The SynapTau team is thrilled to announce the publication of our collaborative work. This has been an incredible partnership, and we are delighted to share our findings in the journal Life Science Alliance! In this paper, we demonstrated that parenchymal border macrophages (PBMs) function impedes tau pathology and tau-mediated neurodegeneration, while tau pathology promotes PBM dysfunction associated with impaired CSF flow. Our results identify PBMs as novel cellular regulators of tau pathology and tau-mediated neurodegeneration.
Read the article here: https://www.life-science-alliance.org/content/6/11/e202302087