MT5-MMP, just a new APP processing proteinase in Alzheimer's disease?
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authors
keywords
- Matrix metalloproteinases
- Neurodegenerative disease
- Trafficking
- Neuroinflammation
- IL-1β
- Amyloidogenesis
- Amyloid precursor protein
abstract
We have recently identified in a transgenic mouse model of Alzheimer's ă disease (AD) membrane-type 5-MMP (MT5-MMP) as a new player in ă Alzheimer's pathogenesis, which displays pro-amyloidogenic features and ă proteolytic processing of amyloid precursor protein (APP). Another group ă has reported that MT5-MMP processing of APP may release a novel ă neurotoxic APP fragment. Although MT5-MMP-mediated APP processing ă appears to be a key pathogenic step, we hypothesize that MT5-MMP may ă also contribute to AD pathogenesis through complementary mechanisms that ă involve the activation of pro-inflammatory pathways and/or APP ă trafficking.
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