NOSE. Nasal Olfactory Stemness and Epigenesis

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The olfactory mucosa is home of a permanent neurogenesis. Our team was the first to identify and characterise the adult ecto-mesenchymal stem cells residing in the human nasal olfactory lamina propria. These easily accessible cells, located in a nervous tissue, allowed us to find new candidate genes in brain pathologies. We successfully identified specific risk factors for Parkinson’s disease, schizophrenia and bipolar disorders. We also demonstrated a misexpression of molybdenum enzymes and a perturbed purine metabolism in autistic patients. Currently, we perform frontline sequencing techniques (genome, transcriptome, metabolome) to unveil common phenotypes in autism spectrum disorders.

We also used olfactory stem cells to repair the brain. We transplanted undifferentiated stem cells in animal models of amnesia and Parkinson’s disease. In both cases, grafted cells differentiated and improved the host behaviour, namely learning abilities or locomotion. We also devised a protocol enabling an in vitro transdifferentiation into dopaminergic neurons. In parallel, we conducted a series of experiments based on the grafting of olfactory stem cells in injured peripheral nerves. Two pilot clinical trials, based on the autologous transplantation of olfactory stem cells in patients with a lesioned facial or hand nerve, are currently implemented.   

News

  1. Mon stage de M2 à l'INP - Damien Caillol

    Lors de leur deuxième année de Master en neurosciences, les étudiants effectuent un stage de 6 mois en laboratoire. Une véritable expérience de recherche !

    Damien Caillol, qui a fait son stage au sein de l’INP dans l’équipe NOSE, nous fait part de son expérience.         

  2. Hybrid Art 2021, Port de Bouc
    Le jury d'Hybrid Art du centre d'art Fernand Léger a retenu le dossier de Nadia Coliac pour l' édition 2021

    Pour Hybrid’Art 2021, l’artiste-chercheure observe la bioluminescence exposée à l’air libre, à la température ambiante pour analyser l’impact de l’oxygène sur la durée de vie des bactéries d’origine marine, en dehors des conditions stériles habituelles. C’est une rencontre poétique et émotionnelle, dans l’intimité de ces « êtres de lumière » où l’homme est à la fois acteur et spectateur face à cette lumière qui interpelle sur notre manière de consommer et de consumer et la vie et la lumière.

  3. Porteurs de lumière(s) : Installation immersive de lumière vivante
  4. Performance théatralisée en hommage à Raphaël Dubois
  5. Nadia Merad Coliac and Maxime Bonnet joined the NOSE team

    Nadia Merad Coliac, plastic designer, joined the NOSE (Nasal Olfactory Stemness and Epigenesis) team, as an Associate researcher. At the crossroads of several disciplines, she develops an experimental work of art and science, in the field of bioluminescence. She is considering a therapeutic application in patients with autism spectrum disorders (ASD). Recently, Nadia published Lumière vivante - Théorie et pratique de la bioluminescence (Living light - theory and use of bioluminescence) - L’Harmattan eds.

Highligthed Publications

Team Publications