Characteristics of Anaplastic Oligodendrogliomas Short-Term Survivors: A POLA Network Study

authors

• Garnier Louis
• Vidal Chrystelle
• Chinot Olivier
• Cohen-Jonathan Moyal Elisabeth
• Djelad Apolline
• Bronnimann Charlotte
• Bekaert Lien
• Taillandier Luc
• Frenel Jean-Sébastien
• Langlois Olivier
• Colin Philippe
• Menei Philippe
• Dhermain Frédéric
• Carpentier Catherine
• Gerazime Aurélie
• Curtit Elsa
• Figarella-Branger Dominique
• Dehais Caroline
• Ducray François

keywords

• Karnofsky Performance Status
• Age
• Anaplastic oligodendroglioma
• Chemotherapy
• Proliferation
• Radiotherapy
• Seizure
• Surgery

abstract

Background Anaplastic oligodendrogliomas IDH-mutant and 1p/19q codeleted (AO) occasionally have a poor outcome. Herein we aimed at analyzing their characteristics. Methods We retrospectively analyzed the characteristics of 44 AO patients with a cancer-specific survival <5 years (short-term survivors, STS) and compared them with those of 146 AO patients with a survival ≥5 years (classical survivors, CS) included in the POLA network. Results Compared to CS, STS were older (P = .0001), less frequently presented with isolated seizures (P < .0001), more frequently presented with cognitive dysfunction (P < .0001), had larger tumors (P = .= .003), a higher proliferative index (P = .= .0003), and a higher number of chromosomal arm abnormalities (P = .= .02). Regarding treatment, STS less frequently underwent a surgical resection than CS (P = .= .0001) and were more frequently treated with chemotherapy alone (P = .= .009) or with radiotherapy plus temozolomide (P = .= .05). Characteristics independently associated with STS in multivariate analysis were cognitive dysfunction, a number of mitosis > 8, and the absence of tumor resection. Based on cognitive dysfunction, type of surgery, and number of mitosis, patients could be classified into groups of standard (18%) and high (62%) risk of <5 year survival. Conclusion The present study suggests that although STS poor outcome appears to largely result from a more advanced disease at diagnosis, surgical resection may be particularly important in this population.

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