The Institute of NeuroPhysiopathology (INP) is a training and research centre of excellence that combines basic and translational research to study neural cell organisation, function and interaction, the molecular and cellular bases of major brain diseases, and to develop innovative cellular and molecular therapeutic strategies.
The PFNT Facility is a coherent set of exploration tools in neurobiology allowing research at the molecular, cellular and integrated levels.
Laurie Arnaud (Neural Plasticity and Degeneration, Team 1 & Stem cells, Disease modeling and Neuroregeneration, Team 6) successfully defended her thesis on the 29th of September 2021. The jury was unanimous to acknowledge Laurie's hard work during her thesis at the INP.
Après avoir effectué son stage de Master 2 sur le sujet régulation des facteurs de transcription de la famille FOXO par l’adrénomédulline dans les cellules endothéliales vasculaires, Norhimane a rejoint l’équipe 10 en tant que doctorante à partir du 1er octobre 2021 grâce à une bourse de thèse financée par l’ARTC SUD. Elle mènera ses travaux de thèse sur la vaccination ciblée contre le système Adrenomédulline, une approche thérapeutique contre la croissance tumorale.
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Lors de leur deuxième année de Master en neurosciences, les étudiants effectuent un stage de 6 mois en laboratoire. Une véritable expérience de recherche !
Damien Caillol, qui a fait son stage au sein de l’INP dans l’équipe NOSE, nous fait part de son expérience.
Chiara, post-doctorante dans l'équipe 8 a participé au "Speed-Searching 2.0" à l'occasion de la nuit européenne des chercheurs 2021. Chiara a rencontré virtuellement 6 groupes de 4-5 personnes avec qui elle a échangé sur son parcours de pharmacienne et le développement de sa thématique de recherche "Traitement local à base de nanomédicament pour le glioblastome".
Chacun de ces groupes a pu comprendre les avantages et inconvénients de ces traitements à travers deux objets :
The INP is one of the winners of the photo contest organized by NeuroMarseille/NeuroSchool. The goal of the contest was to reveal the "beauty of life" through images taken in the neuroscience laboratories of AMU. Eight laboratories - INP, INT, IBDM, LNC, INMED, INS, LPC, CRMBM - sent pictures (5 for INP). The first 10 works have been selected and will soon be exhibited in a gallery in Marseille and another in Aix en Provence. Those not selected will appear in the printed catalog of the exhibition.
The INP is proud to announce that, this year, four of its members have had their projects successfully granted by the French National Research agency (ANR - generic call 2021): Pascale Barbier (team 9), Christophe Leterrier (team 7), Emmanuel Nivet (team 6) and Aurélie Tchoghandjian (team 8).
La saison estivale est déjà amorcée, certains sont déjà en vacances (la chance !) et d'autres font de la résistance au labo. Le comité des fêtes de l'INP en a profité pour réunir les présents autour d'un pique-nique, juste avant le déménagement de l'équipe 8 !
Joyeuses vacances estivales à tous. Que nous revenions tous reposés, motivés et pleins d'ambitions et d'idées pour de belles recherches scientifiques à accomplir à la rentrée :-)
The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS), is the sixth version of the international standard for the classification of brain and spinal cord tumors. Building on the 2016 updated fourth edition and the work of the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy (cIMPACT-NOW), the 2021 fifth edition introduces major changes that advance the role of molecular diagnostics in CNS tumor classification.
Chiara Bastiancich, Post-doc in the GlioME team presented her ongoing GlioRET project at the European Symposium on Controlled Drug Delivery.
Her poster "Elucidating the tumor resection microenvironment of glioblastoma toward the development of fit-for-purpose local treatments" won over the cogress jury !
Emmanuel Snacel-Fazy, a 2nd year doctoral student in the GlioME team, won the best poster award at yesterday's "Conference Annuelle de L'institut Cancer et Immunologie (ICI)", Thursday 31 March 2022.
His work on the "Remodelling of the glioblastoma immune landscape by smac mimetic GDC-0152" has been appreciated and rewarded. Once again, congratulations!
Dr Romain Appay, pathologist at the Timone Hospital and PhD student in the GioME team, has published a new research paper entitled "Rosette-forming glioneuronal tumours are midline, FGFR1- mutated tumours" in the Neuropathology and Applied Neurobiology journal.
The latest article for NPD team 1 has been published this month into the Journal of Neuroinflammation.
Membrane-type matrix metalloproteinase 5 (MT5-MMP) deficiency in the 5xFAD mouse model of Alzheimer's disease reduces brain neuroinflammation along with amyloidosis, and prevents deficits in synaptic activity and cognition in prodromal stages of the disease. In addition, MT5-MMP deficiency prevents interleukin-1 beta (IL-1β)-mediated inflammation in the peripheral nervous system.
Don't miss the next Neuro'binar of NeuroMarseille with Emmanuel Nivet (Team 6) !
Next Tuesday, on March 22nd, 2022, at 1 pm online, discover Dr Emmanuel Nivet's work in the 13th edition of Neuro'binar:
🔘 Emmanuel Nivet (INP) will present his research topic entitled: "Human induced pluripotent stem cells to study the role of astrocytes in Alzheimer’s disease"
If you want to know more about the treatment of glioblastoma with Gold Nanorods, click on the title "Well-Defined Polyethylene Glycol Microscale Hydrogel Blocks Containing Gold Nanorods for Dual Photothermal and Chemotherapeutic Therapy" , a publication co-authored by Chiara Bastiancich, post-doc in the GlioME team.
Application Deadline : 30 September 2023
General information
Reference : UMR7051-MAUGRA-001
Number of position : 1
Workplace : MARSEILLE 05
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 January 2024
Proportion of work : Full time
Remuneration : Between €2,932 and €4,669 gross per month depending on experience.
Desired level of education : Niveau 8 - (Doctorat)
Experience required : Indifferent
To nicely end 2021 year, Dominika Pilat, student in Neural Plasticity and Degeneration Team (Team 1), successfully defended her thesis on the 16th of December. She gave a very clear, precise and comprehensive presentation highlighting the pivotal role of MT5-MMP in the neuroinflammation in an Alzheimer’s Disease model.
Participating in the virtual conference "Tumor Microenvironment Heterogeneity in Cancer Progression: Challenge or Opportunity", Emmanuel Snacel-Fazy, a 2nd year PhD student in the GlioME team won the prize for the best presentation on the "Remodeling of the glioblstoma immune landscape by smac mimetic GDC-0152".
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