Saccharomyces boulardii CNCM I-745 Restores intestinal Barrier Integrity by Regulation of E-cadherin Recycling


  • Terciolo Chloé
  • Dobric Aurélie
  • Ouaissi Mehdi
  • Siret Carole
  • Breuzard Gilles
  • Silvy Françoise
  • Marchiori Bastien
  • Germain Sébastien
  • Bonier Renaté
  • Hama Adel
  • Owens Róisín
  • Lombardo Dominique
  • Rigot Veronique
  • André Frédéric


  • Adherens junction
  • Inflammatory bowel disease
  • Intestinal permeability


Alteration in intestinal permeability is the main factor underlying the pathogenesis of many diseases affecting the gut, such as inflammatory bowel disease [IBD]. Characterization of molecules targeting the restoration of intestinal barrier integrity is therefore vital for the development of alternative therapies. The yeast Saccharomyces boulardii CNCM I-745 [Sb], used to prevent and treat antibiotic-associated infectious and functional diarrhea, may have a beneficial effect in the treatment of IBD.

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