Christophe Leterrier, leader of the NeuroCyto ATIP team, wrote a Spotlight in the Journal of Cell Biology highlighting a nice recent paper from the group of Pei-Lin Cheng in Taiwan. In this article, Lee et al. showed how degradation of the chloride transporter NKCC1 by proteasomes anchored at the AIS have a key role in lowering the intracellular chloride concentration, leading to the perinatal reversal of GABA effect from excitatory to inhibitory.
Commentary:
GABA in, garbage out: AIS-located proteasomes regulate the developmental GABA switch.
Leterrier C.
The Journal of Cell Biology, 2020 Feb 3;219(2).
doi: 10.1083/jcb.201912006
Original article:
Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain.
Lee M, Liu Y, Chen C, Lu C, Lu S, Huang T, Hsu M, Hsueh Y, Cheng P.
The Journal of Cell Biology, 2020 Feb 3;219(2).
doi: 10.1083/jcb.201903033
