Bonjour à tou.te.s

L'équipe animation vous propose de nous réunir mardi 6 mai à partir de 12h sur la pelouse devant le grand hall pour un pique nique printannier. Chacun amène son repas, sa boisson...

Bonne journée

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Hello everyone

The animation team invites you to join us on Tuesday May 6 from 12pm on the lawn in front of the main hall for a springtime picnic. Bring your own food and drink...

Have a nice day!

1et COPIL PFNT de l'année

Conseil de Laboratoire (CDL) #3 (initialement prévu le 26/09)

Conseil de Laboratoire (CDL)

Reunion de responsables d'équipe

Reunion responsables équipe

Réunion de responsables d'équipe

Thaïs LESTRA 

Modulation of MT5-MMP in Alzheimer's disease and therapeutic modulation using viral-mediated transgenic strategies

Silvia Sposini is a Sir Henry Wellcome postdoctoral fellow at Imperial College London and visiting researcher at the Interdisciplinary Institute for Neurosciences in Bordeaux, France
 

Title :Imaging the dynamics of neuromodulator receptor trafficking

 

Summary:

G protein-coupled receptors (GPCRs) are the largest family of signalling receptors and the main targets of approved drugs. In the nervous system, they bind neuromodulators such as dopamine and noradrenaline to initiate signalling cascades that culminate in the modulation of neuronal functions such as excitability, synaptic transmission and plasticity, and, ultimately, behaviour.

Signalling from neuromodulator GPCRs occurs across extremely accurate spatial and temporal scales. For this, the tight but flexible tuning of GPCR signalling requires highly precise regulatory mechanisms, namely membrane trafficking.

Evidence for the physiological relevance of GPCR trafficking exists in neurons but remains scarce. Moreover, a detailed understanding of how these mechanisms are regulated and which specific cellular function they contribute to, is still missing.

My talk will focus on the information we have gathered so far on neuromodulator receptor trafficking at the molecular scale, with a focus on the tools we have implemented to achieve this. I will also cover our current efforts in understanding how trafficking of GPCRs to intracellular locations shapes neuronal physiology.