Date de l'évènement:
Dimanche, 15 Septembre, 2024
A new article from the GlioME Team has just been published in Cell Death and Disease: SMAC mimetic drives microglia phenotype and glioblastoma immune microenvironment.
By using original human derived models, transgenic mouse, cutting-edge imaging technics and single-cell RNA sequencing, the GlioME team showed the impact of SMAC mimetics in modulating the immune landscape of glioblastoma. This work identifies IAP (Inhibitor of Apoptosis Proteins) as targets of choice for a potential mechanism-based therapeutic strategy and SMAC mimetic as a promising molecule for this application.
Special congratulations to Emmanuel Snacel-Fazy who dedicated his doctoral thesis to this work supervised by Aurélie Tchoghandjian.
