BARBIER Pascale
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Team
Platform
PINT
Localisation
faculté de pharmacie Marseille
Fonctions
Depuis Septembre 2013 Chargé de mission « référent APOGEE » pour la faculté de Pharmacie
Depuis 2007 : Responsable scientifique et techniques des études de caractérisations de protéines et d’interactions macromoléculaires par Ultracentrifugation analytique (Plateforme INteractome Timone (PINT).
2005-2009 Responsable de l’enseignement de la « Physique Appliquée aux Technologies Pharmaceutiques » au concours de première année de Pharmacie.
Enseignements
Enseignements de la biophysique au 1er année communes aux études de santé (PACES), 2-5ème année pharmacie, L2-3 sciences parcours biochimie pour 210 h eqTD
Spectroscopie UV visible, Fluorescence, Ultracentrifugation analytique, Détermination de constante d'affinité
Publications
http://api.archives-ouvertes.fr/search/?fq=authIdHal_i:18426&fl=title_s,en_title_s,docid,label_s,en_label_s,authIdHal_s,halId_s,structId_i,uri_s,keyword_s,en_keyword_s,authLastNameFirstName_s,journalTitle_s,abstract_s,en_abstract_s,producedDate_tdate,producedDateY_i,language_s&sort=publicationDate_s+desc
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2-Aminothiazole-Flavonoid Hybrid Derivatives Binding to Tau Protein and Responsible for Antitumor Activity in GlioblastomaInternational Journal of Molecular Sciences2023
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Identification of the three zinc-binding sites on tau proteinInternational Journal of Biological Macromolecules2022
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Myotoxin-3 from the Pacific Rattlesnake Crotalus oreganus oreganus Venom Is a New Microtubule-Targeting AgentMolecules2022
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Tau Regulates Glioblastoma Progression, 3D Cell Organization, Growth and Migration via the PI3K-AKT AxisCancers2021
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Insights into animal septins using recombinant human septin octamers with distinct SEPT9 isoformsJournal of Cell Science2021
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Allocolchicinoids bearing a Michael acceptor fragment for possible irreversible binding of tubulinRSC Medicinal Chemistry2020
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Discovery of dihydrofuranoallocolchicinoids - Highly potent antimitotic agents with low acute toxicityEuropean Journal of Medicinal Chemistry2020
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Role of Tau as a Microtubule-Associated Protein: Structural and Functional AspectsFrontiers in Aging Neuroscience2019
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Tau regulates the microtubule-dependent migration of glioblastoma cells via the Rho-ROCK signaling pathwayJournal of Cell Science2019
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Two Tau binding sites on tubulin revealed by thiol-disulfide exchangesScientific Reports2018
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Unraveling the Self-Assembly of the Pseudomonas aeruginosa XcpQ Secretin Periplasmic Domain Provides New Molecular Insights into Type II Secretion System Secreton Architecture and DynamicsmBio2017
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Self-assembly of XcpQ secretin N domain into hexamer of dimers provides new molecular insights into architecture and dynamics of widespread outer membrane channels2017
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Interactions of long-chain homologues of colchicine with tubulinEuropean Journal of Medicinal Chemistry2017
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Tau Interaction with Tubulin and Microtubules: From Purified Proteins to Cells2017
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Tau antagonizes end-binding protein tracking at microtubule ends through a phosphorylation- dependent mechanismMolecular Biology of the Cell2016
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Direct evidence for the interaction of stathmin along the length and the plus end of microtubules in cellsFASEB Journal2016
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Insights into the coiled-coil organization of the Hendra virus phosphoprotein from combined biochemical and SAXS studiesVirology2015
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Hsp90 Oligomerization Process: How Can p23 Drive the Chaperone Machineries?Biochimica et Biophysica Acta Proteins and Proteomics2015
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Hsp90 Oligomers Interacting with the Aha1 Cochaperone: An Outlook for the Hsp90 Chaperone MachineriesAnalytical Chemistry2015
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Synthesis and Biological Evaluation of FuranoallocolchicinoidsJournal of Medicinal Chemistry2014
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Mechanism of Tau-promoted microtubule assembly as probed by NMR spectroscopy.Journal of the American Chemical Society2014
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The Indolylcoumarin Coufin Exhibits Potent Activity Against Renal Carcinoma Cells without Affecting Hematopoietic System.Current Medicinal Chemistry Anticancer Agents2014
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Deciphering the molecular mechanisms of anti-tubulin plant derived drugsPhytochemistry Reviews2014
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Quantitative Analysis of Tau-Microtubule Interaction Using FRETInternational Journal of Molecular Sciences2014
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Molecular mechanisms of Tau binding to microtubules and its role in microtubule dynamics in live cells.Journal of Cell Science2013
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Microtubule-Associated Proteins and Tubulin Interaction by Isothermal Titration Calorimetry2013
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Synthesis and complete assignment of the 1H and 13C NMR signals of new acetamido and aminoflavonoid derivativesMagnetic Resonance in Chemistry2010
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Biochemical and biophysical characterization of the Mg2+-induced 90-kDa heat shock protein oligomers.Journal of Biological Chemistry2010
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Microtubule and MAPs: thermodynamics of complex formation by AUC, ITC, fluorescence, and NMR.Methods in Cell Biology2010
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Alzheimer disease specific phosphoepitopes of Tau interfere with assembly of tubulin but not binding to microtubules.FASEB Journal2009
