L'Institut de NeuroPhysiopathologie (INP) est un centre d'excellence pour la formation et la recherche qui allie la recherche fondamentale et translationnelle pour étudier l'organisation, la fonction et l'interaction des cellules neurales, les bases moléculaires et cellulaires des principales maladies du cerveau, et développer des stratégies de thérapies cellulaires et moléculaires innovantes.
La PFNT (Plateforme NeuroTimone) est un ensemble cohérent d'outils d'exploration en neurobiologie permettant des investigations aux échelles moléculaires, cellulaires et intégrées.
We are please to welcome Guillaume Benhora-Chabeaux for his 5-month Master internship (2nd year) in the Nivet team. After obtaining a first Master degree in Cognitive Science (MASCO) from the Aix-Marseille University, with the highest honours, Guillaume has enrolled the Master in Neuroscience (cellular and molecular neuroscience). Guillaume will be working on the crosstalk between inflammation and a susceptibility to neurodegeneration using in vitro and in vivo models.
Dr Emmanuel Nivet has been appointed as a new member of the European Scientific Advisory Board (SAB) of a joint organization unifying the Alzheimer Forschung Initiative e.V. (AFI), Germany, Alzheimer Nederland (AN), The Netherlands and Fondation Vaincre Alzheimer (FVA), France. Each of the above organizations is dedicated to funding dementia research in its own country.
Membre expert du comité éditorial et co-auteur de plusieurs chapitres de la 5ème édition de la Classification des tumeurs du SNC de l’OMS parue le 12 novembre dernier, Dominique Figarella-Branger (Equipe 8 GlioME) a dirigé la rédaction d'un article de revue en français sur cette nouvelle classification, récemment publié dans les Annales de Pathologie: https://authors.elsevier.com/c/1eB1VtB1GOhjB
Un article de référence, facile d'accès, pour toute personne souhaitant être à la page sur la classification des tumeurs du SNC!
Team 9 (Cytoskeleton and Neurophysiopathology) and platform PINT (platform interactive Timone) are happy to see the almost simultaneous publications of two papers about about the impact of Zn2+ binding to NCS1 and to S100A1 respectively with their collaborators from Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, while the third one about Tau protein Zn2+ binding sites has been under review for already 3 months ...
The Cytoskeleton & Neurophysiopathology team and the GlioME team have a new publication out! Published on November 19th in Cancers, this article gives insights into how Tau regulates glioblastoma progression, via the PI3K-AKT signaling pathway.
Read the article here: https://www.mdpi.com/2072-6694/13/22/5818
On November 25 and 26, the conference "Digital Sciences and Artificial Intelligence for Health at Aix-Marseille University" was held in the Grisoli amphitheater & the Great Hall of the Faculty of Medical and Paramedical Sciences - Timone.
The aim of this conference was to formally bring together for the first time all the actors of Aix-Marseille University and the University Hospital Center involved in the digital and AI/health field, whether they are clinicians or theoreticians.
Les 25 et 26 novembre le colloque « Sciences numériques et Intelligence artificielle pour la Santé à Aix-Marseille Université » s'est tenu dans l'amphithéâtre Grisoli & le Grand Hall de la Faculté des Sciences Médicales et Paramédicales – Timone.
Ce colloque avait pour but de réunir formellement pour la première fois l’ensemble des acteurs d’Aix-Marseille Université et du Centre Hospitalier Universitaire impliqués dans le domaine numérique et IA|Santé qu'ils soient cliniciens-praticiens ou théoriciens.
Géraldine Ferracci (Ingénieur d’étude sur la plateforme PINT) a participé à la publication intitulée « Molecular landscape of BoNT/B bound to a membrane‑inserted synaptotagmin/ganglioside complex » qui est parue le 25 août 2022 dans Cellular and Molecular Life Sciences.
Abstract :
Après une période transitoire où il est resté sur le site de la faculté Nord, le spectromètre de masse de l'INP (Thermo Scientific Q-exactive) est arrivé sur le site Timone cet été. Maya Belghazi ayant quitté l'INP pour rejoindre l'IMM, Claude Villard est dorénavant votre seul interlocuteur pour les projets en lien avec cet appareil.
Congratulation to Vika post doc in team 9 (Cytoskeleton and NeuroPhysiopathology) for this great piece of work on Zinc Modulation of 3 families of Neuronal Calcium Sensor Proteins recently published in Biomolecules.
Après son report en 2021, l'inauguration du Centre d'Excellence Nikon pour la Neuro-NanoImagerie à Aix-Marseille Université (voir plus de détails sur le Centre d'Excellence ci-dessous) aura lieu le 22 Septembre 2022 à partir de 9h sur le campus Timone (amphithéatre Grisoli), en présence du Président d'AMU M. Eric Berton et du Directeur de Nikon Europe M. Takaharu Sasaoka.
Team 6 was happy to participate in NeuroMarseille's day, which took place on June 28, 2022.
Many members of the INP attended this scientific and friendly day for the neuroscience community.
Our M1 student, Marine Dos Santos, also presented her one-month work in our team, during the afternoon poster session.
We thank NeuroMarseille for this great day !
INP members from team 8 (GlioME: Gliomagenesis and MicroEnvironment) and team 9 (Cytoskeleton and Neurophysiopathology) attended the Canceropole PACA annual seminar which took place in Saint-Raphaël palais des congrés on July 5th and 6th 2022.
On the 20-22 nd June, the first Molecular Scale Biophysics Research Infrastructure (MOSBRI) conference was held in Paris. Dahbia Yatoui from team 9 and Géraldine Ferracci from PINT went to this event, where Dahbia had the opportunity to present her work "Role of zinc-binding sites in Tau aggregation" on a poster.
The GlioME team was represented on 8 and 9 June 2022 at the Sunrise (Solid tumor cancer stem cell network) meeting at the Curie Institute in Paris.
Aurélie Soubéran presented a poster on the role of the ML-IAP protein in glioblastoma growth and Aurélie Tchoghandjian presented the team's work on "Smac mimetic as pan-cellular therapy in glioblastoma".
After two years of being postponed, INP Day #2 finally took place on Friday, June 3rd.
A huge congrats and thank you to the organizing team (including our engineer Louise) for persevering and making this day a success!
Team 6 took the opportunity of this cheerful day to take a picture, with Marine our intern who is a M1 student.
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