GlioME: Gliomagenesis and MicroEnvironment

A new article from the GlioME Team has just been published in Cell Death and Disease: SMAC mimetic drives microglia phenotype and glioblastoma immune microenvironment.

Because generation of patient avatar for preclinical therapeutic development is critically needed in neuro-oncology, the GlioME team in collaboration with the PETRA"TECH" platform developed an easy method to generate tumoroids from primary and metastatic brain tumors, including a dedicated 3D spatial analysis workflow for drug development.

Three presentations at the ESMO Congress 2024 (Barcelona, 13–17 September) reported on therapies designed to stimulate or boost the body’s antitumour immune response in the management of aggressive, high-grade gliomas, which typically carry a poor prognosis.

Emeline Tabouret from GlioME Team discussed these data during the proffered paper session – CNS tumours reported here.

Comme chaque année les équipes 8, 9 et 10 de l’INP ont participé au Séminaire Annuel du Canceropôle qui se tenait au Palais des Congrès de Saint-Raphaël les 4 et 5 juillet 2024.

On 4 April, Nora Essakhi, Roberta Stacchini and Alexandre Bertucci, PhD students in the GlioME team, presented their poster at the 5th Scientific Annual Conference - Institut Cancer et Immunologie (ICI) on the theme of "CAR T cells, advances in cellular engineering and future challenges in cancer therapy".

The review "GD3 ganglioside is a promising therapeutic target for glioma patients" is now published in Neuro-oncology Advances.  

Congratulations to Victoria Hein, Nathalie Baeza-Kallee, Alexandre Bertucci, Carole Colin, Aurélie Tchoghandjian, Dominique Figarella-Branger, Emeline Tabouret for this work. 

Chiara Bastiancich (GlioME) and Maud Gratuze (SynapTau) participated to the CNRS welcome day in Paris. 

It was a great opportunity for them to meet the 770 other new recruits of the CNRS in 2023 and to get to know their new scientific ally better!

L'AP-HM (Assistance Publique - Hôpitaux de Marseille) a fait le portrait d'Emeline Tabouret pour la 𝙅𝒐𝙪𝒓𝙣𝒆́𝙚 𝙞𝒏𝙩𝒆𝙧𝒏𝙖𝒕𝙞𝒐𝙣𝒂𝙡𝒆 𝒅𝙚𝒔 𝒇𝙚𝒎𝙢𝒆𝙨 𝙙𝒆 𝒔𝙘𝒊𝙚𝒏𝙘𝒆.

Aurélie Soubéran and Nathalie Baeza-Kallee represented the GlioME team at the symposium on cortical and spinal organoid at the Institut Jacques Monod in Paris. 

The work presented in this poster arose from a collaboration with team 6 (Louise Greetham and Emmanuel Nivet) on the development of an assemboid model (tumor + brain organoid). 

The RENOCLIP national meeting was held at the Institut de Cerveau et de la Moelle Epinière in Paris, with the aim of providing an update on research projects and patient management. 

Alexandre Bertucci, medical intern and PhD student in the GlioME team, presented the histomolecular profile of young oligodendrogliomas included in the pola network.