Team 2: Olivier Coulon
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The Institute of NeuroPhysiopathology (INP) is a training and research centre of excellence that combines basic and translational research to study neural cell organisation, function and interaction, the molecular and cellular bases of major brain diseases, and to develop innovative cellular and molecular therapeutic strategies.
Teams
NeuroTimone Facility (PFNT)
The PFNT Facility is a coherent set of exploration tools in neurobiology allowing research at the molecular, cellular and integrated levels.
News
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New publication in BioMedInformatics from Team 10 -
Another award for Emmanuel Snacel-FazyEmmanuel Snacel-Fazy, a 2nd year doctoral student in the GlioME team, won the best poster award at yesterday's "Conference Annuelle de L'institut Cancer et Immunologie (ICI)", Thursday 31 March 2022.
His work on the "Remodelling of the glioblastoma immune landscape by smac mimetic GDC-0152" has been appreciated and rewarded. Once again, congratulations!
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Two New articles from GlioME teamDr Romain Appay, pathologist at the Timone Hospital and PhD student in the GioME team, has published a new research paper entitled "Rosette-forming glioneuronal tumours are midline, FGFR1- mutated tumours" in the Neuropathology and Applied Neurobiology journal.
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New article from NPD Team 1 published in the Journal of NeuroinflammationThe latest article for NPD team 1 has been published this month into the Journal of Neuroinflammation.
Membrane-type matrix metalloproteinase 5 (MT5-MMP) deficiency in the 5xFAD mouse model of Alzheimer's disease reduces brain neuroinflammation along with amyloidosis, and prevents deficits in synaptic activity and cognition in prodromal stages of the disease. In addition, MT5-MMP deficiency prevents interleukin-1 beta (IL-1β)-mediated inflammation in the peripheral nervous system.
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Emmanuel Nivet on Neuro'binar - March 22nd 1pmDon't miss the next Neuro'binar of NeuroMarseille with Emmanuel Nivet (Team 6) !
Next Tuesday, on March 22nd, 2022, at 1 pm online, discover Dr Emmanuel Nivet's work in the 13th edition of Neuro'binar:
🔘 Emmanuel Nivet (INP) will present his research topic entitled: "Human induced pluripotent stem cells to study the role of astrocytes in Alzheimer’s disease"
🔘 Hannah Ihme (INT) and Martha Montse Rangel-Sosa (IBDM) - Ph.D. students - will present each other's Ph.D. projects in 5 min.
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A new publication is available on "Dual Photothermal and Chemotherapeutic Therapy"If you want to know more about the treatment of glioblastoma with Gold Nanorods, click on the title "Well-Defined Polyethylene Glycol Microscale Hydrogel Blocks Containing Gold Nanorods for Dual Photothermal and Chemotherapeutic Therapy" , a publication co-authored by Chiara Bastiancich, post-doc in the GlioME team.
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Congratulations to Dominika Pilat who is now a doctor in Neuroscience!To nicely end 2021 year, Dominika Pilat, student in Neural Plasticity and Degeneration Team (Team 1), successfully defended her thesis on the 16th of December. She gave a very clear, precise and comprehensive presentation highlighting the pivotal role of MT5-MMP in the neuroinflammation in an Alzheimer’s Disease model. The jury was unanimous to underline the great work Dominika accomplished during the four years she has spent at the INP leading to the publication of an article into the Journal of Neuroinflammation in which she is first author.
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Best presentation award for Emmanuel Snacel-FazyParticipating in the virtual conference "Tumor Microenvironment Heterogeneity in Cancer Progression: Challenge or Opportunity", Emmanuel Snacel-Fazy, a 2nd year PhD student in the GlioME team won the prize for the best presentation on the "Remodeling of the glioblstoma immune landscape by smac mimetic GDC-0152".
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INP in numbers
- 126 members
- 44 researchers
- 48 research assistants
- 12 post-docs
- 11 PhD
Evaluation de l'INP
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Team 8: Serge VAN DE PAVERT
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Team 1: Pedro Belio Mairal
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INP & Vect-Horus running against Alzheimer's disease
On december 10th 2022, PINT INP and Vect-Horus members met in the Hippodrome Borély for the "Course des Lumières" organized by Foundation Recherche Alzheimer. It was freezing but together with 600 or something others, they walked 5 km or ran 8 km, to light up the night against Alzheimer's disease and for all patients, carrying a luminous object. See a few pictures below
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Team 10 : New publication in Cancers
Simple Summary
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New website for the PETRA platform
The Cancéropole PACA has created a web page for the PETRA platform with all the necessary information and the contact form: PETRA web page.
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Two new publications for GlioME Team
In collaboration with other teams, the glioME team participated in two new scientific publications:
"Deciphering the heterogeneity of the Lyve1+ perivascular macrophages in the mouse brain": https://www.nature.com/articles/s41467-022-35166-9
"Challenges in glioblastoma research: focus on the tumor microenvironment": https://pubmed.ncbi.nlm.nih.gov/36400694/
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Welcome to Mensah, a new Master 2 student in team 10 !
Our team is pleased to welcome Mensah Loko for a 6 months Master internship (from November 2022) in Integrative Biology and Physiology: Integrative approach to the functions of life: from gene to pathology. The subject of his internship is the role of Adrenomedullin expressed by glioblastoma-associated endothelial cells in promoting a stable and functional angiogenesis.
English
3 first author papers for team 9 three PhD students
We are happy to celebrate the release of 3 first author papers on Myotoxin-3 from a snake venom as a new microtubule targeting agent, on the mechanism of action of Zinc induced aggregation of tau, and a review article on tau as a therapeutic target for cancer, for team 9 three PhD students : Cecilia, Dahbia and Rayane, this month :
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