The PFNT Facility is a coherent set of exploration tools in neurobiology allowing research at the molecular, cellular and integrated levels.
Our team is pleased to welcome Mensah Loko for a 6 months Master internship (from November 2022) in Integrative Biology and Physiology: Integrative approach to the functions of life: from gene to pathology. The subject of his internship is the role of Adrenomedullin expressed by glioblastoma-associated endothelial cells in promoting a stable and functional angiogenesis.
We are happy to celebrate the release of 3 first author papers on Myotoxin-3 from a snake venom as a new microtubule targeting agent, on the mechanism of action of Zinc induced aggregation of tau, and a review article on tau as a therapeutic target for cancer, for team 9 three PhD students : Cecilia, Dahbia and Rayane, this month :
Clara Camilla, PhD student, Biology-Health - Oncology speciality, is starting her thesis on the theme: "Evaluation of Longitudinal Genomic Alterations in Diffuse Low Grade Gliomas in Adults".
Emeline Tabouret and Aurélie Tchoghandjian, in collaboration with Thierry Virolle's team at the l'Institut de Biologie Valrose in Nice, are among the two winners to have obtained "Action structurante" funding from the Cancéropôle PACA.
This funding aims to structure the neuro-oncology at the preclinical and translational level in the region (between Marseille and Nice) and will be used to create the PETRA (PrEclinical and TRAnslational Research) platform on these two sites.
Chiara Bastiancich published the last article of her first postdoc on GRAVITY project 🎉
The challenging goal was: delivering to the brain metallic nanoparticles via focused ultrasound-mediated blood-brain barrier (BBB) permeabilization, to heat them using lasers for glioblastoma photothermal therapy! In this paper she shows one of the steps to reach this daunting task.
Géraldine Ferracci (Study Engineer on the PINT platform) participated in the publication entitled "Molecular landscape of BoNT/B bound to a membrane inserted synaptotagmin/ganglioside complex" which appeared on August 25, 2022 in Cellular and Molecular Life Sciences.
Abstract :
Après une période transitoire où il est resté sur le site de la faculté Nord, le spectromètre de masse de l'INP (Thermo Scientific Q-exactive) est arrivé sur le site Timone cet été. Maya Belghazi ayant quitté l'INP pour rejoindre l'IMM, Claude Villard est dorénavant votre seul interlocuteur pour les projets en lien avec cet appareil.
Congratulation to Vika post doc in team 9 (Cytoskeleton and NeuroPhysiopathology) for this great piece of work on Zinc Modulation of 3 families of Neuronal Calcium Sensor Proteins recently published in Biomolecules.
Nathalie et Aurélie ont eu le plaisir d'accueillir dans l'équipe Lucas Gola, élève de première du Lycée Notre Dame de France dans le cadre du dispositif "Apprentis Chercheurs" porté par l'association "Arbre des connaissances".
Le projet « Validation de nouveaux agents ciblant les microtubules et pouvant traverser la barrière hémato-encéphalique pour le traitement du glioblastome » déposé à l’appel « Repositionnement de molécules en prématuration » du Canceropôle Provence Alpes Côte d’Azur par Philipp Tsvetkov (plateforme PINT) a été retenu par le Comité Scientifique du Canceropole PACA pour être financé à hauteur de 30 000 euros. Sont impliquées dans ce projet les équipes 9 et 8 et leurs plateformes associées respectives
Part of Team 8 was present at the ICI (Institute of Cancer and Immunology) congress on April 6.
On this occasion, Aurélie Tchoghandjian presented the PETRA network and Sokhna Babou (Master 2 student) and Emmanuel Snacel-Fazy (PhD student) discussed their results with the scientific community during the poster session.
Team 8 has recently obtained a CMA-CGM funding in the framework of the call for projects "Programme d'équipement et de recherche clinique" 2022
The project title is "Program of Precision RAdioTherapy to Improve patient Cancer treatment" and aims to participate in the purchase of a small animal irradiator "SARRP" that will complement the pre-clinical offerings of the PETRA network.