NeuroTimone Facility (PFNT)

The PFNT Facility is a coherent set of exploration tools in neurobiology allowing research at the molecular, cellular and integrated levels.

News

  1. The CNRS features Vect-Horus and the INP in the Innovation Letter of April

    In the CNRS Innovation Letter of April, there is an article entitled "Des molécules vectorisées pour cibler les maladies neurodégénératives" featuring the research collaboration agreement signed by Vect-Horus and Johnson & Johnson subsidiary Janssen Pharmaceuticals for treating neurodegenerative diseases.

  2. INP students presented their research work at the 14th International Conference on Alzheimer's and Parkinson's Diseases (ADPD)

    On the 26-31st March, the 14th International Conference on Alzheimer's and Parkinson's Diseases (ADPD) and related neurological disorders was held in Lisbon, Portugal. This year, almost the entire team 1 and team 6 went to this major event and our students: Laurie Arnaud, Laura García González and Dominika Pilat took the opportunity to present their work on a poster.

  3. New publication from the NeuroCyto team in Nature Communications: Perform advanced microscopy experiments thanks to NanoJ-Fluidics

    The LEGO Pumpy (or more officially NanoJ-Fluidics) paper is out in Nature Communications! A joint venture between the INP NeuroCyto team and the Henriques lab, this article (previously available as a preprint on bioRxiv) details how to build a fully open-source multi-channel syringe pumps with LEGO and Arduino.

  4. New preprint from the NeuroCyto team: tips and tricks for super-resolution microscopy

    We have a new preprint out! Want to do good super-resolution images? We have put together all our single molecule localization microscopy (SMLM) tips and tricks. This is a methods paper that describes our SMLM workflow, using benchmark samples such as microtubules and clathrin-coated pits. 

  5. Hotspots seen by STORM
    New publication from the NeuroCyto team in the Journal of Cell Biology: Slow axonal transport of actin via hotspots and trails

    Our latest work (previously on bioRxiv) is now published in the Journal of Cell Biology. We collaborated with the Roy lab (UW Madison, USA) and the Jung lab (Ohio University, USA) to reveal a new mechanism of slow axonal transport, based on our previous discovery of actin hotspots and trails

  6. Christophe at MiFoBio
    Christophe from the NeuroCyto team delivers plenary lecture at MiFoBio 2018

    Christophe was lucky to spend a whole week at the “Microscopie Fonctionnelle en Biologie” aka MiFoBio workshop. Lots of fun attending dozens of cutting-edge workshops, trying super-resolution microscopes, discussing, DJing (!), and presenting the latest work from the lab.

    More on Twitter: #MiFoBio2018

  7. The GlioME team has popularized a scientific article to make its research accessible to the general public.
  8. F. Devred presented PINT / INP work on a non-conventional use of nanoDSF at the ARBRE MOBIEU meeting

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INP in numbers

  • 126 members
  • 44 researchers
  • 48 research assistants
  • 12 post-docs
  • 11 PhD

 

The GlioME team published a new article in Oncotarget journal: EB1-dependent long survival of glioblastoma-grafted mice with the oral tubulin-binder BAL101553 is associated with inhibition of tumor angiogenesis.

Our study shows that a treatment with the microtubule-destabilizing agent BAL101553 counteracts tumor angiogenesis by acting on glioblastoma stem-like cells, in an EB1-dependent manner. This work provides new insights into the therapeutic targeting of cancer stem-like cells.

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Aurélie Tchoghandjian, jeune chercheur dans l'équipe GlioME a brillament obtenu son Habilitation à Diriger les Recherches (HDR)

Aurélie Tchoghandjian a soutenu son Habilitation à Diriger les Recherches (HDR) devant un jury d'experts composé de cliniciens : Pr. Nicolas André, Pr. François Ducray, Pr. Dominique Figarella-Branger; et de chercheurs : Dr. Emmanuelle Huillard et Dr. Monique Dontenwill.

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New publication from Sylvie Carmona (Neuro-inflammation and Multiple Sclerosis team - INP team 5)

As part of her PhD, Sylvie Carmona investigated the beneficial effects of NV669, an aminosterol derived from squalamine on human pancreatic and hepatic cancer models. In vitro results exposed in this paper showed that NV669 inhibited the proliferation of cancer cells, induced cell cycle arrest and subsequent apoptosis. Moreover, NV669 inhibited PTP1B activity and impacted adhesion molecules expression. This suggests that NV669 by inhibiting PTP1B would affect cell contacts and would induce apoptosis.

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Deux nouveaux arrivants dans l'équipe GlioME

L'équipe 8 (GlioME) a le plaisir d'accueillir deux étudiants en Master 2, Anaïs Arathni étudiante en Master Biologie Santé et Emmanuel Snacel-Fazy étudiant en Master Neurosciences. Anaïs travaillera avec Aurélie Tchoghandjian sur la caractérisation des cellules immunitaires recrutées sur le site tumoral suite au traitement par mimétiques de Smac. Emmanuel travaillera avec Chiara Bastiancich sur le microenvironnement de la résection tumorale du glioblastome.

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