COLIN Carole
Onglets principaux
Team
Platform
PETRA“TECH”
Localisation
Faculté des Sciences médicales et paramédicales, 2ème étage aile rouge
Fonctions
Ingénieur de Recherche AMU depuis décembre 2007.
Mes missions sont dédiées:
- à 40% à la recherche fondamentale au sein de l’équipe de recherche GlioME (analyse statistique des données expérimentales: logiciels SPSS statistics et XLSTAT; exploitation de bases de données: TCGA, GEO, Rembrandt, Gravendeel, GlioVis)
- et à 60% à une recherche plus translationnelle impliquant plusieurs réseaux locaux (interface entre l'équipe GlioME, les services cliniques partenaires, l'association de patients pour la recherche sur les tumeurs cérébrales ARTC-Sud), nationaux (RENOCLIP-LOC: REseau de NeuroOncologie CLInico-Pathologique) et européens (SIOP-LGG sur les gliomes de bas grade de l'enfant et de l'adulte jeune).
Domaines de recherche
3 axes d'étude principaux:
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Caractérisation histo-moléculaire des tumeurs gliales et glioneuronales de l'enfant et de l'adulte.
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Identification et détection de biomarqueurs diagnostiques et pronostiques dans les gliomes humains.
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Développement de nouvelles stratégies thérapeutiques ciblant les glycolipides reconnus par l’anticorps A2B5 (G-A2B5) dans le glioblastome.
Site web perso
www.linkedin.com/in/carole-colin-2527b8151
Publications
http://api.archives-ouvertes.fr/search/?fq=authIdHal_i:19785&fl=title_s,en_title_s,docid,label_s,en_label_s,authIdHal_s,halId_s,structId_i,uri_s,keyword_s,en_keyword_s,authLastNameFirstName_s,journalTitle_s,abstract_s,en_abstract_s,producedDate_tdate,producedDateY_i,language_s&sort=publicationDate_s+desc
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Deciphering the Action of Neuraminidase in Glioblastoma ModelsInternational Journal of Molecular Sciences2023
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Rosette‐forming glioneuronal tumours are midline, FGFR1 ‐mutated tumoursNeuropathology and Applied Neurobiology2022
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Low-grade epilepsy-associated neuroepithelial tumours with a prominent oligodendroglioma-like component: the diagnostic challengesNeuropathology and Applied Neurobiology2022
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The Implementation of DNA Methylation Profiling into a Multistep Diagnostic Process in Pediatric Neuropathology: A 2-Year Real-World Experience by the French Neuropathology NetworkCancers2021
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Diffuse leptomeningeal glioneuronal tumor: a double misnomer? A report of two casesActa Neuropathologica Communications2020
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Multiplexed Droplet Digital PCR Assays for the Simultaneous Screening of Major Genetic Alterations in Tumors of the Central Nervous SystemFrontiers in Oncology2020
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Ki-67 and MCM6 labelling index are correlated with overall survival in anaplastic oligodendroglioma, IDH1-mutant and 1p/19q codeleted: a multicenter study from the French POLA Network2019
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Glycolipids Recognized by A2B5 Antibody Promote Proliferation, Migration, and Clonogenicity in Glioblastoma CellsCancers2019
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CDKN2A homozygous deletion is a strong adverse prognosis factor in diffuse malignant IDH-mutant gliomasNeuro-Oncology2019
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Neuro-radiological characteristics of adult diffuse grade II and III insular gliomas classified according to WHO 2016Journal of Neuro-Oncology2019
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Inhibitor of Apoptosis Proteins Determine Glioblastoma Stem-Like Cells Fate in an Oxygen-Dependent MannerSTEM CELLS2019
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Grading of Meningeal Solitary Fibrous Tumors/Hemangiopericytomas: Prognostic Value of the Marseille Grading System in a Cohort of 132 Patients in correlation with molecular dataBrain Pathology2019
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Duplications of KIAA1549 and BRAF screening by Droplet Digital PCR from formalin-fixed paraffin-embedded DNA is an accurate alternative for KIAA1549-BRAF fusion detection in pilocytic astrocytomasModern Pathology2018
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IDH2 mutations are commonly associated with 1p/19q codeletion in diffuse adult gliomasNeuro-Oncology2018
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Somatostatin receptor 2A protein expression characterizes anaplastic oligodendrogliomas with favorable outcomeActa Neuropathologica Communications2018
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Mitotic index, microvascular proliferation, and necrosis define 3 pathological subgroups of prognostic relevance among 1p/19q co-deleted anaplastic oligodendrogliomas.Neuro-Oncology2016
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Integrated multi-omics analysis of oligodendroglial tumours identifies three subgroups of 1p/19q co-deleted gliomasNature Communications2016
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Inhibitor of apoptosis protein expression in glioblastomas and their in vitro and in vivo targeting by SMAC mimetic GDC-0152Cell Death and Disease2016
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Prognostic impact of the 2016 WHO classification of diffuse gliomas in the French POLA cohortActa Neuropathologica2016
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Droplet digital PCR is a powerful technique to demonstrate frequent FGFR1 duplication in dysembryoplastic neuroepithelial tumorsOncotarget2016
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TP53 codon 72 polymorphism may predict early tumour progression in paediatric pilocytic astrocytomaOncotarget2016
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Supratentorial clear cell ependymomas with branching capillaries demonstrate characteristic clinicopathological features and pathological activation of nuclear factor-kappaB signalingNeuro-Oncology2016
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Molecular heterogeneity of glioblastomas: does location matter?Oncotarget2016
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Prognostic Relevance of Histomolecular Classification of Diffuse Adult High-Grade Gliomas with NecrosisBrain Pathology2015
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Evidence for BRAF V600E and H3F3A K27M double mutations in paediatric glial and glioneuronal tumoursNeuropathology and Applied Neurobiology2015
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Tumor and Endothelial Cell Hybrids Participate in Glioblastoma VasculatureBioMed Research International2014
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Evidence for new targets and synergistic effect of metronomic celecoxib/fluvastatin combination in pilocytic astrocytomaActa Neuropathologica Communications2013
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Cortical and subventricular zone glioblastoma-derived stem-like cells display different molecular profiles and differential in vitro and in vivo properties.Annals of Surgical Oncology2012
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IDH mutation status impact on in vivo hypoxia biomarkers expression: new insights from a clinical, nuclear imaging and immunohistochemical study in 33 glioma patientsJournal of Neuro-Oncology2011
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Prognostic Impact of CD133 mRNA Expression in 48 Glioblastoma Patients Treated with Concomitant Radiochemotherapy: A Prospective Patient Cohort at a Single InstitutionAnnals of Surgical Oncology2011
