The Institute of NeuroPhysiopathology (INP) is a training and research centre of excellence that combines basic and translational research to study neural cell organisation, function and interaction, the molecular and cellular bases of major brain diseases, and to develop innovative cellular and molecular therapeutic strategies.
The PFNT Facility is a coherent set of exploration tools in neurobiology allowing research at the molecular, cellular and integrated levels.
Membre expert du comité éditorial et co-auteur de plusieurs chapitres de la 5ème édition de la Classification des tumeurs du SNC de l’OMS parue le 12 novembre dernier, Dominique Figarella-Branger (Equipe 8 GlioME) a dirigé la rédaction d'un article de revue en français sur cette nouvelle classification, récemment publié dans les Annales de Pathologie: https://authors.elsevier.com/c/1eB1VtB1GOhjB
Un article de référence, facile d'accès, pour toute personne souhaitant être à la page sur la classification des tumeurs du SNC!
Team 9 (Cytoskeleton and Neurophysiopathology) and platform PINT (platform interactive Timone) are happy to see the almost simultaneous publications of two papers about about the impact of Zn2+ binding to NCS1 and to S100A1 respectively with their collaborators from Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, while the third one about Tau protein Zn2+ binding sites has been under review for already 3 months ...
The Cytoskeleton & Neurophysiopathology team and the GlioME team have a new publication out! Published on November 19th in Cancers, this article gives insights into how Tau regulates glioblastoma progression, via the PI3K-AKT signaling pathway.
Read the article here: https://www.mdpi.com/2072-6694/13/22/5818
On November 25 and 26, the conference "Digital Sciences and Artificial Intelligence for Health at Aix-Marseille University" was held in the Grisoli amphitheater & the Great Hall of the Faculty of Medical and Paramedical Sciences - Timone.
The aim of this conference was to formally bring together for the first time all the actors of Aix-Marseille University and the University Hospital Center involved in the digital and AI/health field, whether they are clinicians or theoreticians.
Plusieurs chercheurs de la communauté marseillaise des neurosciences, notamment l’équipe d’Agnès Trébuchon, mènent des recherches sur les fondamentaux et les effets thérapeutiques de la transe cognitive auto-induite. Tout comme l’hypnose ou la méditation, il s’agit d’un état modifié de conscience, induit par la seule volonté de chacun. A l’occasion de la création par Paris VIII du premier diplôme universitaire (DU/DESU) sur cette pratique, Le Monde a consacré une double page aux recherches menées par l’Institut international de recherches sur la transe (TranceScience), présidé par François Féron (équipe NOSE, INP)
Neural Plasticity and Degeneration team has recently welcomed Shweta SONAWANE.
Shweta is from Mumbai (India) she did her Ph.D. at the Biochemical sciences division of CSIR - National Chemical Laboratory in Pune (India).
Her doctoral research was largely focused on Tau pathology in Alzheimer’s disease studying in particular the effect of glycated and phosphorylated Tau on cytoskeleton integrity as well as aggregation propensity in order to find small molecules that could attenuate Tau aggregation and prevent its glycation.
The NeuroCyto team has a new publication out! Published on November 5th in Science, this article elucidates how adenosine A2A receptors drive removal of inhibitory synapses depending on their activity. This is a fruitful collaboration with the labs of Sabine Lévi at Institut du Fer à Moulin (IFM) in Paris and Christophe Bernard at Institut de Neuroscience des Systèmes (INS) in Marseille. Read the article here: https://www.science.org/doi/10.1126/science.abk2055
Géraldine Ferracci (Study Engineer on the PINT platform) participated in the publication entitled "Molecular landscape of BoNT/B bound to a membrane inserted synaptotagmin/ganglioside complex" which appeared on August 25, 2022 in Cellular and Molecular Life Sciences.
Abstract :
Après une période transitoire où il est resté sur le site de la faculté Nord, le spectromètre de masse de l'INP (Thermo Scientific Q-exactive) est arrivé sur le site Timone cet été. Maya Belghazi ayant quitté l'INP pour rejoindre l'IMM, Claude Villard est dorénavant votre seul interlocuteur pour les projets en lien avec cet appareil.
Congratulation to Vika post doc in team 9 (Cytoskeleton and NeuroPhysiopathology) for this great piece of work on Zinc Modulation of 3 families of Neuronal Calcium Sensor Proteins recently published in Biomolecules.
After being postponed in 2021, the inauguration of the Nikon Center of Excellence for Neuro-Nanoimaging at Aix-Marseille Université (see more details on the Center of Excellence below) will take place on September 22, 2022 starting at 9:00 am on the Timone campus (Grisoli amphitheater), in the presence of the President of AMU Mr. Eric Berton and the Director of Nikon Europe Mr. Takaharu Sasaoka.
Team 6 was happy to participate in NeuroMarseille's day, which took place on June 28, 2022.
Many members of the INP attended this scientific and friendly day for the neuroscience community.
Our M1 student, Marine Dos Santos, also presented her one-month work in our team, during the afternoon poster session.
We thank NeuroMarseille for this great day !
INP members from team 8 (GlioME: Gliomagenesis and MicroEnvironment) and team 9 (Cytoskeleton and Neurophysiopathology) attended the Canceropole PACA annual seminar which took place in Saint-Raphaël palais des congrés on July 5th and 6th 2022.
On the 20-22 nd June, the first Molecular Scale Biophysics Research Infrastructure (MOSBRI) conference was held in Paris. Dahbia Yatoui from team 9 and Géraldine Ferracci from PINT went to this event, where Dahbia had the opportunity to present her work "Role of zinc-binding sites in Tau aggregation" on a poster.
The GlioME team was represented on 8 and 9 June 2022 at the Sunrise (Solid tumor cancer stem cell network) meeting at the Curie Institute in Paris.
Aurélie Soubéran presented a poster on the role of the ML-IAP protein in glioblastoma growth and Aurélie Tchoghandjian presented the team's work on "Smac mimetic as pan-cellular therapy in glioblastoma".
After two years of being postponed, INP Day #2 finally took place on Friday, June 3rd.
A huge congrats and thank you to the organizing team (including our engineer Louise) for persevering and making this day a success!
Team 6 took the opportunity of this cheerful day to take a picture, with Marine our intern who is a M1 student.
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