RIVERA Santiago
Onglets principaux
Publications
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Mutations in specific domains of MT5-MMP prevent the accumulation of toxic APP metabolites and serve as templates for peptide-based therapeutics in human in vitro models of Alzheimer's disease2024
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Suppression of MT5-MMP reveals early modulation of Alzheimer’s pathogenic events in primary neuronal cultures of 5xFAD mice2024
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MT5-MMP promotes neuroinflammation, neuronal excitability and Aβ production in primary neuron/astrocyte cultures from the 5xFAD mouse model of Alzheimer’s diseaseJournal of Neuroinflammation2022
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The Alzheimer’s disease risk factor APOE4 drives pro-inflammation in human astrocytes via HDAC-dependent repression of TAGLN32022
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The C-terminal of MT5-MMP regulates C99 processing and Aβ levels in a cell model of Alzheimer's disease2022
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The Helico Maze Detects Early Impairment of Reference Memory at Three Months of Age in the 5XFAD Mouse Model of Alzheimer’s DiseaseJournal of Alzheimer's Disease2022
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APOE4 primes inflammation in human astrocytes through the downregulation of a newly discovered target candidatevv2021
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The Helico Maze Detects Early Impairment of Reference Memory at Three Months of Age in the 5XFAD Mouse Model of Alzheimer’s DiseaseJournal of Alzheimer's Disease2022
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APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activationCell Reports2022
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APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activationCell Reports2022
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MT5-MMP promotes neuroinflammation, neuronal excitability and Aβ production in primary neuron/astrocyte cultures from the 5xFAD mouse model of Alzheimer's diseaseJournal of Neuroinflammation2022
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The Alzheimer’s disease risk factor APOE4 drives pro-inflammation in human astrocytes via HDAC-dependent repression of TAGLN32021
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MT5-MMP is a modulator of inflammation: a study in murine and human neural cells related to Alzheimer’s disease2021
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MT5‐MMP controls APP and β‐CTF/C99 metabolism through proteolytic‐dependent and ‐independent mechanisms relevant for Alzheimer's diseaseFASEB Journal2021
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Human iPSCs-derived astrocytes reveal APOE as a critical modulator of inflammation that could underlie Alzheimer’s disease pathogenesis2021
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MT5-MMP at the crossroads of neuroinflammation and amyloidogenesis: study in murine and human neural cells2021
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Deficiency in MT5-MMP Supports Branching of Human iPSCs-Derived Neurons and Reduces Expression of GLAST/S100 in iPSCs-Derived AstrocytesCells2021
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MT5-MMP controls APP and β-CTF/C99 metabolism through proteolytic-dependent and -independent mechanisms relevant for Alzheimer’s disease2020
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Matrix metalloproteinases as new targets in Alzheimer's disease: Opportunities and ChallengesJournal of Medicinal Chemistry2020
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Donecopride, a Swiss army knife with potential interest against Alzheimer's diseaseBritish Journal of Pharmacology2020
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Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMPFrontiers in Aging Neuroscience2019
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Metalloproteinases in nervous system function and pathology: introductionCellular and Molecular Life Sciences2019
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Metalloproteinases and their tissue inhibitors in Alzheimer’s disease and other neurodegenerative disordersCellular and Molecular Life Sciences2019
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Long-Term Pantethine Treatment Counteracts Pathologic Gene Dysregulation and Decreases Alzheimer’s Disease Pathogenesis in a Transgenic Mouse ModelNeurotherapeutics2019
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Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP traffickingFASEB Journal2019
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Chronic treatments with a 5-HT4 receptor agonist decrease amyloid pathology in the entorhinal cortex and learning and memory deficits in the 5xFAD mouse model of Alzheimer's diseaseNeuropharmacology2017
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Microbiote intestinal et maladie d’Alzheimer : une piste stratégique pour des biomarqueurs innovants ?2017
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MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitroFrontiers in Molecular Neuroscience2017
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Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer's disease: Alleviation by pantethinePLoS ONE2017
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Impact du microbiote intestinal dans un modèle murin de maladie d’Alzheimer.2016
