Clinical Management of Diffuse Low-Grade Gliomas

authors

• Lombardi Giuseppe
• Barresi Valeria
• Castellano Antonella
• Tabouret Emeline
• Pasqualetti Francesco
• Salvalaggio Alessandro
• Cerretti Giulia
• Caccese Mario
• Padovan Marta
• Zagonel Vittorina
• Ius Tamara

keywords

• Chemotherapy
• Diffuse low-grade gliomas
• Radiotherapy
• Surgery
• Targeted therapy

abstract

Diffuse low-grade gliomas (LGG) represent a heterogeneous group of primary brain tumors arising from supporting glial cells and usually affecting young adults. Advances in the knowledge of molecular profile of these tumors, including mutations in the isocitrate dehydrogenase genes, or 1p/19q codeletion, and in neuroradiological techniques have contributed to the diagnosis, prognostic stratification, and follow-up of these tumors. Optimal post-operative management of LGG is still controversial, though radiation therapy and chemotherapy remain the optimal treatments after surgical resection in selected patients. In this review, we report the most important and recent research on clinical and molecular features, new neuroradiological techniques, the different therapeutic modalities, and new opportunities for personalized targeted therapy and supportive care.

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