KHRESTCHATISKY Michel
Onglets principaux
Publications
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A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective and anti-inflammatory properties following status epilepticus in mice2024
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Mutations in specific domains of MT5-MMP prevent the accumulation of toxic APP metabolites and serve as templates for peptide-based therapeutics in human in vitro models of Alzheimer's disease2024
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LDLR-Mediated Targeting and Productive Uptake of siRNA-Peptide Ligand Conjugates In Vitro and In VivoPharmaceutics2024
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In the Rat Hippocampus, Pilocarpine-Induced Status Epilepticus Is Associated with Reactive Glia and Concomitant Increased Expression of CD31, PDGFRβ, and Collagen IV in Endothelial Cells and Pericytes of the Blood–Brain BarrierInternational Journal of Molecular Sciences2024
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Pilocarpine-Induced Status Epilepticus in the Rat Hippocampus is Associated with Reactive Glia and Concomitant Increased Expression of CD31, PDGFRβ and Collagen IV in Endothelial Cells and Pericytes of the Blood Brain Barrier2023
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Neurotensin and Neurotensin Receptors in Stress-related Disorders: Pathophysiology & Novel Drug TargetsCurrent Neuropharmacology2023
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LDLR-mediated targeting and productive uptake of siRNA-peptide ligand conjugates in vitro and in vivo2023
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High and low permeability of human pluripotent stem cell–derived blood–brain barrier models depend on epithelial or endothelial featuresFASEB Journal2023
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Neurotensin and Neurotensin Receptors in Stress-related Disorders: Pathophysiology & Novel Drug TargetsCurrent Neuropharmacology2023
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MT5-MMP promotes neuroinflammation, neuronal excitability and Aβ production in primary neuron/astrocyte cultures from the 5xFAD mouse model of Alzheimer’s diseaseJournal of Neuroinflammation2022
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LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinomaCommunications Biology2021
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LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma.Communications Biology2021
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Neurotensin receptor 2 is induced in astrocytes and brain endothelial cells in relation to neuroinflammation following pilocarpine‐induced seizures in ratsGlia2021
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MT5-MMP is a modulator of inflammation: a study in murine and human neural cells related to Alzheimer’s disease2021
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MT5‐MMP controls APP and β‐CTF/C99 metabolism through proteolytic‐dependent and ‐independent mechanisms relevant for Alzheimer's diseaseFASEB Journal2021
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The Helico Maze allows testing of early learning and subcategories of long-term memory in miceBehavioural Brain Research2021
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Human iPSCs-derived astrocytes reveal APOE as a critical modulator of inflammation that could underlie Alzheimer’s disease pathogenesis2021
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MT5-MMP at the crossroads of neuroinflammation and amyloidogenesis: study in murine and human neural cells2021
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The actin binding protein α-actinin-2 expression is associated with dendritic spine plasticity and migrating granule cells in the rat dentate gyrus following pilocarpine-induced seizuresExperimental Neurology2021
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Neurotensin receptor 2 is induced in astrocytes and brain endothelial cells in relation to status epilepticus and neuroinflammation following pilocarpine administration in rats2020
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MT5-MMP controls APP and β-CTF/C99 metabolism through proteolytic-dependent and -independent mechanisms relevant for Alzheimer’s disease2020
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High levels of serum soluble TWEAK are associated with neuroinflammation during multiple sclerosisJournal of Translational Medicine2019
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gH625-liposomes as tool for pituitary adenylate cyclase-activating polypeptide brain deliveryScientific Reports2019
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Target engagement and intracellular delivery of mono- and bivalent LDL receptor-binding peptide-cargo conjugates: Implications for the rational design of new targeted drug therapiesJournal of Controlled Release2019
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Metalloproteinases and their tissue inhibitors in Alzheimer’s disease and other neurodegenerative disordersCellular and Molecular Life Sciences2019
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Long-Term Pantethine Treatment Counteracts Pathologic Gene Dysregulation and Decreases Alzheimer’s Disease Pathogenesis in a Transgenic Mouse ModelNeurotherapeutics2019
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Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP traffickingFASEB Journal2019
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Isolation and characterization of olfactory ecto-mesenchymal stem cells from eight mammalian generaBMC Veterinary Research2018
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Correction to: Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017Fluids and Barriers of the CNS2018
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Grafts of olfactory stem cells restore breathing and motor functions after a rat spinal cord injuryJournal of Neurotrauma2018
