse sur le thème "Cellules souches de glioblastome et gangliosides : vers de nouvelles approches thérapeutiques", co-encadrée par Emeline Tabouret et Dominique Figarella-Branger.
Christophe Leterrier (NeuroCyto team) in Nature Materials
Christophe Leterrier from the NeuroCyto team just published a study in collaboration with the Cytomorpho lab - Manuel Théry & Laurent Blanchoin, CEA Paris/Grenoble.
Dominika Pilat (Team 1) on the Neurobinar #4 (NeuroMarseille) !
Dominika Pilat will be presenting on the Neurobinar #4 on January 21 at 4 pm on Zoom.
For this fourth edition, NeuroMarseille is pleased to welcome Cédric Maurange (IBDM), Dominika Pilat (INP) and Borloz Émilie (MMG). Dominika Pilat and Borloz Émilie will introduce their respective theses in a cross presentation. After a question session, Cédric Maurange (IBDM) will explain his research on genetic programmes modifying the properties of neural stem cells during development.
Partenaires
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