Epigenetics in NG2 glia cells

authors

• Moyon Sarah
• Liang Jialiang
• Casaccia Patrizia

keywords

• NG2 cell Oligodendrocyte progenitor cell Epigenetics Proliferation Differentiation

abstract

The interplay of transcription and epigenetic marks is essential for oligodendrocyte progenitor cell (OPC) proliferation and differentiation during development. Here, we review the recent advances in this field and highlight mechanisms of transcriptional repression and activation involved in OPC proliferation, differentiation and plasticity. We also describe how dysregulation of these epigenetic events may affect demyelinating disorders, and consider potential ways to manipulate NG2 cell behavior through modulation of the epigenome.

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