Cytoplasmic keratins couple with and maintain nuclear envelope integrity in colonic epithelial cells
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Cytoplasmic keratins couple with SUN2 and lamin A at the nuclear envelope and maintain plectin, LINC complex, lamin and lamin-associated protein levels in colonic epithelial cells. Loss of keratin 8 has no major impact on nuclear shape and size, but compromises nuclear envelope integrity basally and during shear stress.
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