Suite au discours du président de la République et conformément à ce qui avait été préparé dans le cadre du Plan de Continuité des Activités Pédagogiques, Administratives et de Recherche d'Aix Marseille Université et du CNRS, l'ensemble du personnel de l'INP continuera a travailler de chez soi à compter de ce lundi 16 mars 2020.

En raison des mesures prises pour freiner l'épidémie COVID-19, cette causerie est bien évidemment annulée ...

Romain La Rocca, third year PhD student in INP team 9 (Cytoskeleton and Neurophysiopathology), recently won the the best poster prize at the 4th ARBRE-MOBIEU pleanry meeting in Prague on February 24, 25 and 26.

ARBRE MOBIEU pleanry meeting is a European Biophysics Congress that brings together many researchers in Europe from various fields, all of whom have in common the use of biophysical tools. On this occasion, Romain presented his thesis work on the effects of zinc on the Tau protein using NMR, ITC, DLS among other biophysical techniques.

Our study shows that a treatment with the microtubule-destabilizing agent BAL101553 counteracts tumor angiogenesis by acting on glioblastoma stem-like cells, in an EB1-dependent manner. This work provides new insights into the therapeutic targeting of cancer stem-like cells.

Au printemps 2019, le CNRS a lancé un appel à projets, pour la 3e année consécutive, dans l’optique de l’amélioration de la Qualité de Vie au Travail (QVT)...                                                                                                    

• The Emergence project entitled “New high throughput screening method for anticancer agents” carried out by Philipp Tsvetkov (first from the right) was selected by the Canceropole PACA to be funded by the GEFLUC (groupement des entreprises françaises dans la lutte contre le cancer).

Aurélie Tchoghandjian a soutenu son Habilitation à Diriger les Recherches (HDR) devant un jury d'experts composé de cliniciens : Pr. Nicolas André, Pr. François Ducray, Pr. Dominique Figarella-Branger; et de chercheurs : Dr. Emmanuelle Huillard et Dr. Monique Dontenwill.

As part of her PhD, Sylvie Carmona investigated the beneficial effects of NV669, an aminosterol derived from squalamine on human pancreatic and hepatic cancer models. In vitro results exposed in this paper showed that NV669 inhibited the proliferation of cancer cells, induced cell cycle arrest and subsequent apoptosis. Moreover, NV669 inhibited PTP1B activity and impacted adhesion molecules expression. This suggests that NV669 by inhibiting PTP1B would affect cell contacts and would induce apoptosis.