Medulloblastomas associated with an APC germline pathogenic variant share the good prognosis of CTNNB1-mutated medulloblastomas

authors

• Surun Aurore
• Varlet Pascale
• Brugières Laurence
• Lacour Brigitte
• Faure-Conter Cécile
• Leblond Pierre
• Bertozzi-Salomon Anne-Isabelle
• Berger Claire
• André Nicolas
• Sariban Eric
• Raimbault Sandra
• Prieur Fabienne
• Desseigne Françoise
• Zattara Hélène
• Guimbaud Rosine
• Polivka Marc
• Delisle Marie-Bernadette
• Vasiljevic Alexandre
• Maurage Claude-Alain
• Figarella‑branger Dominique
• Coulet Florence
• Guerrini-Rousseau Léa
• Alapetite Claire
• Dufour Christelle
• Colas Chrystelle
• Doz François
• Bourdeaut Franck

keywords

• APC
• Gardner syndrome
• WNT
• Familial adenomatosis polyposis
• Medulloblastoma

document type

abstract

Medulloblastomas may occur in a predisposition context, including familial adenomatosis polyposis. Medulloblastomas related to a germline pathogenic variant of adenomatous polyposis coli (APC) remain rare and poorly described. Their similarities with sporadic WNT medulloblastomas still require description.

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