The Institute of NeuroPhysiopathology (INP) is a training and research centre of excellence that combines basic and translational research to study neural cell organisation, function and interaction, the molecular and cellular bases of major brain diseases, and to develop innovative cellular and molecular therapeutic strategies.
The PFNT Facility is a coherent set of exploration tools in neurobiology allowing research at the molecular, cellular and integrated levels.
In collaboration with other teams, the glioME team participated in two new scientific publications:
"Deciphering the heterogeneity of the Lyve1+ perivascular macrophages in the mouse brain": https://www.nature.com/articles/s41467-022-35166-9
"Challenges in glioblastoma research: focus on the tumor microenvironment": https://pubmed.ncbi.nlm.nih.gov/36400694/
Our team is pleased to welcome Mensah Loko for a 6 months Master internship (from November 2022) in Integrative Biology and Physiology: Integrative approach to the functions of life: from gene to pathology. The subject of his internship is the role of Adrenomedullin expressed by glioblastoma-associated endothelial cells in promoting a stable and functional angiogenesis.
We are happy to celebrate the release of 3 first author papers on Myotoxin-3 from a snake venom as a new microtubule targeting agent, on the mechanism of action of Zinc induced aggregation of tau, and a review article on tau as a therapeutic target for cancer, for team 9 three PhD students : Cecilia, Dahbia and Rayane, this month :
Clara Camilla, PhD student, Biology-Health - Oncology speciality, is starting her thesis on the theme: "Evaluation of Longitudinal Genomic Alterations in Diffuse Low Grade Gliomas in Adults".
Emeline Tabouret and Aurélie Tchoghandjian, in collaboration with Thierry Virolle's team at the l'Institut de Biologie Valrose in Nice, are among the two winners to have obtained "Action structurante" funding from the Cancéropôle PACA.
This funding aims to structure the neuro-oncology at the preclinical and translational level in the region (between Marseille and Nice) and will be used to create the PETRA (PrEclinical and TRAnslational Research) platform on these two sites.
Chiara Bastiancich published the last article of her first postdoc on GRAVITY project 🎉
The challenging goal was: delivering to the brain metallic nanoparticles via focused ultrasound-mediated blood-brain barrier (BBB) permeabilization, to heat them using lasers for glioblastoma photothermal therapy! In this paper she shows one of the steps to reach this daunting task.
Géraldine Ferracci (Study Engineer on the PINT platform) participated in the publication entitled "Molecular landscape of BoNT/B bound to a membrane inserted synaptotagmin/ganglioside complex" which appeared on August 25, 2022 in Cellular and Molecular Life Sciences.
Abstract :
Après une période transitoire où il est resté sur le site de la faculté Nord, le spectromètre de masse de l'INP (Thermo Scientific Q-exactive) est arrivé sur le site Timone cet été. Maya Belghazi ayant quitté l'INP pour rejoindre l'IMM, Claude Villard est dorénavant votre seul interlocuteur pour les projets en lien avec cet appareil.
Teams 8 and 9, along with the PINT and PETRA Network platforms, represented the lab at the Canceropôle Provence-Alpes-Côte d'Azur annual seminar. Another opportunity to highlight the work of our PhDstudents and researchers.
Rayane Hedna, Victoria Hein and Emmanuel Snacel-Fazy took up the challenge of the "teasing poster" session.
The GlioME team and the PETRA platform welcomed two BUT students, Ludivine Rouillon and Emilie Louat, for their end-of-year internship.
Their internship ended with a presentation of their work as posters entitled: "Développement d'un modèle pré-clinique 3D de tumoroïdes dérivé de tumeurs du SNC pour l'étude de molécules thérapeutiques" and "Analyse de l'expression de la protéine AP après traitement au témozolomide ou radiothérapie dans le glioblastome".
Join us on Tuesday 27 June 2023 from 1pm to 2pm for the 6th episode of the Canceropôle's "Seminar Series"!
Chiara will talk about her work on "A multidisciplinay journey of successes & pitfalls towards the development of tailored local treatments for glioblastoma"
==> ZOOM link
Assistée par Guillaume Thoraval, souffleur de l’université Paris cité, Nadia a elle-même créé des pièces en verre. Elle a été accueillie par le Fab-Lab de Paris Sorbonne, au labo de biologie pour la mise en culture et l’entretien des bactéries. L’œuvre présentée les 23 et 24 mai a reçu un franc succès et la qualité, ainsi que la démarche scientifique et artistique ont impressionnés les professionnels du milieu de l’art et les membres de l’institut de France, à laquelle est affiliée la fondation Laccolade.
Une exposition collective est prévue pour l’année prochaine.
Nathalie et Aurélie ont eu le plaisir d'accueillir dans l'équipe Lucas Gola, élève de première du Lycée Notre Dame de France dans le cadre du dispositif "Apprentis Chercheurs" porté par l'association "Arbre des connaissances".
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