Neural Plasticity and Degeneration

Rafael Godoy, recipient of the prestigious Eiffel Excellence Scholarship, recently started a two-month internship in the Neural Plasticity and Degeneration team. Originally from João Pessoa, Brazil, he is currently pursuing a Master's degree in Neurosciences at the Aix-Marseille University.

During his internship, he will be working on the effects of MT5-MMP on neuroinflammation and intracellular trafficking.

Dans son édition du vendredi 31 mai 2024, La Provence mettait l'INP à l'honneur dans son dossier sur la maladie d'Alzheimer. Le Pr Mathieu Ceccaldi (Service de Neurologie et Neuropsychologie Adultes & équipe 9) était interrogé sur les nouveaux traitements, pendant que François Devred (équipe 9) et Santiago Rivera (équipe 1) étaient eux interrogés sur les travaux des "six équipes qui bossent à temps plein dans ce "gros" laboratoire français de recherche sur Alzheimer"

The last 2 weeks, several INP teams hosted M1 students for their APP (Apprentissage Par Projet). For many, it was a first experience in a research lab! Each APP is organized around a larger project (Alzheimer's Disease, Myelin, Functional imaging) and students rotate between different labs of NeuroMarseille.

Thanks to Laurence, Christine (Team 1), Theresa, Fanny (Team 7), Naz and Marine (Team 4) for mentoring all these students!

Congratulations to Chiara Bordier (SynapTau team) and Thaïs Lestra (Neural Plasticity and Degeneration team), who have been selected by the France Alzheimer's association for their "Parrainage Jeunes Chercheurs" initiative. The objective of this program is to support young researchers throughout their three-year thesis. We are proud of them!

Comme chaque année la Faculté de Pharmacie de Marseille met à l'honneur ses doctorants, chercheurs et enseignants-chercheurs lors de sa Journée de la Recherche qui avait lieu cette année le 12 octobre 2023;  Au cours de cette journée les enseignants chercheurs de la faculté Pascale Barbier, François Devred, Hervé Kovacic (équipe 9), et Alessandra Pagano (équipe 8) accompagnés de  Chiara Bastiancich, Aurélie Souberan (équipe 8) et Maud Gratuze (équipe 2') étaient présents po

As part of the 2023 edition of the Cercles des Savoirs program at the Roquebrussanne Open University, Dr. Santiago Rivera led a conference on Saturday September 23d entitled "Alzheimer's disease, fears and hopes".

The latest article for NPD team 1 has been published this month into the Journal of Neuroinflammation.

Membrane-type matrix metalloproteinase 5 (MT5-MMP) deficiency in the 5xFAD mouse model of Alzheimer's disease reduces brain neuroinflammation along with amyloidosis, and prevents deficits in synaptic activity and cognition in prodromal stages of the disease. In addition, MT5-MMP deficiency prevents interleukin-1 beta (IL-1β)-mediated inflammation in the peripheral nervous system.

To nicely end 2021 year, Dominika Pilat, student in Neural Plasticity and Degeneration Team (Team 1), successfully defended her thesis on the 16th of December. She gave a very clear, precise and comprehensive presentation highlighting the pivotal role of MT5-MMP in the neuroinflammation in an Alzheimer’s Disease model.

On February 22nd at 1 pm don't miss the next Neurobinar of NeuroMarseille !

Neural Plasticity and Degeneration team has recently welcomed Shweta SONAWANE.

Shweta is from Mumbai (India) she did her Ph.D. at the Biochemical sciences division of CSIR - National Chemical Laboratory in Pune (India).

Her doctoral research was largely focused on Tau pathology in Alzheimer’s disease studying in particular the effect of glycated and phosphorylated Tau on cytoskeleton integrity as well as aggregation propensity in order to find small molecules that could attenuate Tau aggregation and prevent its glycation.