Séminaire

Par devred, 26 janvier, 2025
Event type
Conférencier

séminaire équipe 5- SinBiose

Start Date
Description

séminaire équipe 5- SinBiose

Place
SALLE 1
Par devred, 26 janvier, 2025
Event type
Conférencier

séminaire équipe 8 - Kostas Kostarelos, Head of Nanomedicine Lab, Institut Català de Nanociència i Nanotecnologia, Barcelona (Spain)

Start Date
Description

Kostas Kostarelos, Head of Nanomedicine Lab, Institut Català de Nanociència i Nanotecnologia, Barcelona (Spain)

Invité de l'équipe Gliome (membre du Jury d'HDR de Chiara Bastiancich)

Place
Salle 52 (5ème étage aile rouge)
Par devred, 26 janvier, 2025
Event type
Conférencier

séminaire équipe 11 NOSE - François Féron et Sabrina Rodrigues EN FRANCAIS

Start Date
Description

Cognitive trance: a new tool for well-being, the arts and medicine

 

What if we had been blind to part of our abilities? What if trance states were part of these abilities? What if trance had therapeutic effects? The trance research institute, which brings together nearly 400 researchers and clinicians, 280 psychologists and 326 other health professionals, has shown that the trance state is one of the non-ordinary states of consciousness in the same way as meditation or hypnosis. This state is accessible to everyone and allows us to connect with our inner selves and the living world. The augmented human being is perhaps not to be found in hyper-technology, but rather in our faculties, which we tend to neglect. During the seminar, Sabrina will present the broad outlines of her thesis work and several participants in her study, members of the laboratory, will talk about their experiences. 

 

La transe cognitive au service du bien-être, des arts et de la médecine

 

Et si nous avions été aveugles à une partie de nos capacités ? Et si les états de transe faisaient partie de ces capacités ? Et si la transe avait des effets thérapeutiques ? L’institut de recherche sur la transe, qui regroupe près de 400 chercheurs et cliniciens, 280 psychologues et 326 autres professionnels de santé, a montré que l’état de transe fait partie des états non ordinaires de conscience au même titre que l’état de méditation ou l’hypnose. Cet état est accessible à tous et permet à la fois de se connecter à son moi intérieur et au monde vivant. L’homme augmenté n’est peut-être pas à chercher dans l’hyper-technologie mais plutôt dans nos facultés que nous nous sommes ingéniés à ignorer ou minimiser. A l’occasion de ce séminaire, Sabrina présentera les grandes lignes de son travail de thèse et plusieurs participants de son étude, membres du laboratoire, témoigneront de leurs expériences. 

Place
Salle 52
Par devred, 26 janvier, 2025
Event type
Conférencier

séminaire équipe 10 Angiogenèse et Microenvironnement Tumoral - Chabane Norhimane - Vaccine Targeting Adrenomedullin System

Start Date
Description

séminaire équipe 10 Angiogenèse et Microenvironnement Tumoral - Chabane Norhimane - Vaccine Targeting Adrenomedullin System

Place
Salle 52
Par devred, 26 janvier, 2025
Event type
Conférencier

Chiara Bordier, étudiante en 2e année de thèse equipe 2 SynapTau

Start Date
Description

Understanding synaptic function is essential for investigating brain physiology and pathophysiological changes, such as those occurring in neurodegenerative diseases. Synaptosome isolation, which extracts synaptic terminals containing both pre- and post-synaptic components, provides a valuable tool for studying synaptic biology. Previous research suggests that synaptosome preparation from shock-frozen brain tissue, which is the most common source of human brain synaptosomes, generally yields synaptosomes with a lower respiratory rate, indicating potentially reduced biological functionality compared to fresh tissue. However, detailed comparative studies on the impact of freezing on synaptosome quality are lacking. Our research evaluates how fresh and frozen tissue differ in their suitability for synaptosome isolation, focusing on synaptic protein enrichment, non-synaptic contamination, and the preservation of functionality and structural integrity. We compared synaptosomes isolated from mouse brain tissue that was shock-frozen in liquid nitrogen, slowly frozen with a cryoprotective solution, and freshly processed. Western blot analysis and proteomic profiling were used to assess synaptic protein enrichment and non-synaptic contamination, which will be further validated by electron microscopy. Additionally, functionality assays will determine the impact of tissue state on synaptic exocytosis. Overall, this study aims to evaluate the efficacy of isolating synaptosomes from fresh versus frozen mouse brain tissue. Our findings will contribute to optimizing experimental approaches and improving the comparability of human and preclinical studies in synaptic research.

Place
salle 52
Par devred, 26 janvier, 2025
Event type
Conférencier

Julien Lefevre

Start Date
Description

Dans le cadre du digital clean up day, nous invitons Julien Lefevre de l'INT pour une conférence sur le numérique éco-responsable : bons usages individuels et enjeux globaux. 

 

Place
salle 52
Par devred, 26 janvier, 2025
Event type
Conférencier

Monique Esclapez invité de l'équipe 3

Start Date
Description
Vendredi 7 Mars 14h30 / Friday, March 7th at 14:30 pm
AMPHI CERIMED
 

 

 
En Introduction :

 "Présentation du Digital Clean Up day, auquel l'INP participe et challenge inter-équipes !"

par Louise, Denis et Montse



 

Monique ESCLAPEZ
 

Directeur de Recherche INSERM
 

invité par l'équipe 3
 


 

 

 

 

"The lateral Supramammillary nucleus (SuML) - Dentate Gyrus (DG) pathway contributes to the Epileptogenic Network In Mesial Temporal Lobe Epilepsies "
 


 

Mesial temporal lobe epilepsy (MTLE) is one of the most common drug-resistant partial epilepsies in both adults and children. It is characterized by spontaneous, recurrent seizures driven by excessive and hypersynchronous neuronal discharges originating from a multi-structural epileptogenic zone. This zone involves several regions of the limbic system within the mesial temporal lobe, including the hippocampal formation (HF), entorhinal cortex (EC), and amygdala. Electroclinical observations and studies in animal models provide strong evidence that MTLE is a network disorder. The emergence of spontaneous seizures not only requires hyperactivity of principal cells within the limbic cortex but also depends on the synchronization of activity across different limbic structures of the temporal lobe. The supramammillary nucleus (SuM) is a key subcortical structure that innervates the entire limbic cortex. It plays a crucial role in regulating hippocampal theta rhythms and functions such as REM sleep, emotional learning, and memory—processes that are impaired in MTLE. In this presentation, I will explore the unique properties of this network under physiological conditions and examine the functional impact of its reorganization in rodent models of MTLE. Our multidisciplinary approach combines optogenetics and electrophysiological recordings with structural connectivity and neurochemical techniques to provide new insights into the pathophysiology of MTLE.

Place
Amphi CERIMED