TCHOGHANDJIAN Aurelie
Primary tabs
Team
Platform
PETRA“TECH”
Localisation
Aix Marseille University Timone red wing second floor
Domaines de recherche
I am interesting in "pan-cellular" drugs which can target tumor cells and tumor-associated cells in mouse and human. To this end we are using an integrated in vivo approach in transgenic mice fluorescent for cell of interest and developing ex vivo human GB models.
Publications
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Deciphering the Action of Neuraminidase in Glioblastoma ModelsInternational Journal of Molecular Sciences2023
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Challenges in glioblastoma research: focus on the tumor microenvironmentTrends in Cancer2023
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Tau Regulates Glioblastoma Progression, 3D Cell Organization, Growth and Migration via the PI3K-AKT AxisCancers2021
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Practical Review on Preclinical Human 3D Glioblastoma Models: Advances and Challenges for Clinical TranslationCancers2020
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EB1-dependent long survival of glioblastoma-grafted mice with the oral tubulin-binder BAL101553 is associated with inhibition of tumor angiogenesisOncotarget2020
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Effects of VEGF blockade on the dynamics of the inflammatory landscape in glioblastoma-bearing miceJournal of Neuroinflammation2019
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Effects of VEGF blockade on the dynamics of the inflammatory landscape in glioblastoma-bearing miceJournal of Neuroinflammation2019
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Glycolipids Recognized by A2B5 Antibody Promote Proliferation, Migration, and Clonogenicity in Glioblastoma CellsCancers2019
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Inhibitor of Apoptosis Proteins Determine Glioblastoma Stem-Like Cells Fate in an Oxygen-Dependent MannerSTEM CELLS2019
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Proscillaridin A exerts anti-tumor effects through GSK3β activation and alteration of microtubule dynamics in glioblastomaCell Death and Disease2018
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The Novel Tubulin-Binding Checkpoint Activator BAL101553 Inhibits EB1-Dependent Migration and Invasion and Promotes Differentiation of Glioblastoma Stem-like CellsMolecular Cancer Therapeutics2016
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Phenotypic dynamics of microglial and monocyte-derived cells in glioblastoma-bearing miceScientific Reports2016
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Somatic gain-of-function HIF2A mutations in sporadic central nervous system hemangioblastomasJournal of Neuro-Oncology2016
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Molecular heterogeneity of glioblastomas: does location matter?Oncotarget2016
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Hypoxia-associated factor expression in low-grade and anaplastic gliomas: a marker of poor outcomeOncotarget2016
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Inhibitor of apoptosis protein expression in glioblastomas and their in vitro and in vivo targeting by SMAC mimetic GDC-0152Cell Death and Disease2016
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Identification of RIP1 as a critical mediator of Smac mimetic-mediated sensitization of glioblastoma cells for Drozitumab-induced apoptosisCell Death and Disease2015
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Recurrence of glioblastoma after radio-chemotherapy is associated with an angiogenic switch to the CXCL12-CXCR4 pathwayOncotarget2015
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Smac mimetic promotes glioblastoma cancer stem-like cell differentiation by activating NF-κBCell Death and Differentiation2014
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The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosis via mitochondrial-lysosomal cross-talkInternational Journal of Cancer2013
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Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cellsCell Death and Disease2013
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Evidence for new targets and synergistic effect of metronomic celecoxib/fluvastatin combination in pilocytic astrocytomaActa Neuropathologica Communications2013
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Cortical and subventricular zone glioblastoma-derived stem-like cells display different molecular profiles and differential in vitro and in vivo properties.Annals of Surgical Oncology2012
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Prognostic Impact of CD133 mRNA Expression in 48 Glioblastoma Patients Treated with Concomitant Radiochemotherapy: A Prospective Patient Cohort at a Single InstitutionAnnals of Surgical Oncology2011
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Alternative responses of primary tumor cells and glioblastoma cell lines to N,N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines: Cell death versus P53-independent senescenceInternational Journal of Oncology2010
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A2B5 cells from human glioblastoma have cancer stem cell propertiesBrain Pathology2010
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Pilocytic astrocytoma of the optic pathway: a tumour deriving from radial glia cells with a specific gene signatureBrain - A Journal of Neurology2009
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A2B5 cells from human glioblastoma have cancer stem cell propertiesBrain Pathology2009
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Relevance of combinatorial profiles of intermediate filaments and transcription factors for glioma histogenesisNeuropathology and Applied Neurobiology2007
