The PFNT Facility is a coherent set of exploration tools in neurobiology allowing research at the molecular, cellular and integrated levels.
First work of 2020 work is out for the NeuroCyto team! A collaboration with Matt Rasband’s lab in Nature Communications. This is a significant paper for the axon initial segment field: Matt’s lab used BioID of key AIS proteins for mapping AIS components. Dozens of new candidates for future studies! We performed super-resolution microscopy of several of the newly identified AIS components. IN particular, we showed that Mical3, a protein linking microtubules and actin, forms clusters along the AIS that are not periodically organized along the actin/spectrin scaffold.
If you speak French, you can listen to “La Méthode Scientifique”, a program on the France Culture radio which highlighted the recent Nature Communications article from the NeuroCyto team.
You can go to the audio clip by following this link and learn more on the France Culture website.
Our work on the ultrastructure of the periodic actin/spectrin scaffold along axons is out in Nature Communications.
In a large cohort of 911 high-grade IDH-mutant gliomas from the French national POLA network, we investigated the prognostic value of the CDKN2A gene homozygous deletion as well as WHO grading criteria (mitoses, microvascular proliferation, and necrosis).
We showed that:
- CDKN2A homozygous deletion characterizes diffuse malignant IDH-mutant gliomas with worst outcome.
- Microvascular proliferation stratifies IDH-mutant gliomas lacking CDKN2A homozygous deletion.
On thursday december the 12th, most of INP and Vect-Horus members got together and spent a day in the Black Stone pub, Marseille, to celebrate the fact that nearly two years after its creation, the Institute of NeuroPhysiopathology is finally located on Tmone Campus.
Michel KHRESTCHATISKY, Director of the UMR7051 Institute of Neurophysiopathology at Aix-Marseille University / CNRS and co-founder of VECT-HORUS was invited at the third edition of “Translational neuroscience Day: challenges and opportunities” co-organized by DHUNE and NeurATRIS and hosted by BioFIT on December 10, 2019 (https://www.biofit-event.com/translational-neuroscience).
Maeva and Noé presented their poster at the SFNano C'Nano conference entitled "Preclinical evaluation of a paclitaxel nanoprodrug for glioblastoma therapy".
L'équipe 5 a le plaisir d'accueillir en stage du 1er décembre 2019 au 31 mars 2020, Théo Loignon étudiant à l'école d'ingénieur de Bordeaux ei.cesi. Théo travaillera avec Jean-Philippe Dales sur l'imagerie chimique du tissu nerveux au cours de la neuroinflammation.
Dans la semaine du lundi 07 décembre au vendredi 11 décembre s'est tenue avec succès la première édition de l'atelier MedIM (Methodes d'étude des Interactions Moléculaires) co-organisé par la Plateforme INteractome Timone (PINT) de l’INP, la plateforme de Biologie Structurale de l’AFMB et les plateformes de l’IMM, toutes trois labellisées "Plateformes Technologiques du site d'Aix-Marseille".
The NeuroCyto team led by Christophe Leterrier was awarded two collaborative ANR grants in the 2020 call. The first project, “How actin/spectrin scaffold shapes axonal physiology” (ASHA), is coordinated by C. Leterrier in collaboration with the teams of Stéphane Vassilopoulos (Institut de Myologie, Paris) and Emmanuel Nivet at INP.
Laurie Arnaud will be presenting on the Neurobinar #3 on December 17 at 4 pm on Zoom.
For this third edition, NeuroMarseille is pleased to welcome Christelle Baunez (INT), Laurie Arnaud (INP) and Nada El Mahmoudi (LNSC/LNC). Laurie Arnaud and Nada El Mahmoudi will introduce their respective theses in a cross presentation. After a question and answer session, Christelle Baunez (INT) will explain her research on the role of basal ganglia (GB) in motivation and reward processes.
A successful partnership between the APHM Pathology department / the GlioME team and ID-Solutions industrial society (https://www.id-solutions.fr/fr/), has led to the developement of ready-to-use kits for the detection and quantification by digital PCR of key genetic alterations of brain tumours, specifically gliomas.