The Institute of NeuroPhysiopathology (INP) is a training and research centre of excellence that combines basic and translational research to study neural cell organisation, function and interaction, the molecular and cellular bases of major brain diseases, and to develop innovative cellular and molecular therapeutic strategies.
The PFNT Facility is a coherent set of exploration tools in neurobiology allowing research at the molecular, cellular and integrated levels.
The NeuroCyto team has a new publication out! Published on November 5th in Science, this article elucidates how adenosine A2A receptors drive removal of inhibitory synapses depending on their activity. This is a fruitful collaboration with the labs of Sabine Lévi at Institut du Fer à Moulin (IFM) in Paris and Christophe Bernard at Institut de Neuroscience des Systèmes (INS) in Marseille. Read the article here: https://www.science.org/doi/10.1126/science.abk2055
The NeuroCyto team has a new publication out! Published on Sep. 15 in Neuron, this article reveals how clathrin is slowly transported along axons by forming transport packets that are then docked at presynapses where they can dynamically supply clathrin for synaptic function. This is another episode of the long-standing collaboration between the NeuroCyto team and the lab of Subhojit Roy at UCSD. Read the article here: https://doi.org/10.1016/j.neuron.2021.08.016
Nadia Coliac a été l’auteure, metteuse en scène et scénographe d’une expérience théâtrale bioluminescente qui a eu lieu le 19 octobre dernier à Paris sur la scène des arts et des sciences du théâtre de la Reine Blanche. Une expérience grandeur nature d'éclairer tout un théâtre uniquement avec la lumière vivante qui a captivé le public, ce fut un moment magique !
Cette production artistique et scientifique fait partie de ses recherches dans le domaine de l'histoire des sciences pour réhabiliter la mémoire de " Raphaël Dubois génie de la lampe vivante".
PINT platform recently acquired the NT.Robotic Autosampler that complemented the existing Prometheus NT.Plex nanoDSF instrument which is already equipped with aggregation detection optics to get complete stability characterization.
NT.Robotic Autosampler is a stand-alone, all-inclusive system with robotic arm, computer, and monitor. PINT is now able to analyze up to 1,536 samples for hands-free characterization of thermal unfolding and chemical denaturation in a single experiment. Incorporate plate temperature control to keep your samples at 4 to 20 °C while they wait in the queue.
This will permit to scale up the existing applications of the Prometheus :
Romain La Rocca, former member of INP team 9, shared the stage of EuroTau meeting in Lille's Grand Palais with Illana Gozes (Israel), Cláudio M. Gomes (Portugal), Amandine Grimm (Switzerland), Yann Fichou (France), Marina Rierola (Germany), Laura Vallés Saiz (Spain), Marie Galas (France) and Mahmoud Maina (UK / USA) during Session #3 chaired by Isabelle Landrieu & Yann Fichou.
He presented his PhD work on the Three zinc binding sites of Tau and their role in tau aggregation and little bit of the perspectives Dahbia Yatoui is currently working on right now.
On October, the 21st, Emmanuel was invited to give a talk during the 2021 meeting organized by the French Club of Glial Cells. Emmanuel had the chance to present the latest and exciting results of the NIVET team by giving a talk during a symposium dedicated on Glial cells in Brain diseases. Emmanuel's talk was entitled: "Human-iPSC-astrocytes reveal a pro-inflammatory axis under the control of the APOE4 genetic risk factor in Alzheimer's disease".
Félicitations à Chiara Bastiancich, post-doctorante dans l'équipe GlioME qui a obtenu la bourse de recherche fondamentale Élie Bzoura 2021, délivrée par la Société Française de Pharmacie Oncologique et à l' Académie nationale de Pharmacie pour son projet GlioRET.
Congratulations to Chiara Bastiancich, post-doctoral fellow in the GlioME team who has been awarded the Élie Bzoura research grant by the French Society of Oncology Pharmacy and the French National Academy of Pharmacy for her GlioRET project.
Aurélie Tchoghandjian (équipe 8 - GlioME) a obtenu un financement "Emergence" pour son projet intitulé "Création d’une lignée syngénique murine de cellules souches de glioblastome reproduisant l’hétérogénéité moléculaire et cellulaire des glioblastomes pour combattre la résistance thérapeutique" et Gilles Breuzard (équipe 9 - Cytosquelette et Physiopathologie) pour son projet intitulé "La protéine Tau comme nouvelle cible thérapeutique des glioblastomes : focus sur de nouveaux dérivés des thiazoloflavones "
Congratulation to Vika post doc in team 9 (Cytoskeleton and NeuroPhysiopathology) for this great piece of work on Zinc Modulation of 3 families of Neuronal Calcium Sensor Proteins recently published in Biomolecules.
After being postponed in 2021, the inauguration of the Nikon Center of Excellence for Neuro-Nanoimaging at Aix-Marseille Université (see more details on the Center of Excellence below) will take place on September 22, 2022 starting at 9:00 am on the Timone campus (Grisoli amphitheater), in the presence of the President of AMU Mr. Eric Berton and the Director of Nikon Europe Mr. Takaharu Sasaoka.
Team 6 was happy to participate in NeuroMarseille's day, which took place on June 28, 2022.
Many members of the INP attended this scientific and friendly day for the neuroscience community.
Our M1 student, Marine Dos Santos, also presented her one-month work in our team, during the afternoon poster session.
We thank NeuroMarseille for this great day !
INP members from team 8 (GlioME: Gliomagenesis and MicroEnvironment) and team 9 (Cytoskeleton and Neurophysiopathology) attended the Canceropole PACA annual seminar which took place in Saint-Raphaël palais des congrés on July 5th and 6th 2022.
On the 20-22 nd June, the first Molecular Scale Biophysics Research Infrastructure (MOSBRI) conference was held in Paris. Dahbia Yatoui from team 9 and Géraldine Ferracci from PINT went to this event, where Dahbia had the opportunity to present her work "Role of zinc-binding sites in Tau aggregation" on a poster.
The GlioME team was represented on 8 and 9 June 2022 at the Sunrise (Solid tumor cancer stem cell network) meeting at the Curie Institute in Paris.
Aurélie Soubéran presented a poster on the role of the ML-IAP protein in glioblastoma growth and Aurélie Tchoghandjian presented the team's work on "Smac mimetic as pan-cellular therapy in glioblastoma".
After two years of being postponed, INP Day #2 finally took place on Friday, June 3rd.
A huge congrats and thank you to the organizing team (including our engineer Louise) for persevering and making this day a success!
Team 6 took the opportunity of this cheerful day to take a picture, with Marine our intern who is a M1 student.
Journée Interdisciplinarité(s) organisée par AMU.
On vous attend nombreux le 18 juin au Cube (Faculté des Lettres à Aix en Provence) pour assister à la manifestation Scientifica pour une séance de rattrapage pour une installation immersive "Porteur de lumière".
Pour plus d'information, veuillez consultez le programme.
Les 2 et 3 juin derniers, les équipes de l'INP ont profité d'une installation de bioluminescence à l’occasion de la fête de l'INP.
On 19 and 20 May 2022 the GlioME team represented the INP at the "Brain tumor Meeting" in Berlin with the presentation of 6 posters:
- Chiara Bastiancich who won the 2nd poster prize: CHARACTERIZATION OF THE GLIOBLASTOMA RESECTION MICROENVIRONMENT AS THERAPEUTIC TARGET TOWARDS THE DEVELOPMENT OF LOCAL TREATMENT
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