CDA as a predictive marker for life-threatening toxicities in patients with AML treated with cytarabine

authors

• Fanciullino Raphaelle
• Farnault Laure
• Donnette Mélanie
• Imbs Diane-Charlotte
• Roche Catherine
• Venton Geoffroy
• Berda-Haddad Yael
• Ivanov Vadim
• Ciccolini Joseph
• Ouafik L’houcine
• Lacarelle Bruno
• Costello Régis

abstract

Key Points Ara-C is the mainstay of treatment for patients with AML, and life-threatening toxicities are common. We demonstrated that cytidine deaminase downregulation predicts severe/lethal toxicities with cytarabine.

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