JULLIEN Nicolas
Onglets principaux
Team
Localisation
2e étage - Aile verte
Fonctions
Au sein de l'équipe Neurocyto et en collaboration avec les différentes équipes de l'INP :
- Développement d'outils moléculaires : plasmides d'expression ou de 'silencing', édition génique,...
- Production et validation de constructions lentivirales et AAV
- Développement d'applications (bases de données et applications scientifiques)
Concepteur et développeur de :
AmplifX : Manage, test and design primers for PCR
Initiateur et développeur principal de FAB•LEUX (LiCoRNE, ...)
Publications
http://api.archives-ouvertes.fr/search/?fq=authIdHal_i:18899&fl=title_s,en_title_s,docid,label_s,en_label_s,authIdHal_s,halId_s,structId_i,uri_s,keyword_s,en_keyword_s,authLastNameFirstName_s,journalTitle_s,abstract_s,en_abstract_s,producedDate_tdate,producedDateY_i,language_s&sort=publicationDate_s+desc
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The actin-spectrin submembrane scaffold restricts endocytosis along proximal axonsScience2024
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Mutations in specific domains of MT5-MMP prevent the accumulation of toxic APP metabolites and serve as templates for peptide-based therapeutics in human in vitro models of Alzheimer's disease2024
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Presynapses contain distinct actin nanostructuresJournal of Cell Biology2023
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Deficient anterior pituitary with common variable immune deficiency (DAVID syndrome): a new case and literature reportsJournal of Neuroendocrinology2023
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APOE4 primes inflammation in human astrocytes through the downregulation of a newly discovered target candidatevv2021
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Human iPSCs-derived astrocytes reveal APOE as a critical modulator of inflammation that could underlie Alzheimer’s disease pathogenesis2021
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Clinical lessons learned in constitutional hypopituitarism from two decades of experience in a large international cohortClinical Endocrinology2021
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MT5-MMP controls APP and β-CTF/C99 metabolism through proteolytic-dependent and -independent mechanisms relevant for Alzheimer’s disease2020
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Impaired expression of the COSMOC/MOCOS gene unit in ASD patient stem cellsMolecular Psychiatry2020
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Heterozygous LHX3 mutations may lead to a mild phenotype of combined pituitary hormone deficiencyEuropean Journal of Human Genetics2019
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Lessons from monogenic causes of growth hormone deficiencyAnnales d'Endocrinologie = Annals of Endocrinology2017
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MECHANISMS IN ENDOCRINOLOGY: An update in the genetic aetiologies of combined pituitary hormone deficiencyEuropean Journal of Endocrinology2016
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GPR101 Mutations are not a Frequent Cause of Congenital Isolated Growth Hormone DeficiencyHormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme2016
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Identifying the Deleterious Effect of Rare LHX4 Allelic Variants, a Challenging IssuePLoS ONE2015
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Dose-Dependent Dual Role of PIT-1 (POU1F1) in Somatolactotroph Cell Proliferation and ApoptosisPLoS ONE2015
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Conditional genome engineering in Toxoplasma gondii uncovers alternative invasion mechanismsNature Methods2013
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Research Resource: A Genome-Wide Study Identifies Potential New Target Genes for POU1F1Molecular Endocrinology -Baltimore-2012
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Deficit in Anterior Pituitary Function and Variable Immune Deficiency (DAVID) in Children Presenting with Adrenocorticotropin Deficiency and Severe InfectionsJournal of Clinical Endocrinology and Metabolism2012
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LUEGO: a cost and time saving gel shift procedure.Biotechniques2011
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[Genetic aspects of growth hormone deficiency].Archives de Pédiatrie2011
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Use of ERT2-iCre-ERT2 for conditional transgenesisGenesis - The Journal of Genetics and Development2008
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Conditional Transgenesis Using Dimerizable Cre (DiCre)PLoS ONE2007
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Generation of immortalized human chromaffin cell lines for clinical applications.IRPC Recent avances and Research Updates2007
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Regulation of Cre recombinase by ligand-induced complementation of inactive fragmentsNucleic Acids Research2003
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SARS, ARSS, AND A,T-RICH REGIONS EVIDENCED BY RESTRICTION MAPPING ON AN 835-KB DNA FRAGMENT FROM DROSOPHILAExperimental Cell Research1995
