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Titre: Step-by-step acquisition of synapse identity during mammalian brain development
The mature brain results from the formation of precise networks between functionally and morphologically distinct types of neurons. A given neuron forms synapses with a limited number of partners and on precise subcellular localizations. Understanding what controls this specificity is mandatory not only to understand brain functions but also the aetiology of synaptopathies such as autism spectrum disorders or schizophrenia. Neuronal activity-dependent mechanisms sculpt neuronal connectivity and control the plasticity of neuronal networks. In addition, genetic mechanisms define the identity of each type of synapse. Our team uses molecular and genetic approaches in the mouse to dissect the interplay between these regulatory mechanisms during postnatal development in a neuron- and synapse- specific manner. We focus on the olivocerebellar network, a network involved in motor control and in cognitive processes.
Recent relevant bibliography:
Paul MA*, Sigoillot SM*, Marti L, Delagrange M, Mailly P, Selimi F. Stepwise molecular specification of excitatory synapse diversity on a target neuron. bioRxiv 2023.01.03.521946.
Veleanu M*, et al. Transient molecular changes and lasting synaptic effects in the cerebellum of the neonatal phencyclidine mouse model of schizophrenia. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2122544119. doi: 10.1073/pnas.2122544119.
González-Calvo I*, et al. Sushi domain-containing protein 4 controls synaptic plasticity and motor learning. Elife. 2021 Mar 4;10:e65712. doi: 10.7554/eLife.65712
plus d'infos : https://www.college-de-france.fr/fr/personne/fekrije-selimi
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