Targeting Adrenomedullin in Oncology: A Feasible Strategy With Potential as Much More Than an Alternative Anti-Angiogenic Therapy
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authors
keywords
- Adrenomedullin
- Angiogenesis
- Cancer
- Metastasis
- AM 1 and AM 2
- RAMP1-3
abstract
tumor angiogenesis, metastasis and growth following treatment with AM-neutralizing antibodies, AM receptor antagonists, or AM receptor interference. Anti-AM therapy is a promising strategy to be explored in oncology, not only as an anti-angiogenic alternative in the context of acquired resistance to VEGF treatment, but also as a potential antimetastatic approach.
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