Simone Mastrogiacomo

Development of Brain Vectors for Therapeutics and Imaging Agents

Early Amyloid-β Deposits and Astrogliosis AreModulated by Housing Conditions in 5xFAD Mice

Epigenetic mechanisms in Alzheimer’s disease (AD) play a determining role in disease progression. To provided further insight on this matter, we evaluated whether early exposure of 5xFAD mice to either a standard, isolated or complex environment have a significant effect on the development of pathological hallmarks in this transgenic mouse model of AD. Accordingly, we manipulated the animal environment with different housing conditions that result in different cognitive and social stimuli. One month after birth followed by two months breeding under three different housing conditions, amyloid plaques and gliosis were evaluated. Our results demonstrated that both hallmarks were exacerbated in a complex environment and a bit less in isolated condition, in comparison with a standard social condition of housing. Thus, unexpectedly, an enriched environment conveying high behavioral stimulation can exacerbate the progression of the disease at least in the early stages. These data casts doubt on the general assumption that an enriched environment conveys beneficial effects on disease progression and suggest that strong environmental stimuli can be counterproductive, at least at the early stages of the pathology.

Il fait beau, il fait chaud!!! Pour marquer la fin de l'année (scolaire), nous vous proposons un apéro/Plage jeudi 3 juillet à partir de 18h sur la plage de l'Huveaune. Chacun amène un truc à partager (à boire ou à manger).

Bonne journée

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Hello everyone,

It's sunny, it's hot! To mark the end of the (school) year, we're hosting an aperitif/beach party on Thursday, July 3, starting at 6pm on the Huveaune beach. Everyone brings something to share (food or drink).

Have a nice day
 

L'équipe Animation

Présentation par Marseille Immunology Biocluster

En attente de précisions

Bonjour à tou.te.s

L'équipe animation vous propose de nous réunir mardi 6 mai à partir de 12h sur la pelouse devant le grand hall pour un pique nique printannier. Chacun amène son repas, sa boisson...

Bonne journée

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Hello everyone

The animation team invites you to join us on Tuesday May 6 from 12pm on the lawn in front of the main hall for a springtime picnic. Bring your own food and drink...

Have a nice day!

1et COPIL PFNT de l'année

Conseil de Laboratoire (CDL) #3 (initialement prévu le 26/09)

Conseil de Laboratoire (CDL)

Reunion de responsables d'équipe

Reunion responsables équipe