Saccharomyces boulardii CNCM I-745 Restores intestinal Barrier Integrity by Regulation of E-cadherin Recycling

authors

• Terciolo Chloé
• Dobric Aurélie
• Ouaissi Mehdi
• Siret Carole
• Breuzard Gilles
• Silvy Françoise
• Marchiori Bastien
• Germain Sébastien
• Bonier Renaté
• Hama Adel
• Owens Róisín
• Lombardo Dominique
• Rigot Veronique
• André Frédéric

keywords

• Adherens junction
• Inflammatory bowel disease
• Intestinal permeability

abstract

Alteration in intestinal permeability is the main factor underlying the pathogenesis of many diseases affecting the gut, such as inflammatory bowel disease [IBD]. Characterization of molecules targeting the restoration of intestinal barrier integrity is therefore vital for the development of alternative therapies. The yeast Saccharomyces boulardii CNCM I-745 [Sb], used to prevent and treat antibiotic-associated infectious and functional diarrhea, may have a beneficial effect in the treatment of IBD.

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