In collaboration with the Holtzman lab., Maud Gratuze, with her colleagues Monica Xiong and Chao Wang, published an article on a project developed during her postdoc in the USA. In this study, entitled "Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy" and recently published in Molecular Neurodegeneration, they reduced ApoE4, the strongest genetic risk factor in Alzheimer’s disease, specifically derived from astrocytes in a mouse model of cerebral amyloid angiopathy. The selective removal of astrocytic ApoE4 is sufficient to reduce Aβ-mediated gliosis and cerebrovascular dysfunction, despite increased cerebral amyloid angiopathy.
Find the paper here : https://trebuchet.public.springernature.app/get_content/f7f42006-c3b0-466e-b30e-a6831ac0ff25
